Disassembly and spreading of magnetic nanoparticle clusters on uneven surfaces

Wang, Qianqian; Yu, Jiangfan; Yuan, Kangze; Yang, Lidong; Jin, Dongdong; Zhang, Li

doi:10.1016/j.apmt.2019.100489

Cited by 48 publications

(44 citation statements)

References 57 publications

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“…2F ). By applying a precessing field (i.e., tilting the orientation of N-S poles), the induced magnetic repulsion between nanoparticle chains enlarged the coverage area of nanoparticles ( t = 15 to 33 s) ( 30 ). A rotating field was then applied to regather the nanoparticles, and a microswarm was formed ( t = 49 s), demonstrating a reversible spreading-regathering process (movie S1).…”

Section: Resultsmentioning

confidence: 99%

Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery

et al. 2021

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Swarming micro/nanorobots offer great promise in performing targeted delivery inside diverse hard-to-reach environments. However, swarm navigation in dynamic environments challenges delivery capability and real-time swarm localization. Here, we report a strategy to navigate a nanoparticle microswarm in real time under ultrasound Doppler imaging guidance for active endovascular delivery. A magnetic microswarm was formed and navigated near the boundary of vessels, where the reduced drag of blood flow and strong interactions between nanoparticles enable upstream and downstream navigation in flowing blood (mean velocity up to 40.8 mm/s). The microswarm-induced three-dimensional blood flow enables Doppler imaging from multiple viewing configurations and real-time tracking in different environments (i.e., stagnant, flowing blood, and pulsatile flow). We also demonstrate the ultrasound Doppler–guided swarm formation and navigation in the porcine coronary artery ex vivo. Our strategy presents a promising connection between swarm control and real-time imaging of microrobotic swarms for localized delivery in dynamic environments.

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Section: Resultsmentioning

confidence: 99%

Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery

et al. 2021

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“…The abovementioned advantages make magnetic actuation the preferred strategy for driving microactuators [ 58 ]. A large amount of exploratory work has been done and continues to be carried forward [ 42 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. The marriage of the magnetic driving method and TPP, which features precise and designable 3D shapes for microstructures, provides a new platform for the research of magnetron microactuators.…”

Section: Stimulus Methods Of Microactuatorsmentioning

confidence: 99%

Tethered and Untethered 3D Microactuators Fabricated by Two-Photon Polymerization: A Review

et al. 2021

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Microactuators, which can transform external stimuli into mechanical motion at microscale, have attracted extensive attention because they can be used to construct microelectromechanical systems (MEMS) and/or microrobots, resulting in extensive applications in a large number of fields such as noninvasive surgery, targeted delivery, and biomedical machines. In contrast to classical 2D MEMS devices, 3D microactuators provide a new platform for the research of stimuli-responsive functional devices. However, traditional planar processing techniques based on photolithography are inadequate in the construction of 3D microstructures. To solve this issue, researchers have proposed many strategies, among which 3D laser printing is becoming a prospective technique to create smart devices at the microscale because of its versatility, adjustability, and flexibility. Here, we review the recent progress in stimulus-responsive 3D microactuators fabricated with 3D laser printing depending on different stimuli. Then, an outlook of the design, fabrication, control, and applications of 3D laser-printed microactuators is propounded with the goal of providing a reference for related research.

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“… 170 Except for these artificial barriers, magnetic actuation of MagRobots on the uneven surface of biological tissue (i.e., ex vivo swine bladder) was investigated by Zhang’s group. 171 In addition to a rotating field, an oscillating magnetic field can also be adopted to actuate the translational movement of a surface walker. Under an oscillating field, microdimers consisting of Ni-SiO 2 magnetic Janus microspheres are able to roll on the solid surface after sedimentation treatment.…”

Section: Actuation and Mechanisms Of Magnetic Robotsmentioning

confidence: 99%

Magnetically Driven Micro and Nanorobots

et al. 2021

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Manipulation and navigation of micro and nanoswimmers in different fluid environments can be achieved by chemicals, external fields, or even motile cells. Many researchers have selected magnetic fields as the active external actuation source based on the advantageous features of this actuation strategy such as remote and spatiotemporal control, fuel-free, high degree of reconfigurability, programmability, recyclability, and versatility. This review introduces fundamental concepts and advantages of magnetic micro/nanorobots (termed here as “MagRobots”) as well as basic knowledge of magnetic fields and magnetic materials, setups for magnetic manipulation, magnetic field configurations, and symmetry-breaking strategies for effective movement. These concepts are discussed to describe the interactions between micro/nanorobots and magnetic fields. Actuation mechanisms of flagella-inspired MagRobots (i.e., corkscrew-like motion and traveling-wave locomotion/ciliary stroke motion) and surface walkers (i.e., surface-assisted motion), applications of magnetic fields in other propulsion approaches, and magnetic stimulation of micro/nanorobots beyond motion are provided followed by fabrication techniques for (quasi-)spherical, helical, flexible, wire-like, and biohybrid MagRobots. Applications of MagRobots in targeted drug/gene delivery, cell manipulation, minimally invasive surgery, biopsy, biofilm disruption/eradication, imaging-guided delivery/therapy/surgery, pollution removal for environmental remediation, and (bio)sensing are also reviewed. Finally, current challenges and future perspectives for the development of magnetically powered miniaturized motors are discussed.

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Disassembly and spreading of magnetic nanoparticle clusters on uneven surfaces

Cited by 48 publications

References 57 publications

Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery

Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery

Tethered and Untethered 3D Microactuators Fabricated by Two-Photon Polymerization: A Review

Magnetically Driven Micro and Nanorobots

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