Disappearance of Radioactive Serum Albumin from Joints in Rheumatoid Arthritis

Ahlström, Sune; Gedda, Per Olof; Hedberg, H.

doi:10.3109/rhe1.1956.2.issue-1-4.15

Cited by 51 publications

(8 citation statements)

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“…In contrast, the present studies compared the kinetics of TA in arthritic as well as normal joints. In rheumatoid arthritis and a variety of other conditions, the clearance of proteins from synovial fluid effusions is greater than from normal joints [20,21]. However, while NSAIDs, including TA [22,233, are strongly bound to albumin in plasma and synovial fluid, they appear to diffuse into and out of synovial fluid in the unbound form [10,24].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of tiaprofenic acid in normal rabbits and rabbits subjected to joint immobilisation

1993

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In a previous study, tiaprofenic acid (TA) was administered daily over a 30-day period at 5 and 10 mg/kg of body weight subcutaneously (s.c.) to animals with arthritis induced by immobilisation. The 10 mg/kg dose exacerbated the loss of proteoglycan from joint cartilage but the 5 mg/kg dose showed protective effects on articular cartilage. These results led us to investigate the concentration of TA achieved in synovial fluid of both the immobilised and non-immobilised rabbit joints after single s.c. doses of 5 or 10 mg/kg. The half-lives of elimination of TA from the synovial fluids of the immobilised joints were 1.27 and 1.07 h after the 5 and 10 mg doses, respectively, and 0.66 and 0.39 h in the non-immobilised contralateral joints. Clearances from synovial fluid to plasma were found to be 0.41 and 0.55 ml/h/kg from the immobilised joints after the 5 and 10 mg doses, respectively, and 0.11 and 0.25 ml/h/kg from the non-immobilised contralateral joints. The peak concentration of TA achieved in synovial fluid of immobilised knee joints after a single s.c. injection of 10 mg/kg was approximately two times greater than the concentrations achieved after administration of 5 mg/kg by the same route and two to six times greater than the levels achieved after oral administration of TA at 600 mg/day in humans.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of tiaprofenic acid in normal rabbits and rabbits subjected to joint immobilisation

1993

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“…Numerous studies employing indirect methods of dye or radioisotope washout from the synovial fluid have suggested that the circulation in the rheumatoid joint was greater than control levels (2)(3)(4). A method utilizing the washout of 'Xe from the joint has overcome the problems of recirculation and biologic activity of tracers and has shown strikingly increased local circulation in the rheumatoid joint (5).…”

Section: Introductionmentioning

confidence: 99%

A physiological approach to the assessment of disease activity in rheumatoid arthritis

Goetzl¹,

Falchuk²,

Zeiger³

et al. 1971

J. Clin. Invest.

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A B S T R A C T A method is described for assessing the in vivo oxygen consumption and lactate production rates of human knee joints. It is based on the rate of fall of Po, and the rate of rise in lactate concentration in an intra-articular saline pool after interruption of the circulation to the joint with an arterial tourniquet. Studies in 5 control patients with degenerative joint disease and 29 patients with rheumatoid arthritis showed a 2-to 3-fold higher mean oxygen uptake rate and a 10-to 12-fold higher mean lactate appearance rate in the saline in the rheumatoid joints with severe disease compared to the control joints. These metabolic variables correlated with tissue metabolic demand as estimated in synovial biopsies. '"Xe washout from the intra-articular space, which reflects joint circulatory flow, showed a 3-fold greater mean washout rate from the rheumatoid joints (48 studies) than control joints (7 studies) with extensive overlap between the two groups. '3Xe washout rate correlated with knee joint inflammation estimated both clinically and histologically. After synovectomy in four patients, the operated knee showed a greater fall in lactate production than the opposite knee in three of these patients. Neither knee joint oxygen uptake nor 1'Xe washout rate changed significantly. Intraarticular corticosteroid injection (eight patients) resulted in decreased lactate production and a decreased '"Xe washout rate in the injected knee and variable

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“…25,26,27,28,29,30,31,32,33 As the disease progresses, oxygen demand and consumption in the affected joint rises markedly, as does the production of carbon dioxide (CO 2 ). 34,35,36 In an attempt to meet this increased demand, the vascular network undergoes reorganization, adaptation, and redistribution.…”

Section: Dynamic Optical Imagingmentioning

confidence: 99%

Optical tomographic imaging of vascular and metabolic reactivity in rheumatoid joints

2005

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Our group has recently established that joints affected by Rheumatoid Arthritis (RA) can be distinguished from healthy joints through measurements of the scattering coefficient. We showed that a high scattering coefficient in the center of the joint is indicative of a joint with RA. While these results were encouraging, data to date still suffers from low sensitivity and specificity. Possibly higher specificities and sensitivities can be achieved if dynamic measurements of hemodynamic and metabolic processes in the synovium are considered. Using our dual-wavelength imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed initial dynamic imaging studies involving healthy human volunteers and patients affected by RA. These case studies seem to confirm our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints.

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Disappearance of Radioactive Serum Albumin from Joints in Rheumatoid Arthritis

Cited by 51 publications

References 1 publication

Pharmacokinetics of tiaprofenic acid in normal rabbits and rabbits subjected to joint immobilisation

Pharmacokinetics of tiaprofenic acid in normal rabbits and rabbits subjected to joint immobilisation

A physiological approach to the assessment of disease activity in rheumatoid arthritis

Optical tomographic imaging of vascular and metabolic reactivity in rheumatoid joints

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