Discharge of intrapulmonary chemoreceptors and its modulation by rapid FiCO2 changes in decerebrate ducks

Berger, Philip J.; Tallman, Richard D.; Kunz, A. L.

doi:10.1016/0034-5687(80)90109-7

Cited by 18 publications

(5 citation statements)

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“…However, it is known that CO2 is involved in the control of normal breathing in birds via central and systemic chemoreceptors and also directly by its effects on the neural discharge of intrapulmonary chemoreceptors (see review by Bouverot, 1978). Intrapulmonary chemoreceptors are known to be specifically sensitive to intrapulmonary PCO, Barnas, Mather & Fedde, 1978) and are thought to be capable of adjusting respiratory pattern on a breath-to-breath basis (Miller & Kunz, 1977;Scheid, Gratz, Powell & Fedde 1978;Berger, Tallman & Kunz, 1980;Tallman & Kunz, 1982). Available evidence suggests the intrapulmonary chemoreceptors are located most abundantly in the area of the mediodorsal secondary bronchi (Burger, Osborne & Banzett, 1974;.…”

Section: Discussionmentioning

confidence: 99%

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Gleeson

Brackenbury

1983

Exp Physiol

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SUMMARYGaseous exchange, ventilatory pattern and gas levels within the interclavicular and abdominal air sacs of domestic fowl were monitored before, during and after periods of moderate hyperthermic panting. 02 consumption (Vo2) remained virtually unaltered and CO2 production (Vco,) Changes in gas levels within the lung-air sac system are discussed in connexion with the peripheral control of ventilation during panting.

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Section: Discussionmentioning

confidence: 99%

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Gleeson

Brackenbury

1983

Exp Physiol

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“…population recorded in the domestic fowl in the present study is very similar to that previously determined in the decerebrate or anaesthetized duck (cf. Fedde & Scheid, 1976;Berger et al 1980;Tallman & Grodins, 1982). A consistent characteristic of recordings from the majority of i.p.c.…”

Section: Discussionmentioning

confidence: 98%

“…The analysis of i.p.c. discharge was done according to the bin-averaging technique that has been applied to these receptors in previous studies in the duck (Fedde & Scheid, 1976;Berger et al 1980;Tallman & Grodins, 1982). Briefly, this technique divides inspiration into 10 bins of equal duration and calculates the discharge frequency within each bin (Fig.…”

Section: Single-unit Recording and Analysismentioning

confidence: 99%

“…In spontaneously breathing decerebrate or anaesthetized birds (ducks and domestic fowl) the eupnoeic firing patterns of the i.p.c. have been described (Molony, 1974;Fedde & Scheid, 1976;Berger, Tallman & Kunz, 1980;Tallman & Grodins, 1982). However, little attention has been paid to the effects of hyperventilation or hyperpnoea and accompanying respiratory pattern adjustments on the discharge pattern of i.p.c.…”

Section: Introductionmentioning

confidence: 99%

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Changes in Intrapulmonary Chemoreceptor Discharge in Response to the Adjustment of Respiratory Pattern During Hyperventilation in Domestic Fowl

Gleeson

1985

Exp Physiol

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It has been suggested that avian vagal intrapulmonary CO2‐sensitive receptors (i.p.c.) may be capable of monitoring the rate and extent of CO2 wash‐out from the lung during spontaneous breathing. The purpose of this study was to record i.p.c. discharge activity in spontaneously breathing domestic fowl when minute volume (V1) was elevated from resting levels. This was accomplished by administration of almitrine (2 mg. kg−1 i.v.), a respiratory stimulant drug that has been shown to have a specific long‐lasting stimulatory action on carotid body chemoreceptors. Unanaesthetized decerebrate fowl were tracheotomized and single‐unit activity was recorded from sixteen vagal i.p.c. When ventilation was elevated 2·2‐fold by, almitrine (initially by increases in tidal volume (VT)) i.p.c. discharge was increased in both inspiration and expiration, and the delay period before the onset of i.p.c. discharge in inspiration was markedly shortened. Within 5‐10 min after the administration of almitrine, the breathing pattern changed to one of rapid, shallow breathing, although the 2·2‐fold elevation of the rate of gas flow through the parabronchi (V) and mean inspiratory flow rate (VT/T1) were maintained. The i.p.c. continued to fire phasically, with peaks of discharge in both inspiration and expiration, though there were fewer spikes per breath and mean inspiratory peak discharge rate returned to control (eupnoeic) levels. It is concluded that i.p.c. discharge is increased when V1 is elevated in the spontaneously breathing fowl and that the pattern of discharge is dependent on the pattern of breathing. I.p.c. show high dynamic sensitivity to changes in the PC02 of their microenvironment and it is possible to explain the changes in discharge pattern observed in terms of the PCO2 changes in the lungs and air sacs. These results support proposals that the pattern of breathing is to some extent dependent upon the intensity and timing of i.p.c. activity.

