Disaster point-of-care testing: fundamental concepts and new technologies.

Kost, Gerald J.; Curtis, Corbin M.; Louie, Richard F.; Sakaguchi, Ann; Arora, Richa; Arora, Prerna

doi:10.1079/9781845939298.0121

Cited by 3 publications

(2 citation statements)

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“…Starting at a high level of integration, Figure 13 recommends that elements of a national disaster cache [24][25][26][27][28][29] (top frame) connect (arrows) operationally and bidirectionally through SCPs (blue buttons) with SWNs (bottom frame). The same POC devices and tests available in the cache should be used on a daily basis in the SWN to (a) improve emergency care, (b) strengthen competency and preparedness, and (c) enhance response and resilience (Fig.…”

Section: Community Preparednessmentioning

confidence: 99%

Spatial Care Paths™ Strengthen Links in the Chain of Global Resilience

Kost

Ferguson

2016

Point of Care: The Journal of Near-Patient Testing &Amp; Technology

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Objective: Point of care (POC) is bogged down because of ineffective biohazard containment, insufficient environmental robustness, test clusters-cartridges unable to target rapidly emerging diseases, unpredictable errors in bedside results, dependence on misleading global parametric rather than local nonparametric statistical analysis, high marginal costs cited without assessing overall value, inadequately funded POC research, regulatory-industry intransigence, dichotomous introduction of new instruments abroad versus the United States, and meager interest in critical global challenges. The objective is to push back on these classic signs of an interrupted paradigm shift. They threaten the future of the field, this journal, and the ultimate goal, to improve medical and economic outcomes. Methods:We offer a geospatial method, Spatial Care Paths™ (SCPs), by which a portion of the future of POC can be reinvigorated interactively in cultural context. Outcomes: The Ebola epidemic revealed serious gaps in technology andswiftly changed expectations. Expectations are part of culture. Hence, the future paradigm must embrace POC culture. We provide paradigmrefreshing conceptual examples ranging from national disaster caches to diabetes care to outbreaks. We use visual logistics to illustrate the concepts and SCPs.Conclusions: By identifying weak links in the chain of community resilience, SCPs upscale key unfulfilled needs, discover new ideas for innovation-invention, bolster educational outreach, and improve patient access to evidence-based primary, emergency, and hospital care. Strong collaborative initiatives can foster activism in the global community. It is time for insightful leadership and participative outreach to bridge professional disciplines, span different countries, and steward POC into a brilliant new future.

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Section: Community Preparednessmentioning

confidence: 99%

Spatial Care Paths™ Strengthen Links in the Chain of Global Resilience

Kost

Ferguson

2016

Point of Care: The Journal of Near-Patient Testing &Amp; Technology

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“…Common sense dictates that distributing resources will enhance future resilience. Thus, POCT [10,11] has blossomed to become an innovative, ubiquitous and rapidly evolving point-of-need resource for resilience [12][13][14][15][16][17][18]. It is transforming not only disaster medicine [2], but also public health practice at points of contact worldwide.…”

Section: Enabling Public Healthmentioning

confidence: 99%

Molecular detection and point-of-care testing in Ebola virus disease and other threats: a new global public health framework to stop outbreaks

Kost¹,

Ferguson

Truong

et al. 2015

Expert Review of Molecular Diagnostics

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Ultrahigh sensitivity and specificity assays that detect Ebola virus disease or other highly contagious and deadly diseases quickly and successfully upstream in Spatial Care Paths™ can stop outbreaks from escalating into devastating epidemics ravaging communities locally and countries globally. Even had the WHO and CDC responded more quickly and not misjudged the dissemination of Ebola in West Africa and other world regions, mobile rapid diagnostics were, and still are, not readily available for immediate and definitive diagnosis, a stunning strategic flaw that needs correcting worldwide. This article strategizes point-of-care testing for diagnosis, triage, monitoring, recovery and stopping outbreaks in the USA and other countries; reviews Ebola molecular diagnostics, summarizes USA FDA emergency use authorizations and documents why they should not be stop-gaps; and reduces community risk from internal and external infectious disease threats by enabling public health at points of need.

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A Pipeline-Based Oil-Bath PCR Method for Bacteria Detection

Shi

et al. 2020

IEEE Access

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Polymerase chain reaction (PCR) technology is an essential technology for point-of-care testing (POCT) application. To realize the simple, portable and fast detection of bacteria has always been an important technology. In this paper, we developed a pipeline-based oil-bath PCR method, to achieve the PCR amplification and detection for bacteria. We assembled a small-sized system with a uniform temperature environment and a stable heating module. By comparing the PCR performance with the other two existing pipeline-based methods on the reactions of both DNA fragment of H7N9 avian influenza and Escherichia Coli, the results show that the pipeline-based oil-bath PCR method is fully capable of the amplification and detection of both DNA fragment and bacteria. At the meanwhile, we performed two sets of tests, the experiment of pipeline diameter change and bacterial concentration gradient, to verify the sensitivity and universality of this method. The results show that the pipeline-based oil-bath PCR method developed by us not only gets rid of the complicated preparations, offers advantages of simple operation, low-cost and user-friendly, but also provides a stable and portable foundation for our later work.

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Disaster point-of-care testing: fundamental concepts and new technologies.

Cited by 3 publications

References 0 publications

Spatial Care Paths™ Strengthen Links in the Chain of Global Resilience

Spatial Care Paths™ Strengthen Links in the Chain of Global Resilience

Molecular detection and point-of-care testing in Ebola virus disease and other threats: a new global public health framework to stop outbreaks

A Pipeline-Based Oil-Bath PCR Method for Bacteria Detection

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