Disassembly of Hydrophobic Photosensitizer by Biodegradable Zeolitic Imidazolate Framework-8 for Photodynamic Cancer Therapy

Xu, Dandan; You, Yi-Zhuang; Zeng, Fanyu; Wang, Yong; Liang, Chunyan; Feng, Huanhuan; Ma, Xing

doi:10.1021/acsami.8b03831

Cited by 69 publications

(44 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[8] Similarly, controlled trials were also carried out to saturated ABDA aqueous solution (100 µL) mixed with MHSTU aqueous solution (1 mg mL −1 , 100 µL). The absorption spectra of the mixture was measured after the mixture was irradiated by a laser source (FU450289MTX100-GD16, 450 nm) and kept in the dark for 0, 5, 10, 15, and 20 min, respectively.…”

Section: Mean-square-displacement and Coverage Area Analysismentioning

confidence: 99%

“…The 1 O 2 generation capability of the MHSTU motor was assessed by using ABDA (9,10-anthracenediyl-bis-(methylene)dimalonic acid) as the 1 O 2 trapped agent, and monitored by UV-vis absorption spectroscopy. [8] The absorbance of ABDA continuously decreased because part of ABDA molecules reacted with the generated 1 O 2 , which in turn reflects the amount of generated 1 O 2 in solution. First, the solution containing MHSTU (1 mg mL −1 ) and saturated ABDA was irradiated by 450 nm light (3.9 mW cm −2 ) that can excite the TAPP to generate 1 O 2 .…”

Section: O 2 Generation Capacity Assessmentmentioning

confidence: 99%

“…The absorption spectra of the mixture was measured after the mixture was irradiated by a laser source (FU450289MTX100-GD16, 450 nm) and kept in the dark for 0, 5, 10, 15, and 20 min, respectively. [8] Similarly, controlled trials were also carried out to saturated ABDA aqueous solution (100 µL) mixed with MHSTU aqueous solution (1 mg mL −1 , 100 µL). DI water (100 µL) and urea aqueous solution (50 mmol L −1 , 100 µL) mixed with saturated ABDA were kept in the dark for 0, 5, 10, 15, and 20 min as controls, respectively.…”

Section: ) Model Implementationmentioning

confidence: 99%

“…[1] The principle of PDT process relies on the energy transfered from light-excited photosensitizer to the surrounding oxygen molecules ( 3 O 2 ) to generate cytotoxic/reactive oxidant species (ROS) of singlet oxygen ( 1 O 2 ) for effective cancer cells or bacteria killing. [5] Nanotechnology, in particular mesoporous nanomaterial based nanocarriers such as mesoporous silica [6] and metal-organic framework (MOF), [7,8] has been employed to solve the problem of poor water solubility of photosensitizers, which helps to prevent the selfaggregation induced photodynamic quenching. [5] Nanotechnology, in particular mesoporous nanomaterial based nanocarriers such as mesoporous silica [6] and metal-organic framework (MOF), [7,8] has been employed to solve the problem of poor water solubility of photosensitizers, which helps to prevent the selfaggregation induced photodynamic quenching.…”

Section: Introductionmentioning

confidence: 99%

“…[2] Although PDT has achieved significant progress in both research and clinical application, several physical limitations have greatly impeded the therapeutic efficacy of the PDT process, including the availability of 3 O 2 molecules nearby photosensitizers [3] and short diffusion range of 1 O 2 , [4] as well as poor water solubility of most highly efficient photosensitizer molecules. [5] Nanotechnology, in particular mesoporous nanomaterial based nanocarriers such as mesoporous silica [6] and metal-organic framework (MOF), [7,8] has been employed to solve the problem of poor water solubility of photosensitizers, which helps to prevent the selfaggregation induced photodynamic quenching. Additionally, researchers have endeavored to increase oxygen generation and/or diminish oxygen dependence by in situ reaction on nanocarriers to overcome hypoxia for efficient PDT.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Zhou

