Disappearance of exogenously administered human chorionic gonadotropin

Damewood, Marian D.; Shen, Wen; Zacur, Howard A.; Schlaff, William D.; Rock, John A.; Wallach, Edward E.

doi:10.1016/s0015-0282(16)60906-8

Cited by 160 publications

(60 citation statements)

References 8 publications

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“…hCG is the most commonly used hormonal trigger for egg maturation in clinical practice (31), stimulating the ovaries directly by binding to the LH receptor. hCG has LH-like activity that is far longer in duration than the endogenous physiological LH surge (38), and its effects are not subject to any negative feedback. As such, hCG can be associated with excessive ovarian stimulation that can lead to ovarian hyperstimulation syndrome (OHSS) (39).…”

Section: Discussionmentioning

confidence: 99%

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Jayasena¹,

Abbara²,

Comninos³

et al. 2014

J. Clin. Invest.

135

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METHODS.Following superovulation with recombinant follicle-stimulating hormone and administration of gonadotropinreleasing hormone antagonist to prevent premature ovulation, 53 women were administered a single subcutaneous injection of kisspeptin-54 (1.6 nmol/kg, n = 2; 3.2 nmol/kg, n = 3; 6.4 nmol/kg, n = 24; 12.8 nmol/kg, n = 24) to induce a luteinizing hormone surge and egg maturation. Eggs were retrieved transvaginally 36 hours after kisspeptin injection, assessed for maturation (primary outcome), and fertilized by intracytoplasmic sperm injection with subsequent transfer of one or two embryos. RESULTS.Egg maturation was observed in response to each tested dose of kisspeptin-54, and the mean number of mature eggs per patient generally increased in a dose-dependent manner. Fertilization of eggs and transfer of embryos to the uterus occurred in 92% (49/53) of kisspeptin-54-treated patients. Biochemical and clinical pregnancy rates were 40% (21/53) and 23% (12/53), respectively. CONCLUSION.This study demonstrates that a single injection of kisspeptin-54 can induce egg maturation in women with subfertility undergoing in vitro fertilization therapy. Subsequent fertilization of eggs matured following kisspeptin-54 administration and transfer of resulting embryos can lead to successful human pregnancy.

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Section: Discussionmentioning

confidence: 99%

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Jayasena¹,

Abbara²,

Comninos³

et al. 2014

J. Clin. Invest.

135

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“…Thus, the LH surge of the natural cycle is characterized by three phases with a total duration of 48 h [13] as compared to the GnRHa induced LH surge, consisting of only two phases with a duration of 28-32 h [12,13]. In contrast, a bolus of 10.000 IU hCG induces a LH-like activity still measurable in serum for 9-10 days due to the long biological half-life of hCG [14,15]. Bearing in mind these differences, the background of EFS after hCG triggering may not be the same as after GnRHa triggering.…”

Section: Introductionmentioning

confidence: 99%

Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

Castillo¹,

Garcia-Velasco

Humaıdan

2012

J Assist Reprod Genet

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“…However, whereas the physiological LH surge has a duration of approximately 48 h (Hoff et al 1985), the half-life of exogenous hCG is double that of the endogenous LH surge, with studies suggesting that hCG may persist in the circulation for up to 7 days (Damewood et al 1989). It is thought that the perseverance of hCG contributes to the development of OHSS, a potentially life-threatening condition that can affect 4% of all women undergoing IVF (Delvigne & Rozenberg 2002), but whose prevalence can increase by five-fold in at-risk populations (Wada et al 1993).…”

Section: Kisspeptin In In Vitro Fertilisationmentioning

confidence: 99%

Kisspeptin across the human lifespan:evidence from animal studies and beyond

Clarke

Dhillo

2016

Journal of Endocrinology

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Since its first description in 1996, the KISS1 gene and its peptide products, kisspeptins, have increasingly become recognised as key regulators of reproductive health. With kisspeptins acting as ligands for the kisspeptin receptor KISS1R (previously known as GPR54 or KPR54), recent work has consistently shown that administration of kisspeptin across a variety of species stimulates gonadotrophin release through influencing gonadotrophin-releasing hormone secretion. Evidence from both animal and human studies supports the finding that kisspeptins are crucial for ensuring healthy development, with knockout animal models, as well as proband genetic testing in human patients affected by abnormal pubertal development, corroborating the notion that a functional kisspeptin receptor is required for appropriate gonadotrophin secretion. Given the large body of evidence that exists surrounding the influence of kisspeptin in a variety of settings, this review summarises our physiological understanding of the role of these important peptides and their receptors, before proceeding to describe the varying role they play across the reproductive lifespan.

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Disappearance of exogenously administered human chorionic gonadotropin

Cited by 160 publications

References 8 publications

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

Kisspeptin across the human lifespan:evidence from animal studies and beyond

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