Disaccharide Intolerance and Mucoviscidosis

Nordio, S; Lamedica, G; Vignolo, L; Berio, A

doi:10.1016/s0140-6736(64)90597-5

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…Levels of maltase enzyme activity were reduced to approximately half of normal in our malnourished Brazilian infants. The loss of enzyme activity was similar to that reported in malnourished infants in other countries (27–47). The degree of villous atrophy was comparable to that reported in malnourished adults as well as children from other countries (48–67).…”

Section: Discussionsupporting

confidence: 87%

Contribution of Villous Atrophy to Reduced Intestinal Maltase in Infants With Malnutrition

Nichols,

Putman

et al. 2000

J. pediatr. gastroenterol. nutr.

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BackgroundIt has been known for many years that small intestinal maltase activities are reduced in malnourished infants and in other patients with villous atrophy. The recent availability of human maltase‐glucoamylase cDNA provides the opportunity to test the hypothesis that villous atrophy accounts for the reduced maltase enzyme activity in malnourished infants.MethodsMucosal biopsy specimens obtained for clinical evaluation of malnourished infants with poor responses to refeeding were examined by quantitative methods for enzyme activity and mRNA levels.ResultsMaltase activity and maltase‐glucoamylase mRNA were reduced (approximately 45% of normal). When maltase‐glucoamylase message was normalized to villin message, a structural protein expressed only in enterocytes, a preservation of maltase messages in surviving enterocytes was documented. The luminal glucose transporter–villin message was also preserved.ConclusionsThe loss of maltase‐glucoamylase message paralleled the reduction in villin message and degree of villous atrophy. The reduced maltase‐glucoamylase message also paralleled sucrase‐isomaltase message, previously found to be decreased in proportion to villous atrophy of malnourished infants. The data directly demonstrate, for the first time, that the terminal steps of starch 1‐4 starch digestion and sucrase‐isomaltase 1‐6 starch digestion are decreased in malnourished infants, secondary to villous atrophy. These data in prior and present reports suggest that mechanisms underlying the chronic villous atrophy of malnutrition should be a priority for investigations in malnourished infants with slower than expected weight gain during refeeding.

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Section: Discussionsupporting

confidence: 87%

Contribution of Villous Atrophy to Reduced Intestinal Maltase in Infants With Malnutrition

Nichols,

Putman

et al. 2000

J. pediatr. gastroenterol. nutr.

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“…Intestinal biopsy in cystic fibrosis usually shows normal mucosa (Rubin and Dobbins, 1965), but there have been reports of abnormality (Nordio, Lamedcia, Berio, and Vignolo, 1966;Jodl, Lojda and Simankova, 1972). It was reported there was 'primary' lactase deficiency in seven out of 28 cystic fibrosis patients (Antonowicz, Reddy, Khaw and Shwachman, 1968) and also one case where lactass lactase, maltase and sucrase levels were all low (Nordio, et aL, 1966).…”

Section: A Postulated Toxic Action Of the Gluten On The Small Intestimentioning

confidence: 99%

“…It was reported there was 'primary' lactase deficiency in seven out of 28 cystic fibrosis patients (Antonowicz, Reddy, Khaw and Shwachman, 1968) and also one case where lactass lactase, maltase and sucrase levels were all low (Nordio, et aL, 1966). In two cases of (Taylor and Sokol, 1973) dual occurrence of cystic fibrosis and coeliac disease, the enzymes, lactase, sucrase and maltase were still low after one year and nine months respectively on a gluten free diet.…”

Section: A Postulated Toxic Action Of the Gluten On The Small Intestimentioning

confidence: 99%