Disaccharidase deficiency in pediatric patients with celiac disease and intact villi

Mones, Richard L.; Yankah, Abena; Duelfer, Diane; Bustami, Rami; Mercer, Geraldine O

doi:10.3109/00365521.2011.619276

Cited by 18 publications

(17 citation statements)

References 28 publications

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“…Measurement of DS activities provides additional information at the time of diagnosis and during follow-up to assess the response to a GFD [19]. Furthermore, it has been shown that determining DS activities might aid the diagnosis of CD where milder histological changes are seen, including Marsh I and II [20] abnormalities in small intestinal biopsies [4, 10, 18]. …”

Section: Diagnostic Aspects Of Small Intestinal Disaccharidase Actmentioning

confidence: 99%

“…Milder biopsy changes that are limited to lymphocytic infiltration with or without crypt hyperplasia may require additional data in order to increase the certainty of a diagnosis of CD, as these histological changes are not exclusive to CD [4]. The diagnosis of CD may be enhanced by genotyping (HLA-DQ2 or HLA-DQ8); serological markers [4] and immunohistochemical staining of the γδ +ve intraepithelial lymphocytes found in patients with CD may also be used to confirm the diagnosis [24, 25].…”

Section: Diagnostic Aspects Of Small Intestinal Disaccharidase Actmentioning

confidence: 99%

“…Other conditions, including coeliac disease (CD), which result in small intestinal injury may cause reduction of disaccharidase (DS) activities. It has also been suggested that secondary DS deficiencies may possibly account for symptoms in patients with CD who have intact villi [4]. …”

Section: Introductionmentioning

confidence: 99%

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Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease

Šuligoj

Ciclitira

Božič

2017

Journal of Immunology Research

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Disaccharidases (DS) are brush border enzymes embedded in the microvillous membrane of small intestinal enterocytes. In untreated coeliac disease (CD), a general decrease of DS activities is seen. This manuscript reviews different aspects of DS activities in CD: their utility in the diagnosis and their application to in vitro toxicity testing. The latter has never been established in CD research. However, with the recent advances in small intestinal organoid techniques, DS might be employed as a biomarker for in vitro studies. This includes establishment of self-renewing epithelial cells raised from tissue, which express differentiation markers, including the brush border enzymes. Determining duodenal DS activities may provide additional information during the diagnostic workup of CD: (i) quantify the severity of the observed histological lesions, (ii) provide predictive values for the grade of mucosal villous atrophy, and (iii) aid diagnosing CD where minor histological changes are seen. DS can also provide additional information to assess the response to a gluten-free diet as marked increase of their activities occurs four weeks after commencing it. Various endogenous and exogenous factors affecting DS might also be relevant when considering investigating the role of DS in other conditions including noncoeliac gluten sensitivity and DS deficiencies.

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Section: Diagnostic Aspects Of Small Intestinal Disaccharidase Actmentioning

confidence: 99%

Section: Diagnostic Aspects Of Small Intestinal Disaccharidase Actmentioning

confidence: 99%

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Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease

Šuligoj

Ciclitira

Božič

2017

Journal of Immunology Research

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“…In patients with untreated celiac disease occur malnutrition, the mild forms may show malabsorption of iron, sideropenia and sideropenic anemia, not shown in nonCaucasians [39], metabolic bone disease due to malabsorption of calcium and vitamin D. [40] Parts is also lactose intolerance and deficiencies of other disaccharidases, even in patients with Marsh I histology [41], hypovitaminosis of vitamin B complex and vitamin C. Therefore, these symptoms should us lead to exclusion of celiac disease [40]. Severe forms of celiac disease with the destruction of the intestinal mucosa lead to severe proteinoenergetic malnutrition.…”

Section: Gluten Free Diet and Its Consequences Celiac Disease And Glmentioning

confidence: 99%

Nutrition in Celiac Disease

Kohout¹

2016

IJCD

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Nutrition plays a key role in patients with celiac disease. Gluten-free diet is main therapeutic option despite of new possibilities keeping the intestinal barrier, modulation of gut microbiome or extraction of gluten from the diet. The prevention of formation the autoimmune reaction against gluten in genetically predisposed patients is the addition of small amount of gluten-rich food during breastfeeding between 4th and 7th months of life. The possible prevention at a later age could include the keeping of gluten-free diet during stress-induced damage of intestinal barrier and/or the influence of gut microbiom using probiotics.Gluten-free diet become to be new phenomenon, new strategy for non-celiac population despite of absency of proven benefits for them. There are defined new clinical entities of gluten intolerance, especially non-celiac gluten sensitivity, but its differentiation from irritable bowel syndrome is very difficult. This issue will require further research.

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“…[59][60][61][62] Moreover, regulatory mechanisms pinpointing MLCK activation in various subcellular regions, i.e. TW and PAMR, for differential control of transcellular and paracellular barriers remain poorly understood.…”

Section: Terminal Web Contraction and Brush Border Fanningmentioning

confidence: 99%

Commensal bacterial internalization by epithelial cells: An alternative portal for gut leakiness

2015

Tissue Barriers

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Disaccharidase deficiency in pediatric patients with celiac disease and intact villi

Abstract: There is a profound deficiency of DS levels in pediatric patients with CD who have intact villi.

Cited by 18 publications

References 28 publications

Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease

Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease

Nutrition in Celiac Disease

Commensal bacterial internalization by epithelial cells: An alternative portal for gut leakiness

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