Disability-Adjusted Life Years Averted Versus Quality-Adjusted Life Years Gained: A Model Analysis for Breast Cancer Screening

Davidović, Maša; Zielonke, N.; Lansdorp–Vogelaar, Iris; Segnan, Nereo; Koning, Harry J. de; Heijnsdijk, Eveline A.M.

doi:10.1016/j.jval.2020.10.018

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 In addition, several studies have shown that using LYG, DALY averted, or QALY did not lead to opposite decisions. 58,59 In our study we also do not expect a major change in our outcomes when we would have used QALY instead of LYG because the ACER is far below the threshold of 3 times GDP per capita.…”

Section: Discussionmentioning

confidence: 84%

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis

Wang

Greuter

Zheng

et al. 2021

Int J Health Policy Manag

View full text Add to dashboard Cite

Background: To decrease the burden of breast cancer (BC), the Chinese government recently introduced biennial mammography screening for women aged 45-70 years. In this study, we assess the effectiveness and cost-effectiveness of implementing this programme in urban China using a micro-simulation model. Methods: The 'Simulation Model on radiation Risk and breast cancer Screening' (SiMRiSc) was applied, with parameters updated based on available data for the Chinese population. The base scenario was biennial mammography screening for women aged 45-70 years, and this was compared to a reference population with no screening. Seven alternative scenarios were then simulated by varying the screening intervals and participant ages. This analysis was conducted from a societal perspective. The discounted incremental cost-effectiveness ratio (ICER) was compared to a threshold of triple the gross domestic product (GDP) per life years gained (LYG), which was 30 785 USD/LYG. Univariate sensitivity analyses were conducted to evaluate model robustness. In addition, a budget impact analysis was performed by comparing biennial screening with no screening at a time horizon of 10 years. Results: Compared with no screening, the base scenario was cost-effective in urban China, giving a discounted average cost-effectiveness ratio (ACER) of 17 309 USD/LYG. The model was most sensitive to the cost of mammography per screen, followed by mean size of self-detected tumours, mammographic breast density and the cumulative lifetime risk of BC. The efficient frontier showed that at a threshold of 30 785 USD/LYG, the base scenario was the optimal scenario with a discounted ICER of 25 261 USD/LYG. Over 10 years, screening would incur a net cost of almost 38.1 million USD for a city with 1 million citizens. Conclusion:Compared to no screening, biennial mammography screening for women aged from 45-70 is cost-effective in urban China.

show abstract

Section: Discussionmentioning

confidence: 84%

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis

Wang

Greuter

Zheng

et al. 2021

Int J Health Policy Manag

View full text Add to dashboard Cite

show abstract

“…Cancer preventive interventions that were effective for this age cohort included; HPV cytology screening/triennial pap smear [94,95] and HPV vaccination in pre-adolescent girls for cervical cancer [94,96], biennial mammography in women above 40 years [90,95,97,98] and biennial clinical breast examination for breast cancer [90,97], colonoscopy every five years for colon cancer [95] and genomic screening of individuals at risk [53]. The effectiveness of annual mammography was found to be low due to the short interval of screening (Zehtab et al [98]).…”

Section: Plos Global Public Healthmentioning

confidence: 99%

High impact health service interventions for attainment of UHC in Africa: A systematic review

Karamagi

Berhane

Kidane

et al. 2022

PLOS Glob Public Health

View full text Add to dashboard Cite

African countries have prioritized the attainment of targets relating to Universal Health Coverage (UHC), Health Security (HSE) and Coverage of Health Determinants (CHD)to attain their health goals. Given resource constraints, it is important to prioritize implementation of health service interventions with the highest impact. This is important to be identified across age cohorts and public health functions of health promotion, disease prevention, diagnostics, curative, rehabilitative and palliative interventions. We therefore explored the published evidence on the effectiveness of existing health service interventions addressing the diseases and conditions of concern in the Africa Region, for each age cohort and the public health functions. Six public health and economic evaluation databases, reports and grey literature were searched. A total of 151 studies and 357 interventions were identified across different health program areas, public health functions and age cohorts. Of the studies, most were carried out in the African region (43.5%), on communicable diseases (50.6%), and non-communicable diseases (36.4%). Majority of interventions are domiciled in the health promotion, disease prevention and curative functions, covering all age cohorts though the elderly cohort was least represented. Neonatal and communicable conditions dominated disease burden in the early years of life and non-communicable conditions in the later years. A menu of health interventions that are most effective at averting disease and conditions of concern across life course in the African region is therefore consolidated. These represent a comprehensive evidence-based set of interventions for prioritization by decision makers to attain desired health goals. At a country level, we also identify principles for identifying priority interventions, being the targeting of higher implementation coverage of existing interventions, combining interventions across all the public health functions–not focusing on a few functions, provision of subsidies or free interventions and prioritizing early identification of high-risk populations and communities represent these principles.

show abstract

“…The effort of making improvements may be vital for patients with certain fatal diseases, such as some types of severe cancer [ 5 ]. The definition of a quality-adjusted life year (QALY) is a measure of human health outcomes regarding disease burden and is used to assess the value of medical interventions [ 6 ]. Additionally, a quality-adjusted life year measures how much additional time of life of reasonable quality a patient or person may gain due to treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, a quality-adjusted life year measures how much additional time of life of reasonable quality a patient or person may gain due to treatment. The QALY metric is essential in health economics, medical cost calculations, program evaluations, and insurance coverage determinations [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Global Mapping of Interventions to Improve Quality of Life of Patients with Cancer: A Protocol for Literature Mining and Meta-Analysis

Nguyen

et al. 2022

IJERPH

View full text Add to dashboard Cite

Cancer led to nearly 10 million deaths in 2020, as reported by the World Health Organization (WHO). Consequently, both biomedical therapeutics and psychological interventions have been implemented to decrease the burden of this non-communicable disease. However, the research conducted so far has only described some aspects of these interventions, which may increase the health-related quality of life of cancer patients. Therefore, a systematic review is necessary to depict an overall picture of the cancer interventions globally. Then, the impact of these interventions on the preference-based health-related quality of life of cancer patients may be synthesized. The protocol is developed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Web of Science database is used to retrieve the literature using four keyword terms: quality of life (QoL), cancer, interventions, and health utility. Then, we draw the global mapping diagram and conduct the meta-analysis for this research. Additionally, longitudinal measurements are used to estimate the changes in the health utility of patients during the interventions. Thus, this systematic review can provide insight into the impact of interventions on increasing the health-related quality of life (HRQL) of cancer patients.

show abstract

Disability-Adjusted Life Years Averted Versus Quality-Adjusted Life Years Gained: A Model Analysis for Breast Cancer Screening

Cited by 5 publications

References 22 publications

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis

High impact health service interventions for attainment of UHC in Africa: A systematic review

Global Mapping of Interventions to Improve Quality of Life of Patients with Cancer: A Protocol for Literature Mining and Meta-Analysis

Contact Info

Product

Resources

About