Disc Regeneration with Platelets and Growth Factors

Bodor, Marko; Toy, Andrew; Aufiero, Danielle

doi:10.1007/978-3-642-40117-6_14

Cited by 15 publications

(11 citation statements)

References 35 publications

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“…A list of excluded articles was given in Supplementary File 2. Finally, 12 studies including 2 RCTs 15,22 , 5 prospective studies [23][24][25][26][27] , and 5 retrospective studies [28][29][30][31][32] having a total of 317 patients were included in our analysis. At a glance, PRISMA flow diagram of study selection has been depicted as Figure 1 and general characteristics of the studies included in our meta-analysis have been elucidated in Table 1.…”

Section: Search Resultsmentioning

confidence: 99%

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Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Muthu

Jeyaraman

Chellamuthu

et al. 2021

Global Spine Journal

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Study Design: Systematic review and meta-analysis. Objectives: We performed this meta-analysis to evaluate whether intradiscal Platelet Rich Plasma(PRP) injection has any beneficial role in the management of lumbar disc disease. Methods: We conducted independent and duplicate electronic database searches including PubMed, Embase, and Cochrane Library till September 2020 for studies investigating the role of intradiscal PRP in the management of lumbar disc disease. The analysis was performed in the R platform using OpenMeta[Analyst] software. Results: 13 studies including 2 RCTs, 5 prospective, and 6 retrospective studies involving 319 patients were included in the meta-analysis. A single-arm meta-analysis of the included studies showed a beneficial effect of the intervention in terms of pain relief outcomes like VAS score (p < 0.001), pain component of SF-36 (p = 0.003) while such improvement was not seen in functional outcome measures like ODI score (p = 0.071), the physical component of SF-36 (p = 0.130) with significant heterogeneity noted among the included studies. No structural improvement in magnetic resonance imaging was observed (p = 0.106). No additional procedure-related adverse events were noted in the included studies (p = 0.662). Conclusion: There is a paucity of high-quality studies to give conclusive evidence on the benefits of intradiscal PRP for lumbar disc disease. Although intradiscal PRP injection has shown some beneficial effect in controlling pain for lumbar disc disease, we could not find structural or functional improvement from the included studies. Hence, we recommend large double-blind double-arm randomized controlled studies to analyze the benefits of the intervention being analyzed.

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Section: Search Resultsmentioning

confidence: 99%

“…3 prospective studies [23][24][25] and 1 retrospective study 32 involving 97 patients reported ODI scores at the final follow-up. The mean ODI score in the included patients pre-intervention was 35.35 which reduced to 22.25 at the final follow-up postintervention.…”

Section: Odi Score At Final Follow-upmentioning

confidence: 99%

Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Muthu

Jeyaraman

Chellamuthu

et al. 2021

Global Spine Journal

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“…Bodor et al [ 44 ] injected PRP excluding leukocytes and erythrocytes into 47 thoracic or lumbar IVDs in 35 patients, and no activators were used for the PRP. The numerical rating scales (NRS) and the Oswestry Disability Index (ODI) scores were improved in 67% of the patients.…”

Section: Clinical Trials Of Prpmentioning

confidence: 99%

Effect of Platelet-Rich Plasma on Intervertebral Disc Degeneration In Vivo and In Vitro: A Critical Review

Chang

Yang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Intervertebral disc degeneration (IDD) is a globally occurring disease that represents a significant cause of socioeconomic problems. Currently, the main method for treating IDD is surgery, including discectomy and vertebral fusion. Several in vitro experiments demonstrated that platelet-rich plasma (PRP) could stimulate cell proliferation and extracellular matrix regeneration. Additionally, in vivo experiments have proven that PRP injection could restore intervertebral disc height. Clinical studies demonstrated that PRP injection could significantly relieve patient pain. However, further studies are still required to clarify the roles of PRP in IDD prevention and treatment. This review is aimed at summarizing and critically analyzing the current evidence regarding IDD treatment with PRP.

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“…Bodor et al73 included case examples in their book chapters. These authors performed intradiscal PRP injections for 47 thoracic or lumbar discs of 35 patients 73.…”

Section: Clinical Studies Of Prp For Lbp Patientsmentioning

confidence: 99%

“…Bodor et al73 included case examples in their book chapters. These authors performed intradiscal PRP injections for 47 thoracic or lumbar discs of 35 patients 73. PRP without leukocytes or erythrocytes was prepared using a commercial kit (Cascade Autologous Platelet System; ConMed Linvatec; MTF biologics, Edison, NJ, USA), and no activators (CaCl 2 or thrombin) were used.…”

Section: Clinical Studies Of Prp For Lbp Patientsmentioning

confidence: 99%

<p>Platelet-rich plasma in the management of chronic low back pain: a critical review</p>

Akeda¹,

Yamada²,

Linn³

et al. 2019

JPR

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Low back pain (LBP) is now regarded as the first cause of disability worldwide and should be a priority for future research on prevention and therapy. Intervertebral disc (IVD) degeneration is an important pathogenesis of LBP. Platelet-rich plasma (PRP) is an autologous blood concentrate that contains a natural concentration of autologous growth factors and cytokines and is currently widely used in the clinical setting for tissue regeneration and repair. PRP has great potential to stimulate cell proliferation and metabolic activity of IVD cells in vitro. Several animal studies have shown that the injection of PRP into degenerated IVDs is effective in restoring structural changes (IVD height) and improving the matrix integrity of degenerated IVDs as evaluated by magnetic resonance imaging (MRI) and histology. The results of this basic research have shown the great possibility that PRP has significant biological effects for tissue repair to counteract IVD degeneration. Clinical studies for evaluating the effects of the injection of PRP into degenerated IVDs for patients with discogenic LBP have been reviewed. Although there was only one double-blind randomized controlled trial, all the studies reported that PRP was safe and effective in reducing back pain. While the clinical evidence of tissue repair of IVDs by PRP treatment is currently lacking, there is a great possibility that the application of PRP has the potential to lead to a feasible intradiscal therapy for the treatment of degenerative disc diseases. Further large-scale studies may be required to confirm the clinical evidence of PRP for the treatment of discogenic LBP.

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Disc Regeneration with Platelets and Growth Factors

Cited by 15 publications

References 35 publications

Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Effect of Platelet-Rich Plasma on Intervertebral Disc Degeneration In Vivo and In Vitro: A Critical Review

<p>Platelet-rich plasma in the management of chronic low back pain: a critical review</p>

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