DISC1 overexpression promotes non-small cell lung cancer cell proliferation

Wang, Shuo; Chen, Yingying; Li, Yupeng; J, Gu; Gu, Shudong; Shi, Hai; Li, Xuesong; Lu, Xin; Li, Xiang; Zhang, Shuanglong; Yu, Kang-Jun; Liu, Kun; Ji, Lili

doi:10.18632/oncotarget.18055

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…Although DISC1 expression was not associated with the mean postoperative survival time in this study, it (like DAXX and DRD3) was related strongly to CS progression, indicating its utility as a biomarker. This finding is in agreement with Wang et al (2017), who reported that DISC1 promotes non-small cell lung cancer growth, probably through the GSK3β/β-catenin signaling pathway. Moreover, in glioblastoma, knockdown of DISC1 was found to significantly inhibit cell proliferation, migration, and invasion in vitro and in vivo (Gao et al, 2016).…”

Section: Discussionsupporting

confidence: 93%

“…DISC1 is an important cell proliferation regulator that positively modulates Wnt signaling via the inhibition of GSK3β catalytic activity and activation of β-catenin (Brandon et al, 2009). GSK3β/β-catenin signaling pathway has been found to be associated with the pathogenesis of cancers (Wan et al, 2015; Wang et al, 2017). Another important mechanism of DISC1 is its regulation of the cAMP-signaling pathway, which has been demonstrated to be associated strongly with cancer pathogenesis and promotion (Simko et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…DISC1, associated with a variety of brain disorders, activates Wnt/β-catenin signaling by inhibiting glycogen synthase kinase 3 beta (GSK3β) phosphorylation, and promotes neural progenitor cell proliferation. Aberrations in the GSK3β/β-catenin signaling pathway have been associated with the pathogenesis of liver and lung cancers (Wan et al, 2015; Wang et al, 2017). Gao et al who first identified DISC1 as an oncogene in glioblastoma tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Shi

Chen

et al. 2019

Front. Mol. Biosci.

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Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health–related proteins have been associated with the pathogenesis, progression, and prognosis of many cancers, but their association with chondrosarcoma has not been reported. In this study, the expression and clinicopathological significance of the mental health–related proteins DAXX, DRD3, and DISC1 in chondrosarcoma tissue samples were examined, over an 84-months follow-up period. In immunohistochemical analysis, the rates of positive DAXX, DRD3, and DISC1 expression were significantly higher in chondrosarcoma than in osteochondroma tissue (P < 0.01). The percentages of positive DAXX, DRD3, and DISC1 expression were significantly lower in tissues with good differentiation (P < 0.01), AJCC stage I/ II (P < 0.01), Enneking stage I (P < 0.01), and non-metastasis (P < 0.05), respectively. In Kaplan–Meier survival analysis, significantly shorter mean survival times were associated with moderate and poor differentiation (P = 0.000), AJCC stage III/IV (P = 0.000), Enneking stage II/III (P = 0.000), metastasis (P = 0.019), invasion (P = 0.013), and positive DAXX (P = 0.012), and/or DRD3 (P = 0.018) expression. In Cox regression analysis, moderate and poor differentiation (P = 0.006), AJCC stage III/IV (P = 0.013), Enneking stage II/III (P = 0.016), metastasis (P = 0.033), invasion (P = 0.011), and positive DAXX (P = 0.033), and/or DRD3 (P = 0.025) staining correlated negatively with the postoperative survival rate and positively with mortality. In competing-risks regression analysis, differentiation (P = 0.005), metastasis (P = 0.014), invasion (P = 0.028), AJCC stage (P = 0.003), Enneking stage (P = 0.036), and DAXX (P = 0.039), and DRD3(P = 0.019) expression were independent predictors of death from chondrosarcoma. The areas under receiver operating characteristic curves for DAXX, DRD3, and DISC1 expression were 0.673 (95% CI, 0.557–0.788; P = 0.010), 0.670 (95% CI, 0.556–0.784; P = 0.011), and 0.688 (95% CI, 0.573–0.802; P = 0.005), respectively. These results suggest that DAXX, DRD3, and DISC1 could serve as biomarkers of chondrosarcoma progression and predictors of its prognosis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Shi

Chen

et al. 2019

Front. Mol. Biosci.

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“…Gene silencing of NOS1AP expression could disrupt downstream pathways within the lung related to autophagy and apoptosis (49). Like CA10, DISC1 has ties to both pulmonary disease and viral infections (50,51). CWC22, a regulator of mRNA splicing and RNA metabolism, does not have a direct link to BCoV or BRD infection.…”

Section: Discussionmentioning

confidence: 99%

Identifying Loci Associated With Bovine Corona Virus Infection and Bovine Respiratory Disease in Dairy and Feedlot Cattle

Kiser

Neibergs

2021

Front. Vet. Sci.

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Bovine coronavirus (BCoV) is associated with respiratory and enteric infections in both dairy and beef cattle worldwide. It is also one of a complex of pathogens associated with bovine respiratory disease (BRD), which affects millions of cattle annually. The objectives of this study were to identify loci and heritability estimates associated with BCoV infection and BRD in dairy calves and feedlot cattle. Dairy calves from California (n = 1,938) and New Mexico (n = 647) and feedlot cattle from Colorado (n = 915) and Washington (n = 934) were tested for the presence of BCoV when classified as BRD cases or controls following the McGuirk scoring system. Two comparisons associated with BCoV were investigated: (1) cattle positive for BCoV (BCoV+) were compared to cattle negative for BCoV (BCoV−) and (2) cattle positive for BCoV and affected with BRD (BCoV+BRD+) were compared to cattle negative for BCoV and BRD (BCoV−BRD−). The Illumina BovineHD BeadChip was used for genotyping, and genome-wide association analyses (GWAA) were performed using EMMAX (efficient mixed-model association eXpedited). The GWAA for BCoV+ identified 51 loci (p < 1 × 10−5; 24 feedlot, 16 dairy, 11 combined) associated with infection with BCoV. Three loci were associated with BCoV+ across populations. Heritability estimates for BCoV+ were 0.01 for dairy, 0.11 for feedlot cattle, and 0.03 for the combined population. For BCoV+BRD+, 80 loci (p < 1 × 10−5; 26 feedlot, 25 dairy, 29 combined) were associated including 14 loci across populations. Heritability estimates for BCoV+BRD+ were 0.003 for dairy, 0.44 for feedlot cattle, and 0.07 for the combined population. Several positional candidate genes associated with BCoV and BRD in this study have been associated with other coronaviruses and respiratory infections in humans and mice. These results suggest that selection may reduce susceptibility to BCoV infection and BRD in cattle.

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Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3β/β-catenin pathway

Zhai

Shi

et al. 2020

European Journal of Pharmacology

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DISC1 overexpression promotes non-small cell lung cancer cell proliferation

Cited by 9 publications

References 27 publications

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Identifying Loci Associated With Bovine Corona Virus Infection and Bovine Respiratory Disease in Dairy and Feedlot Cattle

Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3β/β-catenin pathway

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