Diretrizes da Sociedade Brasileira de Reumatologia para diagnóstico e tratamento da osteoporose em homens

Loures, Marco Antonio Rocha; Zerbini, Cristiano A F; Danowski, Jaime S.; Pereira, Rosa Maria Rodrigues; Moreira, Caio; Paula, Ana; Castro, Charlles Heldan de Moura; Szejnfeld, Vera Lúcia; Mendonça, Laura Maria Carvalho de; Radominiski, Sebastião C.; Bezerra, Mailze Campos; Simões, Ricardo; Bernardo, Wanderley Marques

doi:10.1016/j.rbr.2017.06.002

Cited by 14 publications

(4 citation statements)

References 140 publications

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“…This condition mainly affects women and the elderly, 2 and osteoporosis fractures are highly prevalent, thus representing an important public health problem. 3 The development of novel materials for bone growth is particularly important, as the World Health Organization has predicted an increase in the number of worldwide osteoporosis cases. However, to date, bioactive materials that can promote bone repair as a therapeutic method for treating osteoporosis are still missing.…”

Section: Introductionmentioning

confidence: 99%

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Oliveira¹,

Carvalho²,

Gusmão

et al. 2019

IJN

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BackgroundIt has been difficult to find bioactive compounds that can optimize bone repair therapy and adequate osseointegration for people with osteoporosis. The nano-hydroxyapatite (nHAp)/carbon nanotubes with graphene oxides, termed graphene nanoribbons (GNR) composites have emerged as promising materials/scaffolds for bone regeneration due to their bioactivity and osseointegration properties. Herein, we evaluated the action of nHAp/GNR composites (nHAp/GNR) to promote bone regeneration using an osteoporotic model.Materials and methodsFirst, three different nHAp/GNR (1, 2, and 3 wt% of GNR) were produced and characterized. For in vivo analyses, 36 Wistar rats (var. albinus, weighing 250–300 g, Comissão de Ética no Uso de Animais [CEUA] n.002/17) were used. Prior to implantation, osteoporosis was induced by oophorectomy in female rats. After 45 days, a tibial fracture was inflicted using a 3.0-mm Quest trephine drill. Then, the animals were separated into six sample groups at two different time periods of 21 and 45 days. The lesions were filled with 3 mg of one of the above samples using a curette. After 21 or 45 days of implantation, the animals were euthanized for analysis. Histological, biochemical, and radiographic analyses (DIGORA method) were performed. The data were evaluated through ANOVA, Tukey test, and Kolmogorov-Smirnov test with statistical significance at P<0.05.ResultsBoth nHAp and GNR exhibited osteoconductive activity. However, the nHAp/GNR exhibited regenerative activity proportional to their concentration, following the order of 3% >2% >1% wt.ConclusionTherefore, it can be inferred that all analyzed nanoparticles promoted bone regeneration in osteoporotic rats independent of analyzed time.

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Section: Introductionmentioning

confidence: 99%

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Oliveira¹,

Carvalho²,

Gusmão

et al. 2019

IJN

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“…The results indicated that 86% of patients evaluated in this study were in the yellow or red zone of the 10-year probability of a major fracture. This nding underscores the need for continuous evaluation and prophylaxis for osteoporosis in these patients, as recommended by the World Health Organization in protocols for bone densitometry indications [1,24,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Osteoimmunology in rheumatoid arthritis: a comparison between conventional therapies and biologics

Krüger

Silva

Teodoro

et al. 2023

Preprint

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Background Rheumatoid arthritis is an immune-mediated disease that affects the peripheral joints and is characterized by chronic systemic inflammation with systemic bone mineral density loss. Susceptibility to osteoporosis occurs due to systemic inflammation, as well as chronic corticosteroid use. The biologic and target-specific disease-modifying antirheumatic drugs (DMARDs) act effectively blocking systemic inflammation. We hypothesized that patients receiving biologic and target-specific DMARDs have higher bone mineral density, exhibit lower serum pro-inflammatory cytokine levels, and require lower corticosteroid doses than those receiving conventional therapy. Methods To test this hypothesis, we conducted a quantitative, descriptive, observational, cross-sectional and prospective clinical trial by collecting data from eligible patients. The participants were divided into three groups according to DMARD class (conventional synthetic, biologic, and target-specific DMARDs). The main inflammatory mediators of osteoporosis secondary to rheumatoid arthritis (tumor necrosis factor-α, interleukin-6), Disease Activity Score in 28 Joints, calculated using C-reactive protein, bone mineral density, bone turnover biomarker C-terminal telopeptide, and glucocorticoid dose were assessed in the three groups. Analysis of variance and Pearson product-moment correlation coefficient were used to compare the results among groups. Trial Registration Number - Certificate of Presentation for Ethical Consideration (CAAE): 46069821.4.0000.8667, 07/15/2021. Results TNF-α and IL-6 levels did not show significant correlation with any variable, such as DAS28-CRP, CTX, and bone mineral density of the lumbar spine, total femur, and femoral neck. The prednisone dose was significantly positively correlated with CTX and DAS28-CRP. Conclusion Among patients with Rheumatoid arthritis treatment with any disease-modifying antirheumatic drugs achieving low disease activity or remission decrease circulating cytokine levels and low bone resorption.

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“…1 These factors are considered to be determinants for protection against osteopenia, and later against osteoporosis, during adult life. 2 Among children and adolescents diagnosed with human immunodeficiency virus (HIV), lower bone mass concentrations and mineralization rates may occur due to impairments of adequate physical growth and consequent pubertal delay associated with HIV infection and prolonged use of antiretroviral therapy (ART). 3,4 In the growth process, regardless of sex, BMD and BMC concentrations do not develop linearly with chronological age.…”

Section: Introductionmentioning

confidence: 99%

Association between bone mineral density and content and physical growth parameters among children and adolescents diagnosed with HIV: a cross-sectional study

et al. 2022

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BACKGROUND: During childhood and adolescence, there are significant increases in bone mineral content (BMC) and bone mineral density (BMD). OBJECTIVE: To investigate physical growth parameters associated with BMD and BMC among children and adolescents diagnosed with human immunodeficiency virus (HIV). DESIGN AND SETTING: Cross-sectional study conducted in Florianópolis, Brazil, among 63 children and adolescents (aged 8-15 years) diagnosed with HIV. METHOD: BMD, BMC and fat percentage z score were evaluated using dual X-ray absorptiometry. Age/ height z score and body mass index (BMI)/age z score were obtained in accordance with international recommendations, and bone age was obtained through hand-wrist radiography. Sex, family income, information on HIV infection (T CD4+ lymphocyte count, viral load and type of antiretroviral therapy, moderate-vigorous physical activity and sedentary behavior) were used as adjustment variables in the analyses. Simple and multiple linear regression analyses were performed, with a significance level of P ≤ 0.05. RESULTS: Subtotal BMD (without the head region) was directly associated with bone age, BMI/age z score and fat percentage z score, even after adjusting for covariates. Subtotal BMC/height was directly associated with bone age, height/age z score, BMI/age z score and fat percentage z score, even after adjusting for covariates. CONCLUSION: Subtotal BMD and subtotal BMC/height were directly associated with physical growth indicators among children and adolescents diagnosed with HIV.

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Diretrizes da Sociedade Brasileira de Reumatologia para diagnóstico e tratamento da osteoporose em homens

Cited by 14 publications

References 140 publications

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

<p>High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model</p>

Osteoimmunology in rheumatoid arthritis: a comparison between conventional therapies and biologics

Association between bone mineral density and content and physical growth parameters among children and adolescents diagnosed with HIV: a cross-sectional study

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