Disability status and quality of life in multiple sclerosis: non-linearity of the Expanded Disability Status Scale (EDSS)

Twork, S.; Wiesmeth, Susanne; Spindler, Milena; Wirtz, Markus; Schipper, Sabine; Pöhlau, Dieter; Klewer, Jörg; Kügler, Joachim

doi:10.1186/1477-7525-8-55

Cited by 51 publications

(31 citation statements)

References 46 publications

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“…It seems that the largest impact on QoL comes from disease duration and EDSS-assessed level of disability. These dependencies, regardless of the QoL assessment methods used, are confirmed by the vast majority of researchers [32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 64%

“…Furthermore, Patti et al [34] showed that patients in Italy with EDSS results below 3.0 perform better on all SF-36 subscales in comparison with patients with higher disability levels. A German study by Twork et al [35] conducted with the MSQoL-54 questionnaire also proved that QoL decreases significantly with deteriorating mobility. Yamout et al [36], on the other hand, emphasise that not only physical disability causes QoL to fall, and point to other equally important factors such as lack of social support, depression, pain, cognitive disorders, and tiredness.…”

Section: Discussionmentioning

confidence: 91%

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Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Brola¹,

Sobolewski²,

Fudala³

et al. 2017

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Introduction: Comprehensive epidemiologic data for multiple sclerosis (MS) in Poland are limited. Aim of the research: To analyse patient-reported quality of life and selected clinical and socio-demographic factors of patients registered in the Świętokrzyskie Cohort of the Polish Registry of Multiple Sclerosis (RejSM). Material and methods: Participants were residents of Świętokrzyskie Province, and the data were collected between January 1 st 2014 and December 31 st 2015 by the RejSM web portal. After registration by doctors, the respondents assessed their quality of life individually using the Polish language versions of self-assessment questionnaires, the EuroQol (EQ-5D and EQ-VAS), and the Multiple Sclerosis Impact Scale (MSIS-29). Results: Of 1525 registered patients, 765 agreed to perform self-assessments of life quality and were included in the study. The mean degree of disability measured with the Expanded Disability Status Scale (EDSS) was 3.8 ±2.3. The mean EQ-5D index score was 0.78 ±0.28, and the mean EQ-VAS score was 65.6 ±23.8. Assessment score with MSIS-29 averaged 86.4 ±22.4 (64.2 ±19.6 for physical state and 24.7 ±7.8 for mental state). Only 34.7% of respondents were economically active. Lower quality of life was significantly associated with higher disability scores (p < 0.001), age over 40 years (p < 0.001), longer disease duration (p < 0.001), no access to therapy (p < 0.001), and unemployment (p = 0.002). No correlation was found between life quality and sex, course of disease, level of education, place of residence, or family status. Conclusions:The main factors decreasing life quality among patients in Świętokrzyskie Province are advanced disability, old age, long disease duration, and limited access to both employment and immunomodulatory treatment.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 91%

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Brola¹,

Sobolewski²,

Fudala³

et al. 2017

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“…[42][43][44][45] Patient physical disability has also been found to be associated with mental health challenges as well as reduced physical HRQOL. 5,16,42 Older adults with MS may be more isolated, be less able to leave their homes, and have less social support than younger individuals with MS.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Health-Related Quality of Life Among Older People with Multiple Sclerosis

Buhse

Banker²,

Clement³

2014

International Journal of MS Care

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Background: This study was conducted to determine which factors (clinical and demographic) are associated with mental and physical health-related quality of life (HRQOL) among people with multiple sclerosis (MS) aged 60 years and older. Methods: Data were collected at four MS centers on Long Island, New York, from a total of 211 patients. Three surveys were administered that collected demographic information and included validated questionnaires measuring quality of life (QOL), cognition, depression, and disability. Multivariate linear regression analyses examined the relationship between patient demographics and scores on standardized scales measuring mental and physical HRQOL (Multiple Sclerosis Quality of Life–54). Variables included in the regression models were selected on the basis of the Andersen Healthcare Utilization model. This framework encompasses the multiple influences on health status, including predisposing characteristics, enabling resources, need, and health behavior. Results: We found that mental HRQOL was negatively associated with having a high school education or less, risk of neurologic impairment, physical disability, and depression. No variables were positively associated with mental HRQOL. Physical HRQOL was negatively associated with risk of neurologic impairment, physical disability, depression, and the comorbidity of thyroid disease. However, patient employment and, surprisingly, being widowed were positively associated with physical HRQOL. These findings are consistent with those of similar studies among younger patients in which lower HRQOL was associated with increased disability, depression, risk of neurologic impairment, and lower levels of education. Conclusions: The findings that patient employment and being widowed were associated with better physical HRQOL suggest that older patients have the ability to adapt and adjust to the challenges of MS over time. Clinicians should regularly screen for HRQOL in older patients with MS.

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“…Higher scores indicate greater impact of walking gait disability on the quality of life of patients with MS [11][12][13] . The Expanded Disability Status Scale (EDSS) is an observer-rated (the neurologist) scale which grades disability due to MS in 20 steps on a continuum from 0 (normal neurological examination) to 10 (death due to MS) [14][15][16] . The MSIS-29/BR is a MS patient-rated measurement of quality of life.…”

Section: Methodsmentioning

confidence: 99%

Cross-cultural adaptation and validation of the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for the Brazilian population

Marangoni¹,

Pavan²,

Tilbery³

2012

Arq. Neuro-Psiquiatr.

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Gait impairment is reported by 85% of patients with multiple sclerosis (MS) as main complaint. In 2003, Hobart et al. developed a scale for walking known as The 12-item Multiple Sclerosis Walking Scale (MSWS-12), which combines the perspectives of patients with psychometric methods. OBJECTIVE: This study aimed to cross-culturally adapt and validate the MSWS-12 for the Brazilian population with MS. METHODS: This study included 116 individuals diagnosed with MS, in accordance with McDonald's criteria. The steps of the adaptation process included translation, back-translation, review by an expert committee and pretesting. A test and retest of MSWS-12/BR was made for validation, with comparison with another scale (MSIS-29/BR) and another test (T25FW). RESULTS: The Brazilian version of MSWS-12/BR was shown to be similar to the original. The results indicate that MSWS-12/BR is a reliable and reproducible scale. CONCLUSIONS: MSWS-12/BR has been adapted and validated, and it is a reliable tool for the Brazilian population.

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Disability status and quality of life in multiple sclerosis: non-linearity of the Expanded Disability Status Scale (EDSS)

Cited by 51 publications

References 46 publications

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Multiple sclerosis: patient-reported quality of life in the Świętokrzyskie Region

Factors Associated with Health-Related Quality of Life Among Older People with Multiple Sclerosis

Cross-cultural adaptation and validation of the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for the Brazilian population

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