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“…The action potential discharge of IPCs responds to both rapidly changing (i.e., phasic) and sustained (or tonic) levels of intrapulmonary PCO 2 , thereby encoding information about the temporal relationships between ventilation, perfusion, and metabolism (4,9,15,16,19,24,34). IPC sensory feedback helps terminate inspiration by sensing CO 2 washout from the lung, helps maintain arterial homeostasis in response to moderate inspired hypercapnia (35,37,45), and helps adjust breathing to metabolic demands (4,9,19,24,50).IPC are unusual respiratory chemoreceptors because their action potential discharge rate is inversely proportional to intrapulmonary PCO 2 . Low PCO 2 stimulates IPC firing, and high PCO 2 inhibits firing (9, 15, 16); thus the IPC response is backward compared with that of traditional respiratory chemoreceptors like the carotid bodies (18, 29), many presumptive central chemoreceptors (40), and snail pneumostome ganglia chemoreceptors (13,14).…”

mentioning

confidence: 99%

CO₂transduction in avian intrapulmonary chemoreceptors is critically dependent on transmembrane Na⁺/H⁺exchange

Hempleman

Adamson

Begay

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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R1551-R1559, 2003. First published February 20, 2003 10.1152/ajpregu.00519.2002Avian intrapulmonary chemoreceptors (IPC) are vagal respiratory afferents that are inhibited by high lung PCO 2 and excited by low lung PCO 2. Previous work suggests that increased CO 2 inhibits IPC by acidifying intracellular pH (pHi) and that pH i is determined by a kinetic balance between the rate of intracellular carbonic anhydrase-catalyzed CO 2 hydration/dehydration and transmembrane extrusion of acids and/or bases by various exchangers. Here, the role of amiloride-sensitive Na ϩ /H ϩ exchange (NHE) in the IPC CO2 response was tested by recording single-unit action potentials from IPC in anesthetized ducks, Anas platyrhynchos. For each of the IPC tested, blockade of the NHE using dimethyl amiloride (DMA) elicited a marked (Ͼ50%) dose-dependent decrease in mean IPC discharge (P Ͻ 0.05), suggesting that NHE is important for pH i regulation and CO2 transduction in IPC. In addition, activation of the NHE using 12-O-tetradecanoylphorbol 13-acetate stimulated six of the seven IPC tested, although the overall effect was not statistically significantly (P ϭ 0.07). Taken together, these findings suggest that CO 2 transduction in IPC is dependent on transmembrane NHE although it is likely to be much slower than carbonic anhydrase-catalyzed hydration-dehydration of CO2. carbon dioxide chemosensitivity; intracellular pH regulation; respiratory control; neuron; acid; base BIRDS HAVE INTRAPULMONARY chemoreceptors (IPC) that monitor lung PCO 2 and exert reflex effects on the pattern of breathing (9,15,16,36,37,43,45). These IPC have afferent axons in the vagus nerves, cell bodies in the nodose ganglia, and sensory endings in the parabronchial tissue of the lungs (9, 25, 34). The action potential discharge of IPCs responds to both rapidly changing (i.e., phasic) and sustained (or tonic) levels of intrapulmonary PCO 2 , thereby encoding information about the temporal relationships between ventilation, perfusion, and metabolism (4,9,15,16,19,24,34). IPC sensory feedback helps terminate inspiration by sensing CO 2 washout from the lung, helps maintain arterial homeostasis in response to moderate inspired hypercapnia (35,37,45), and helps adjust breathing to metabolic demands (4,9,19,24,50).IPC are unusual respiratory chemoreceptors because their action potential discharge rate is inversely proportional to intrapulmonary PCO 2 . Low PCO 2 stimulates IPC firing, and high PCO 2 inhibits firing (9, 15, 16); thus the IPC response is backward compared with that of traditional respiratory chemoreceptors like the carotid bodies (18, 29), many presumptive central chemoreceptors (40), and snail pneumostome ganglia chemoreceptors (13,14). Many presumptive chemoreceptor neurons located in the mammalian medullary raphe, however, have also been shown to be inhibited by high PCO 2 (41, 54), as are reptilian IPC, mammalian pulmonary stretch receptors, and mammalian laryngeal CO 2 chemoreceptors (10,32,39,44). Thus the inverse CO 2 response (discharge rate inhi...

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Discharge of intrapulmonary chemoreceptors and its modulation by rapid FiCO2 changes in decerebrate ducks

Cited by 18 publications

References 10 publications

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Changes in Intrapulmonary Chemoreceptor Discharge in Response to the Adjustment of Respiratory Pattern During Hyperventilation in Domestic Fowl

CO₂transduction in avian intrapulmonary chemoreceptors is critically dependent on transmembrane Na⁺/H⁺exchange

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Discharge of intrapulmonary chemoreceptors and its modulation by rapid FiCO2 changes in decerebrate ducks

Cited by 18 publications

References 10 publications

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Ventilation, Gaseous Exchange and Air Sac Gases During Moderate Thermal Panting in Domestic Fowl

Changes in Intrapulmonary Chemoreceptor Discharge in Response to the Adjustment of Respiratory Pattern During Hyperventilation in Domestic Fowl

CO2transduction in avian intrapulmonary chemoreceptors is critically dependent on transmembrane Na+/H+exchange

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CO₂transduction in avian intrapulmonary chemoreceptors is critically dependent on transmembrane Na⁺/H⁺exchange