Disc degeneration implies low back pain

Zheng, Chang-Jiang; Chen, James

doi:10.1186/s12976-015-0020-3

Cited by 72 publications

(59 citation statements)

References 19 publications

(24 reference statements)

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“…A major cause of low back pain is the degeneration of the Intervertebral Disc (IVD) . The IVD consists of three parts in one functional unit: a gelatinous center called the nucleus pulposus (NP), an outer fibrocartilaginous ring called the annulus fibrosus (AF), and top and bottom caps called the cartilaginous endplates (EPs) .…”

Section: Introductionmentioning

confidence: 99%

“…3 A major cause of low back pain is the degeneration of the Intervertebral Disc (IVD). 4 The IVD consists of three parts in one functional unit: a gelatinous center called the nucleus pulposus (NP), an outer fibrocartilaginous ring called the annulus fibrosus (AF), and top and bottom caps called the cartilaginous endplates (EPs). 5 Degeneration of the IVD is a complex pathological process characterized by a loss of hydration, changes in cell populations, a decrease in protein and polysaccharide concentrations and altered biomechanical properties.…”

Section: Introductionmentioning

confidence: 99%

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A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model

et al. 2019

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Introduction Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use. Methods As part of a prior study, 25 New Zealand white rabbits underwent annular puncture to induce disc degeneration in 50 noncontiguous lumbar discs. At 16 weeks, the animals underwent multi‐echo T2 MRI scanning and were euthanized. The discs were stained and examined histologically. Quantitative T2 relaxation maps were prepared using the nonlinear least squares method. Decay Variance maps were created using a novel technique of aggregating the deviation in the intensity of each echo signal from the expected intensity based on the previous rate of decay. Results Decay Variance maps showed a clear and well demarcated nucleus pulposus with a consistent rate of decay (low Decay Variance) in healthy discs that showed progressively more variable decay (higher Decay Variance) with increasing degeneration. Decay Variance maps required significantly less time to generate (1.0 ± 0.0 second) compared with traditional T2 relaxometry maps (5 (±0.9) to 1788.9 (±116) seconds). Histology scores correlated strongly with Decay Variance scores (r = 0.82, P < .01) and weakly with T2 signal intensity (r = 0.32, P < .01) and quantitative T2 relaxometry (r = 0.39, P < .01). Decay Variance had superior sensitivity and specificity for the detection of degenerate discs when compared to T2 signal intensity or Quantitative T2 mapping. Conclusion Our results show that using a multi‐echo T2 MRI sequence, Decay Variance can quantitatively assess disc degeneration more accurately and with less image‐processing time than quantitative T2 relaxometry in a rabbit disc puncture model. The technique is a viable candidate for quantitative assessment of disc degeneration on MRI scans. Further validation on human subjects is needed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model

et al. 2019

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“…Lumbar intervertebral disc degeneration is the most common cause of low back pain [2]. The pathological process of intervertebral disc degeneration mainly involves dehydration and fibrosis of the nucleus pulposus (NP), tearing of the annulus fibrosus, and sclerosis of the cartilage endplate [3,4].…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Expression of High Temperature Requirement Serine Protease A1 (HtrA1) in Nucleus Pulposus and T2 Value of Magnetic Resonance Imaging

Yue

Jiang

et al. 2017

Med Sci Monit

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BackgroundDegrading enzymes play an important role in the process of disc degeneration. The objective of this study was to investigate the correlation between the expression of high temperature requirement serine protease A1 (HtrA1) in the nucleus pulposus and the T2 value of the nucleus pulposus region in magnetic resonance imaging (MRI).Material/MethodsThirty-six patients who had undergone surgical excision of the nucleus pulposus were examined by MRI before surgery. Pfirrmann grading of the target intervertebral disc was performed according to the sagittal T2-weighted imaging, and the T2 value of the target nucleus pulposus was measured according to the median sagittal T2 mapping. The correlation between the Pfirrmann grade and the T2 value was analyzed. The expression of HtrA1 in the nucleus pulposus was analyzed by RT-PCR and Western blot. The correlation between the expression of HtrA1 and the T2 value was analyzed.ResultsThe T2 value of the nucleus pulposus region was 33.11–167.91 ms, with an average of 86.64±38.73 ms. According to Spearman correlation analysis, there was a rank correlation between T2 value and Pfirrmann grade (P<0.0001), and the correlation coefficient (rs)=−0.93617. There was a linear correlation between the mRNA level of HtrA1 and T2 value in nucleus pulposus tissues (a=3.88, b=−0.019, F=112.63, P<0.0001), normalized regression coefficient=−0.88. There was a linear correlation between the expression level of HtrA1 protein and the T2 value in the nucleus pulposus tissues (a=3.30, b=−0.016, F=93.15, P<0.0001) and normalized regression coefficient=−0.86.ConclusionsThe expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration.

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“…Degenerative disc disease (DDD) is the main cause of low back pain [1,2]. The most important factor involved in the development of DDD is the vertical load of spine, which can activate enzymatic processes facilitating discs degenerations, in addition to the purely direct (increased fluid stress and hydrostatic pressure) and indirect (decreased permeability and nutrition) mechanical effects.…”

Section: Introductionmentioning

confidence: 99%

Intervertebral Disc Changes after Vertebral Distraction Performed During Posterolateral Spine Fusion for Lumbar Segmental Instability

Du¹,

Arendt²,

Jesperesen³

et al. 2016

Spine Res

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Study Design: Analysis of intervertebral disc regeneration after disc height restoration by posterolateral spinal fusion with lumbar distraction of 68 patients diagnosed with degenerative lumbar instability. Objectives:To prove that preservation of lumbar lordosis with a simultaneous increase of intervertebral disc space and posterior intervertebral distraction can help the rehydration and regeneration of intervertebral discs.Methods: A consecutive series of 68 patients treated for degenerative lumbar instability with exclusive posterolateral spinal fusion. These patients were fused after posterior distraction of the unstable segments. Radiographic evaluation was performed pre and postoperatively by lumbar spine X-rays and MRI scans. Intervertebral disc space changes were measured at each fusion levels together with changes of lumbar lordosis. Disc water content changes were evaluated in T2-weighed sequences of postoperative MRI scans. Oswestry Disability Index was used for evaluation of the clinical outcome.

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Disc degeneration implies low back pain

Cited by 72 publications

References 19 publications

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model

Correlation Between Expression of High Temperature Requirement Serine Protease A1 (HtrA1) in Nucleus Pulposus and T2 Value of Magnetic Resonance Imaging

Intervertebral Disc Changes after Vertebral Distraction Performed During Posterolateral Spine Fusion for Lumbar Segmental Instability

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