Disappearance of well-differentiated carcinoma of the prostate: effect of transurethral resection of the prostate, prostate-specific antigen, and prostate biopsy

Endrizzi, Joseph; Optenberg, Scott A.; Byers, Ruth; Thompson, Ian M.

doi:10.1016/s0090-4295(00)01108-0

Cited by 12 publications

(4 citation statements)

References 9 publications

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“…On analysis there was an equivalent substantial decrease in the number of well‐differentiated tumours (Gleason sum 2–4). The trend away from diagnosing prostate cancer with low Gleason score towards more moderately differentiated disease was documented in other studies assessing biopsies from the 1980s and early to mid 1990s [18,19], where there was a reduction of about half in numbers of Gleason sum 2–4 disease. This was attributed to fewer TURP biopsies (often detecting incidental prostate cancer), the increased use of PSA testing (with the resultant increased use of transrectal biopsies where the vast majority are ‘clinically and histologically significant’) and the knowledge that a significant proportion of tumours are ‘up‐staged’ after radical prostatectomy.…”

Section: Discussionmentioning

confidence: 70%

The increased rate of prostate specific antigen testing has not affected prostate cancer presentation in an inner city population in the UK

Mokete¹,

Shackley²,

Betts³

et al. 2006

BJU International

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Section: Discussionmentioning

confidence: 70%

The increased rate of prostate specific antigen testing has not affected prostate cancer presentation in an inner city population in the UK

Mokete¹,

Shackley²,

Betts³

et al. 2006

BJU International

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“…Therefore, undiagnosed prostate cancer is less likely to occur in a military control group than might occur in a civilian control group. While trends in the military may be more dramatic than the overall US population due to better access to care and more frequent PSA screening (introduced in 1987-1988) [1], this represents a large, fairly homogeneous cohort, with well-documented occupational codes. The primary objective of this report is to describe the prostate cancer risk in a younger and healthier subset of the US population with equal access to healthcare by investigating military service member data from September 1993 to September 2003 for demographic and other potential risk factors for prostate cancer hospitalization.…”

Section: Introductionmentioning

confidence: 99%

Racial differences in prostate cancer risk remain among US servicemen with equal access to care

et al. 2009

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“…2 This change could be due to either a decrease in the frequency of TURP or a decreased likelihood that any given TURP specimen would contain previously unrecognized adenocarcinoma in the era of contemporary PCa screening or both.…”

Section: Introductionmentioning

confidence: 99%

Probability of finding T1a and T1b (Incidental) prostate cancer during TURP has decreased in the PSA era

Jones

Follis

Johnson

2008

Prostate Cancer Prostatic Dis

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The purpose of this study is to assess the likelihood of detecting stage T1a and T1b cancer in transurethral prostatectomy specimens during the PSA era. Comparison was made of transurethral resection of prostate (TURP) cohorts in the pre-PSA era (1986)(1987) and the PSA era (1994)(1995)(1996)(1997)(1998)(1999)(2000), excluding patients with known PCa. A total of 228 men without a known history of prostate cancer underwent TURP during the pre-PSA era time frame and 501 underwent the procedure during the PSA era time frame. Malignancy diagnosed at the time of TURP decreased from 14.9 to 5.2% of patients in the pre-PSA and PSA eras, respectively. Stage T1a decreased from 4.4 to 2.4% and Stage T1b decreased from 10.5 to 2.8% of patients in the pre-PSA and PSA eras, respectively (Po0.001, Fisher's exact test). Prostate cancer newly identified during TURP has decreased significantly in the era of PSA screening in our study population, with the most significant drop being in clinically significant stage T1b. The decrease in TURP rates reduces the overall incidence of T1a/b cancer but cannot explain the lower risk of detecting previously unsuspected cancer at the time of any given TURP. Identification of many men with occult prostate cancer before TURP through screening and early detection is the most likely cause of this finding. These data suggest that men considering surgical or medical management of benign prostatic hyperplasia may be informed that it should be infrequent that men properly evaluated for prostate cancer will harbor clinically significant undetected malignancy.

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Disappearance of well-differentiated carcinoma of the prostate: effect of transurethral resection of the prostate, prostate-specific antigen, and prostate biopsy

Cited by 12 publications

References 9 publications

The increased rate of prostate specific antigen testing has not affected prostate cancer presentation in an inner city population in the UK

The increased rate of prostate specific antigen testing has not affected prostate cancer presentation in an inner city population in the UK

Racial differences in prostate cancer risk remain among US servicemen with equal access to care

Probability of finding T1a and T1b (Incidental) prostate cancer during TURP has decreased in the PSA era

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