“…However, clinicians should pay particular attention to patients with other predisposing factors for root resorption before orthodontic treatment, or when risk factors take place during treatment due to iatrogenic procedures and uncontrolled orthodontic mechanics. Thus, abnormal incisor root shape (narrow, pipette, pointed, or dilacerated roots), 1,3,27,34,49 idiopathic root resorption before orthodontic treatment, 83,84 unfavorable crown/root proportion at the beginning of treatment, 85 genetic predisposition to root resorption, 34,86 incisor intrusion mechanics mainly when combined with anterior retraction or lingual root torque, 7,35,80 and orthodontic forces exceeding biologic limits 87,88 should be considered with caution by clinicians, when a mini-implant is planned to anchor incisor retraction. The association of these risk factors can significantly intensify the biologic events linked to root resorption.…”