Discernible effects of tDCS over the primary motor and posterior parietal cortex on different stages of motor learning

Rivera-Urbina, Guadalupe Nathzidy; Molero‐Chamizo, Andrés; Nitsche, Michael A.

doi:10.1007/s00429-021-02451-0

Cited by 7 publications

(4 citation statements)

References 101 publications

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“…In recent years, several forms of minimally invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS; Taga et al, 2019), tDCS (Rivera-Urbina et al, 2022), and binaural acoustic beat (BAB; Ross & Lopez, 2020) have been investigated as attractive nonpharmaceutical alternatives to improve or empower motor processes in patients and healthy subjects, respectively.…”

Section: Introductionmentioning

confidence: 99%

The Age-Specific Impact of Alpha-Wave Binaural Acoustic Stimulation on Motor-Learning Aptitude

Azizzadeh Herozi,

Kamali,

Shamsi

et al. 2024

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There are some reports on the impact of binaural acoustic beat (BAB) training on motor learning. The current study aimed to explain the possible influences of alpha BAB on motor learning in young and older adult individuals. To this end, 26 male participants were assigned to four parallel groups: two alpha BAB groups (young, older adults) and two control groups (young, older adults). The alpha BAB groups received alpha BAB for 30 min, whereas examinees in the control groups just wore headphones without listening to any music over the experiment period. The digital mirror-tracing task was employed to examine the subjects' motor performance simultaneously with quantitative electroencephalography and after the intervention. In the mirror-tracing task, a significant decrease in the number of errors was found only for the older adults who received alpha BAB. Meanwhile, the reaction time decreased significantly in the young Alpha BAB group. Alpha BAB was associated with a notable increase in alpha current source density dynamics in the young subjects and enhanced beta, high beta oscillations, and gamma power in the older adults. Our findings suggest that alpha BAB might improve motor performance in older adults and young individuals through different patterns.

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Section: Introductionmentioning

confidence: 99%

The Age-Specific Impact of Alpha-Wave Binaural Acoustic Stimulation on Motor-Learning Aptitude

Azizzadeh Herozi,

Kamali,

Shamsi

et al. 2024

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“…Biperiden has a high affinity for the M1 receptor (Bolden et al, 1992), which is primarily located in the hippocampus and the cerebral cortex, but also in the cerebellum, striatum and thalamus (Levey, 1993). Neuroimaging, anatomical and lesion studies have identified a cortical-subcortical network underpinning procedural learning, engaging a frontalparietal network (Eliassen et al, 2001;Hardwick et al, 2013;Müller et al, 2002;Rivera-Urbina et al, 2022;Tzvi et al, 2016) and the motor cortex, cerebellum, basal ganglia and ventral intermediate nucleus of the thalamus (Hardwick et al, 2013;Roy et al, 2019;Terzic et al, 2022;Voegtle et al, 2022Voegtle et al, , 2023. The presence of M1 receptors in the network underpinning procedural learning suggests a potential impact of biperiden on motor learning.…”

Section: Introductionmentioning

confidence: 99%

Cholinergic modulation of motor sequence learning

Voegtle,

Mohrbutter,

Hils

et al. 2024

Eur J of Neuroscience

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The cholinergic system plays a key role in motor function, but whether pharmacological modulation of cholinergic activity affects motor sequence learning is unknown. The acetylcholine receptor antagonist biperiden, an established treatment in movement disorders, reduces attentional modulation, but whether it influences motor sequence learning is not clear. Using a randomized, double‐blind placebo‐controlled crossover design, we tested 30 healthy young participants and showed that biperiden impairs the ability to learn sequential finger movements, accompanied by widespread oscillatory broadband power changes (4–25 Hz) in the motor sequence learning network after receiving biperiden, with greater power in the theta, alpha and beta bands over ipsilateral motor and bilateral parietal–occipital areas. The reduced early theta power during a repeated compared with random sequence, likely reflecting disengagement of top‐down attention to sensory processes, was disrupted by biperiden. Alpha synchronization during repeated sequences reflects sensory gating and lower visuospatial attention requirements compared with visuomotor responses to random sequences. After biperiden, alpha synchronization was greater, potentially reflecting excessive visuospatial attention reduction, affecting visuomotor responding required to enable sequence learning. Beta oscillations facilitate sequence learning by integrating visual and somatosensory inputs, stabilizing repeated sequences and promoting prediction of the next stimulus. The beta synchronization after biperiden fits with a disruption of the selective visuospatial attention enhancement associated with initial sequence learning. These findings highlight the role of cholinergic processes in motor sequence learning.

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“…For example, tDCS stimulation over the primary motor cortex (M1) has been shown to increase learning when applied during the task (e.g. 27,28), whereas tDCS applied over parietal cortex enhances later stages of consolidation (29).…”

Section: Introductionmentioning

confidence: 99%

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning impairments in schizophrenia.

Javitt

Sehatpour

Kreither³

et al. 2023

Preprint

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Motor learning is a fundamental skill to our daily lives. Dysfunction in motor performance in schizophrenia (Sz) is associated with poor social and functional outcomes, but nevertheless remains understudied relative to other neurocognitive domains. Moreover, transcranial direct current stimulation (tDCS) can influence underlying brain function in Sz and may be especially useful in enhancing local cortical plasticity, but underlying neural mechanisms remain incompletely understood. Here, we evaluated performance of Sz individuals on the Serial Reaction Time Task (SRTT), which has been extensively used in prior tDCS research, in combination with concurrent tDCS and EEG source localization first to evaluate the integrity of visuomotor learning in Sz relative to other cognitive domains and second to investigate underlying neural mechanisms. Twenty-seven individuals with Sz and 21 healthy controls (HC) performed the SRTT task as they received sham or active tDCS and simultaneous EEG recording. Measures of motor, neuropsychological and global functioning were also assessed. Impaired SRTT performance correlated significantly with deficits in motor performance, working memory, and global functioning. Time-frequency (“Beamformer”) EEG source localization showed beta-band coherence across supplementary-motor, primary-motor and visual cortex regions, with reduced visuomotor coherence in Sz relative to HC. Cathodal tDCS targeting both visual and motor regions resulted in significant modulation in coherence particularly across the motor-visual nodes of the network accompanied by significant improvement in motor learning in both controls and patients. Overall, these findings demonstrate the utility of the SRTT to study mechanisms of visuomotor impairment in Sz and demonstrate significant tDCS effects on both learning and connectivity when applied over either visual or motor regions. The findings support continued study of dysfunctional dorsal-stream visual connectivity and motor plasticity as components of cognitive impairment in Sz, of local tDCS administration for enhancement of plasticity, and of source-space EEG-based biomarkers for evaluation of underlying neural mechanisms.

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Discernible effects of tDCS over the primary motor and posterior parietal cortex on different stages of motor learning

Cited by 7 publications

References 101 publications

The Age-Specific Impact of Alpha-Wave Binaural Acoustic Stimulation on Motor-Learning Aptitude

The Age-Specific Impact of Alpha-Wave Binaural Acoustic Stimulation on Motor-Learning Aptitude

Cholinergic modulation of motor sequence learning

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning impairments in schizophrenia.

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