Abstract:7 infants, aged 5 weeks to 11 months, with clinically documented intolerance to cow’s milk protein, chronic diarrhea, and failure to thrive, underwent small intestinal (peroral, suction) biopsy before and after withdrawal of milk proteins. Mucosal specimens were examined by light microscopy and assayed for disaccharidase activities. In all patients, moderate to severe mucosal changes were present, associated with marked inflammation of the lamina propria and damage to the brushborder. Disaccharidase activities… Show more
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