Chen

et al. 2019

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT) functions when the light-excited photosensitizers transfer energy to oxygen molecules ( 3 O 2 ) to produce cytotoxic singlet oxygen ( 1 O 2 ) that can effectively kill cells or bacteria. However, the PDT efficacy is often reduced by the limited availability of 3 O 2 surrounding the photosensitizer and extremely short diffusion range of the photoactivated 1 O 2 . Herein, an enzymatic micromotor based on hollow mesoporous SiO 2 (mSiO 2 ) microspheres is constructed as a mobile and highly efficient photosensitizer platform. Carboxylated magnetic nanoparticles are connected with both hollow spheres and 5,10,15,20-tetrakis(4-aminophenyl)porphyrin molecules through covalent linkage between amino and carboxylic groups within a one-step reaction. Due to the intrinsic asymmetry of the mSiO 2 spheres, the micromotors can be propelled by ionic diffusiophoresis induced by the enzymatic decomposition of urea. Via numerical simulation, the self-propulsion mechanism is clarified and the movement direction is identified. By virtue of active self-propulsion, the current system can overcome the long-standing shortcomings of PDT and significantly enhance the PDT efficacy by improving the accessibility of the photosensitizer to 3 O 2 and enlarging the diffusing range of 1 O 2 . Therefore, by proposing a new solution to the bottleneck problems of PDT, this work provides insightful perspectives to the biomedical application of multifunctional micro/nanomotors. applications, including targeted drug delivery, mini-surgery, biochemical sensing, and diagnostics. [13][14][15] In particular, MNMs as active carriers with the capability of cargo loading and controllable motion have great potentials for effective delivery of different types of cargos. [15] So far, researchers have also explored stimuli-responsive materials, [16][17][18][19] biomimetic materials, [20][21][22] and micro-organisms functionalized with nanomaterials [23] as MNMs to precisely transport cargos of drugs, [16,20,23,24] proteins, [18,22,25] and genes [19] in vitro and/or in vivo. Compared with traditional passive delivery, MNMs can perform tasks such as controlled navigation, rapid transportation, and active delivery of payloads to disease sites, and thus have paved way for on demand biomedical cargo transportation. [15] Inspired by these achievements, we envision that self-propelled MNMs can serve as a mobile photosensitizer platform to improve the availability of 3 O 2 as well as the diffusion range of 1 O 2 , which can consequently achieve highly efficient PDT process.

show abstract

Section: Mean-square-displacement and Coverage Area Analysismentioning

confidence: 99%

Section: O 2 Generation Capacity Assessmentmentioning

confidence: 99%

Section: ) Model Implementationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Zhou

Chen

et al. 2019

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

show abstract

Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

Zhu

et al. 2019

Adv Funct Materials

237

186

View full text Add to dashboard Cite

A growth in the use of antibiotics and the related evolution of patients' drug resistance calls for an urgent response for the development of novel curing approaches without using synthetic antibiotics. Here, the fabrication of a lowcost cryogel for wound dressing applications is demonstrated. The cryogel is composed of only naturally derived components, including chitosan/silk fibroin as the scaffold and tannic acid/ferric ion (TA/Fe 3+ ) as the stimuliresponsive agent for photothermal therapy. Based on the multiple weak hydrogen bonds and metal ligand coordination, the cryogel exhibits good flexibility and recoverability. Its highly porous structure renders the cryogel to be strongly hygroscopic to absorb blood for hemostasis. The cryogel exhibits excellent antibacterial activity to both Gram-negative and positive bacteria, benefiting from the high photothermal transition activity of the TA/Fe 3+ complex. Furthermore, the cryogel can efficiently promote cell proliferation in vitro. Significantly, animal experiments also reveal that the cryogel effectively eradicate microbes at the wound and accelerate the wound healing process. In summary, this novel biorenewable cryogel demonstrates excellent hygroscopic and hemostatic performance, photothermal antimicrobial activity, and accelerates skin regeneration, which has great application potential as a promising wound dressing material in the clinical use.

show abstract

Energy‐Free, Singlet Oxygen‐Based Chemodynamic Therapy for Selective Tumor Treatment without Dark Toxicity

Chen

Deng

Liu

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

Traditional singlet oxygen‐based antitumor therapies have been burdened with the necessity of external energy (e.g., light and ultrasound) and harmful dark toxicity. Ascorbate at the pharmacological concentration could accumulate hydrogen peroxide only in the tumor site. It is postulated that the concurrent delivery of ascorbate and nanoparticulate hypochlorous ion (ClO−) could produce singlet oxygen at the tumor site as an energy‐free, tumor‐specific therapy. The ClO− is loaded in a hybrid core–shell nanocarrier consisting of a zeolitic imidazolate framework and amphiphilic poloxamer 188. Intracellular singlet oxygen production is verified in 4T1 cells by the cooperation between hybrid nanocarriers and ascorbate, which induces significant apoptotic cell death. Upon intravenous nanocarriers delivery plus intraperitoneal ascorbate administration to xenograft mice, the in vivo antitumor efficacy of this cooperative nanomedicine is demonstrated without noticeable side‐effects. This work demonstrates a proof‐of‐concept of singlet oxygen‐based chemodynamic therapy for selective tumor eradication, which produces a novel trigger‐free, singlet oxygen‐based cancer therapy without the side effects of traditional photodynamic and sonodynamic therapy.

show abstract

Disassembly of Hydrophobic Photosensitizer by Biodegradable Zeolitic Imidazolate Framework-8 for Photodynamic Cancer Therapy

Cited by 69 publications

References 39 publications

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

Energy‐Free, Singlet Oxygen‐Based Chemodynamic Therapy for Selective Tumor Treatment without Dark Toxicity

Contact Info

Product

Resources

About