In molecular dynamics, several algorithms have been designed over the past few years to accelerate the sampling of the exit event from a metastable domain, that is to say the time spent and the exit point from the domain. Some of them are based on the fact that the exit event from a metastable region is well approximated by a Markov jump process. In this work, we present recent results on the exit event from a metastable region for the overdamped Langevin dynamics obtained in [22,23,57]. These results aim in particular at justifying the use of a Markov jump process parametrized by the Eyring-Kramers law to model the exit event from a metastable region.The objective of this note is to give motivations (Section 1) and outlines of the proofs (Section 2) of results recently obtained in [22,23,57]. These results justify the use of the Eyring-Kramers formulas together with a kinetic Monte Carlo model to model the exit event from a metastable state for the overdamped Langevin dynamics. Such results are particularly useful to justify algorithms and models which use such formulas to build reduced description of the overdamped Langevin dynamics.