Dirofilaria immitis: Depression of Endothelium-Dependent Relaxation of Canine Femoral Artery Seen in Vivo Does Not Persist in Vitro

Tithof, Patricia K.; Schwartz, Arthur G.; Mupanomunda, Maria; Schwartz, Naomi; Lamb, Victoria L.; Williams, J. F.; Kaiser, Lana

doi:10.1006/expr.1994.1075

Cited by 5 publications

(3 citation statements)

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“…Later studies provided evidence that products of the cyclooxygenase pathway in filariae, such as prostaglandin D2 (PGD2), induce the depression of endothelium-dependent relaxation at low, but not at high, acetylcholine concentrations (192). Changes observed for the arterial wall in vivo are short-lived and are completely dependent upon the presence of high concentrations of molecules released by female parasites (425). Endothelial cell-dependent relaxation was analyzed with and without inhibitors of NO synthase, cyclooxygenase, and guanylate cyclase.…”

Section: Pathogenic Mechanisms Unrelated To the Immune Responsementioning

confidence: 99%

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

et al. 2012

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SUMMARY Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species ( Dirofilaria immitis and D. repens ) that have adapted to canine, feline, and human hosts with distinct biological and clinical implications. At the same time, both D. immitis and D. repens are themselves hosts to symbiotic bacteria of the genus Wolbachia , the study of which has resulted in a profound shift in the understanding of filarial biology, the mechanisms of the pathologies that they produce in their hosts, and issues related to dirofilariasis treatment. Moreover, because dirofilariasis is a vector-borne transmitted disease, their distribution and infection rates have undergone significant modifications influenced by global climate change. Despite advances in our knowledge of D. immitis and D. repens and the pathologies that they inflict on different hosts, there are still many unknown aspects of dirofilariasis. This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of Dirofilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human and animal infections.

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Section: Pathogenic Mechanisms Unrelated To the Immune Responsementioning

confidence: 99%

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

et al. 2012

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“…During this time, HW body components interact with vascular endothelial cells and smooth muscle cells. This interaction alters the capacity of the vascular wall to contract and relax, and thereby contributes to the pathogenic processes that lead to canine cardiopulmonary disease [4, 6, 17, 22]. …”

mentioning

confidence: 99%

Heartworm extract induces relaxation of isolated rat thoracic aorta

Kitoh

Nakamura

Kitagawa

et al. 2017

The Journal of Veterinary Medical Science

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Isolated rat thoracic aortic strips undergoing noradrenaline-induced contraction were treated with an adult heartworm (HW) crude extract and then examined for isometric changes in tension. HW extract caused relaxation of endothelium-intact strips, but not endothelium-denuded strips. This effect was inhibited by treatment with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) and could be reversed by additional treatment with L-arginine. However, HW extract at a high concentration caused slight relaxation of endothelium-denuded strips, and relaxation persisted after L-NAME treatment in endothelium intact-strips. These data suggested that the relaxation induced by HW extract was mainly endothelium-dependent, nitric oxide-mediated, but in part, also endothelium-independent. In addition, a bioassay using isolated rat thoracic aortas may be a useful tool for investigating vasoactive substances in the HW extract.

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“…Mediante observaciones realizadas in vitro, Lamb et al (1993) demostraron que la capacidad de relajación del endotelio de la aorta de ratas disminuía cuando estaban en contacto con el suero procedente de perros infectados con D. immitis. No obstante, hay otros estudios que demuestran que la relajación de la arteria femoral de perros infectados por D. immitis no difiere de la de los no infectados, sugiriendo que los cambios observados in vitro son efímeros y para que se produzcan in vivo requieren de una continua exposición a factores circulantes de las filarias (Tithof et al, 1994).…”

Section: El Endotelio Vascular En Algunas Parasitosisunclassified

Mecanismos celulares y moleculares de la patología vascular de la dirofilariosis cardiopulmonar. El papel de las filarias y de los endosimbiontes del género Wolbachia

García¹

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Índice de contenidos 1.5.2.2. Test para la detección de anticuerpos anti-D. immitis…... 1.5.3. Enzimo inmuno ensayo (ELISA) para la detección de anticuerpos anti-Dirofilaria immitis y anti-Wolbachia………… 1.6. Criterios de clasificación de los hospedadores incluidos en el estudio… 1.7. ELISAs comerciales para la detección de los eicosanoides PGE 2 , TxB 2 y LTB 4 …………………………………………………...

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Dirofilaria immitis: Depression of Endothelium-Dependent Relaxation of Canine Femoral Artery Seen in Vivo Does Not Persist in Vitro

Cited by 5 publications

References 0 publications

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

Heartworm extract induces relaxation of isolated rat thoracic aorta

Mecanismos celulares y moleculares de la patología vascular de la dirofilariosis cardiopulmonar. El papel de las filarias y de los endosimbiontes del género Wolbachia

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