Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran

Abstract

AIMTo evaluate various schemes for paraquat poisoning and different variables that influence the outcome of acute paraquat poisoning.METHODSIn a cross-sectional study, the information about all cases of acute paraquat poisoning who were admitted to teaching hospitals affiliated to Shiraz University of Medical Sciences, in a five year period (September 2010 to September 2015) were evaluated. The variables included: Demographic data, medical assessment, therapeutic options, laboratory findings, and the outcomes. Data were analyzed using SPSS, version 22. Significant difference between groups was tested using t-test for continues outcomes and χ2 test for categorical. The significance level was considered to be P < 0.05.RESULTSA total of 104 patients (66.3% male) were evaluated. The mean age of the female patients was 22.81 ± 9.87 years and the male patients’ was 27.21 ± 11.06 years. Ninety seven (93.3%) of all the cases were suicide attempts with mortality rate of 43.2%. Despite the necessity for emergency hemodialysis during the first 6 h of intoxication, none of the patients had dialysis during this time. Immunosuppressive and corticosteroid medications were not administrated in adequate dosage in 31.1% and 60% of the patients, respectively. Ingestion of more than 22.5 cc of paraquat and increase in creatinine level were the most important predictors of mortality.CONCLUSIONTreatment should start immediately for these patients. Moreover, creating a clinical guideline according to the findings can have an impact on the treatment procedure which seems to be necessary.

Clinical features and prognosis of paraquat poisoning in French Guiana

“…Moreover, the severity and outcome of paraquat poisoning are determined primarily by the amount ingested. [ 22 , 35 , 36 ] Given all these data, how can we reduce suicide attempts by paraquat ingestion in French Guiana? Several studies have attempted to address this increasingly common problem.…”

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

“…[22] Half of the patients in the present study were male, and in other studies, males ranged between 55% and 70%. [781026] In Delirrad et al . study, the majority of the patients were male, with a male: female ratio of 1.28.…”

“…[69] Recently, Kavousi-Gharbi et al . [10] evaluated 104 cases of PQ poisoning, with a mortality rate of 43%. In many developing countries, in which the rules and regulations governing the sale and use of PQ are not strict, PQ intoxication is difficult to prevent.…”

Radiological Features of Paraquat Herbicide Poisoning: A Case Report

“…A high-risk radiologic manifestation is usually observed in the first two weeks post-poisoning as pneumothorax, pneumomediastinum, and ARDS. The fibrosis usually appears in a radiology image at about 2-4 weeks post-exposure [6].…”