Disability and functioning in primary and secondary hip osteoarthritis in Benin

Assogba, Todegnon; Natta, D.D. Niama; Kpadonou, Toussaint; Lawson, T. O. P. D; Mahaudens, Philippe; Detrembleur, Christine

doi:10.4102/ajod.v9i0.675

Cited by 2 publications

(1 citation statement)

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“…Primary osteoarthritis (OA), particularly knee OA, is the most common form of arthritis and is one of the leading causes of disability worldwide ( 1 , 2 ). The pathogenesis of OA is multifactorial and inter-related, involving structural degeneration and inflammation in multiple tissue types such as cartilage, bone, synovium, adipose depots, menisci, and ligaments ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis

Afzali,

Sykes,

Burton

et al. 2024

Ann Transl Med

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Background Several tissues contribute to the onset and advancement of knee osteoarthritis (OA). One tissue type that is worthy of closer evaluation, particularly in the context of sex, is the infrapatellar fat pad (IFP). We previously demonstrated that removal of the IFP had short-term beneficial effects for a cohort of male Dunkin-Hartley guinea pigs. The present project was designed to elucidate the influence of IFP removal in females of this OA-prone strain. It was hypothesized that resection of the IFP would reduce the development of OA in knees of a rodent model predisposed to the disease. Methods Female guinea pigs (n=16) were acquired at an age of 2.5 months. Surgical removal of the IFP and associated synovium complex (IFP/SC) was executed at 3 months of age. One knee had the IFP/SC resected; a comparable sham surgery was performed on the contralateral knee. All animals were subjected to voluntary enclosure monitoring and dynamic weight-bearing, as well as compulsory treadmill-based gait analysis monthly; baseline data was collected prior to surgery. Guinea pigs were euthanized at 7 months. Knees from eight animals were evaluated via histology, mRNA expression, and immunohistochemistry (IHC); knees from the remaining eight animals were allocated to microcomputed tomography (microCT), biomechanical analyses (whole joint testing and indentation relaxation testing), and atomic absorption spectroscopy (AAS). Results Fibrous connective tissue (FCT) replaced the IFP/SC. Mobility/gait data indicated that unilateral IFP/SC removal did not affect bilateral hindlimb movement. MicroCT demonstrated that osteophytes were not a significant feature of OA in this sex; however, trabecular thickness (TbTh) in medial femorae decreased in knees containing the FCT. Histopathology scores were predominantly influenced by changes in the lateral tibia, which demonstrated that histologic signs of OA were increased in knees containing the native IFP/SC versus those with the FCT. Similarly, indentation testing demonstrated higher instantaneous and equilibrium moduli in the lateral tibial articular cartilage of control knees with native IFPs. AAS of multiple tissue types associated with the knee revealed that zinc was the major trace element influenced by removal of the IFP/SC. Conclusions Our data suggest that the IFP/SC is a significant component driving knee OA in female guinea pigs and that resection of this tissue prior to disease has short-term benefits. Specifically, the formation of the FCT in place of the native tissue resulted in decreased cartilage-related OA changes, as demonstrated by reduced Osteoarthritis Research Society International (OARSI) histology scores, as well as changes in transcript, protein, and cartilage indentation analyses. Importantly, this model provides evidence that sex needs to be considered when investigating responses and associated mechanisms seen with this intervention.

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Section: Introductionmentioning

confidence: 99%

Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis

Afzali,

Sykes,

Burton

et al. 2024

Ann Transl Med

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A multidisciplinary assessment of disability in early medieval Culmen, Poland

Matczak,

Kozłowski,

Chudziak

2023

Spraw. Arch.

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This study bridges a gap between palaeopathology and the textual analysis, with the aim of investigating whichdiseases and pathological lesions could have been associated with disability in Early Mediaeval Culmen in Poland.We used palaeopathological methods to examine 661 skeletons, as well as reviewed Early Mediaeval hagiographiesand chronicles. The textual analysis revealed three types of disability: mobility difficulties, an abnormal posture, and blindness, which were also identified in the osteological materials from Culmen. Eight skeletons display lesions corresponding to Pott’s disease, poliomyelitis, leprosy, osteomyelitis, multiple myeloma, and amputation, which were identified as disabilities. The prevalence of disability depended on the age, with adults affected more frequently. This interdisciplinary study is the first to analyse people with disabilities on a population level, using textual sources and osteological materials from mediaeval Central Europe. The protocol forresearch on disability in archaeology presented by us may be applied to other archaeological contexts, also from sites outside Poland, from historical periods of time.

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Disability and functioning in primary and secondary hip osteoarthritis in Benin

Cited by 2 publications

References 41 publications

Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis

Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis

A multidisciplinary assessment of disability in early medieval Culmen, Poland

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