Dirofilaria immitis:Heartworm Infection Converts Histamine-Induced Constriction to Endothelium-Dependent Relaxation in Canine Pulmonary Artery

Kaiser, Lana; Williams, Jeffrey F.

doi:10.1006/expr.1998.4219

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Responses to vasoconstrictive agents such as methacholine, substance P, and A-23187 were suppressed in the pulmonary arteries of dogs with dirofilariasis compared with healthy controls, indicating that behavioral changes in endothelial cells, but not smooth muscle cells, contribute to vessel relaxation. It has also been shown that histamine, which causes vasoconstriction in healthy dogs, induced vasodilation in the arteries of dirofilariasis-infected dogs, which switched to vasoconstriction when arterial endothelial cells were eliminated (194). More recently, Kitoh et al (202) identified specific molecules in adult somatic antigens of D. immitis responsible for the shock induced by D. immitis products.…”

Section: Pathogenic Mechanisms Unrelated To the Immune Responsementioning

confidence: 99%

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

et al. 2012

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SUMMARY Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species ( Dirofilaria immitis and D. repens ) that have adapted to canine, feline, and human hosts with distinct biological and clinical implications. At the same time, both D. immitis and D. repens are themselves hosts to symbiotic bacteria of the genus Wolbachia , the study of which has resulted in a profound shift in the understanding of filarial biology, the mechanisms of the pathologies that they produce in their hosts, and issues related to dirofilariasis treatment. Moreover, because dirofilariasis is a vector-borne transmitted disease, their distribution and infection rates have undergone significant modifications influenced by global climate change. Despite advances in our knowledge of D. immitis and D. repens and the pathologies that they inflict on different hosts, there are still many unknown aspects of dirofilariasis. This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of Dirofilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human and animal infections.

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Section: Pathogenic Mechanisms Unrelated To the Immune Responsementioning

confidence: 99%

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

et al. 2012

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“…During this time, HW body components interact with vascular endothelial cells and smooth muscle cells. This interaction alters the capacity of the vascular wall to contract and relax, and thereby contributes to the pathogenic processes that lead to canine cardiopulmonary disease [4, 6, 17, 22]. …”

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confidence: 99%

Heartworm extract induces relaxation of isolated rat thoracic aorta

Kitoh

Nakamura

Kitagawa

et al. 2017

The Journal of Veterinary Medical Science

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Isolated rat thoracic aortic strips undergoing noradrenaline-induced contraction were treated with an adult heartworm (HW) crude extract and then examined for isometric changes in tension. HW extract caused relaxation of endothelium-intact strips, but not endothelium-denuded strips. This effect was inhibited by treatment with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) and could be reversed by additional treatment with L-arginine. However, HW extract at a high concentration caused slight relaxation of endothelium-denuded strips, and relaxation persisted after L-NAME treatment in endothelium intact-strips. These data suggested that the relaxation induced by HW extract was mainly endothelium-dependent, nitric oxide-mediated, but in part, also endothelium-independent. In addition, a bioassay using isolated rat thoracic aortas may be a useful tool for investigating vasoactive substances in the HW extract.

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“…MCs also contain large amount of histamine in their cytoplasmic granules [12]. Kaiser and Williams [7] reported that endothelium-dependent relaxation of pulmonary arteries depressed in dogs with Di, and they suggested that the arterial response was influenced by high serum histamine level, presumably derived from MCs. Although MCs were suspected to exert various roles, further studies are required to analyze their pathological and pathophysiological properties in pulmonary arteries of Diinfested dogs.…”

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confidence: 99%

Histopathological and Enzyme Histochemical Observations on Mast Cells in Pulmonary Arterial Lesion of Dogs with Dirofilaria immitis Infestation

Hidaka

Hagio

Horii

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Histopathological and enzyme histochemical observations were performed on mast cells in pulmonary arterial lesion of Dirofilaria immitis in dogs. The results showed that chymase-and tryptase-positive mast cells were diffusely present in the lesions, especially in the adventitia and proliferated intima. At 2 weeks after surgical worm transplantation, mast cells already appeared in the intima and media, and chymase-positive cells were dominant in the adventitia. Results of this study suggested a possibility that mast cells would be involved in the pathogenesis of pulmonary arterial lesion of dogs with Dirofilaria immitis infestation. KEY WORDS: canine pulmonary artery, Dirofilaria immitis, mast cell.

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Dirofilaria immitis:Heartworm Infection Converts Histamine-Induced Constriction to Endothelium-Dependent Relaxation in Canine Pulmonary Artery

Cited by 4 publications

References 21 publications

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

Heartworm extract induces relaxation of isolated rat thoracic aorta

Histopathological and Enzyme Histochemical Observations on Mast Cells in Pulmonary Arterial Lesion of Dogs with Dirofilaria immitis Infestation

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