Directly observed therapy and treatment adherence

Volmink, Jimmy; Matchaba, Patrice; Garner, Paul

doi:10.1016/s0140-6736(00)02124-3

Cited by 140 publications

(80 citation statements)

References 29 publications

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“…Similarly, patients who earn lower monthly income perceived quality of care to be better than patients who earned a higher income as the result showed. Our finding is similar previous findings which reported that TB patients who had no income were more satisfied with the TB care service than those who had savings [20]. Unlike our findings and those from other studies [21,22], the authors reported a positive relationship between service satisfaction and educational level.…”

Section: Discussionsupporting

confidence: 87%

Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria

Oladimeji¹,

Adeyinka²,

LehlogonoloMakola³

et al. 2018

Mycobacterium - Research and Development

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Background: Quality care is essential to the well-being and survival of people with multidrug-resistant tuberculosis (MDR-TB). The aim of this study is to explore how MDR-TB patients, who were voluntarily hospitalized, perceived care and treatment strategy and to assess the influence of psychosocial factors on their perception of care and treatment strategy in Nigeria. Methods: The study enrolled 98 MDR-TB patients on voluntary confinement in four MDR-TB hospitals in Nigeria. Patients' perceptions of quality of care and treatment strategy were evaluated with 28-item and 6-item instruments, respectively. Bivariate analysis was used to test for an association and multivariate analysis for factors that might contribute to the perceived quality of care. Results: Seventy-eight per cent (78%) of the participating patients perceived the quality of care to be good. Patients with better psychosocial well-being had five times higher odds to report good quality of care. Conclusion: The majority of MDR-TB patients perceived the quality of inpatient care to be good in Nigerian hospitals; however, their psychological

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Section: Discussionsupporting

confidence: 87%

Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria

Oladimeji¹,

Adeyinka²,

LehlogonoloMakola³

et al. 2018

Mycobacterium - Research and Development

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“…(7,8,(18)(19)(20) Some studies have shown that being in retreatment (due to noncompliance or recurrence) is strongly associated with noncompliance. This association was also found in the present study for the cases using SAT, (8,17) but not for those using DOTS. Alcoholism was the most highly prevalent comorbidity in the present study and was significantly associated with noncompliance among TB cases using SAT.…”

Section: Resultssupporting

confidence: 82%

“…Strategies such as DOTS or other possible adapted variations, depending on the local characteristics, particularities and conditions, should be developed and improved, based on the promising results of DOTS and other programs for the control of TB. (5,9,11,16,17) Most of the patients studied were from 21 to 45 years of age, which is considered to be the most economically productive age bracket, and males predominated, as did a low level of education, although none of these sociodemographic variables presented a significant association with noncompliance in either of the cohorts studied. However, being an unregistered worker, typically with a low salary and having had little education, was associated with noncompliance in the cohort using the SAT strategy, a finding that is in agreement with those of other studies.…”

Section: Resultsmentioning

confidence: 99%

“…In general, the lower noncompliance rate among patients using DOTS might be related to the more intimate, frequent and humanized contact between patients and the entire health care staff, resulting in a stronger bond between patients, their companions, families and the health care facility, as well as in better compliance with the therapeutic regimen and more favorable treatment outcomes, although the political administrative infrastructure as a whole also plays a role in improving the performance of the TCP. (8,11,14,17,19,25) Political, administrative, organizational and social changes, involving health care centers, the community, families and the media, are necessary. Ultimately, health care professionals should be trained and sensitized, by means of training courses and continuing education regarding DOTS.…”

Section: Discussionmentioning

confidence: 99%

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Abandono do tratamento de tuberculose utilizando-se as estratégias tratamento auto-administrado ou tratamento supervisionado no Programa Municipal de Carapicuíba, São Paulo, Brasil

Vieira¹,

Ribeiro

2008

J. bras. pneumol.

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Objective: To determine treatment noncompliance rates among patients participating in a municipal tuberculosis control program and to identify the variables related to noncompliance depending on the type of treatment strategy used. Methods: A longitudinal non-concurrent cohort study was carried out involving two cohorts of patients participating in the Tuberculosis Control Program of the city of Carapicuíba, Brazil. The first cohort comprised 173 patients with tuberculosis treated from January 1, 2003 to December 31, 2003 using self administration of treatment, and the second comprised 187 patients with tuberculosis treated from July 1, 2004 to June 30, 2005 using the directly observed therapy, short-course strategy. Results: Noncompliance rates decreased from 13.3% (self administration of treatment) to 5.9% (directly observed therapy, short-course), a significant difference (p < 0.05). For the self administration of treatment strategy, the variables significantly associated with treatment noncompliance were as follows: being an unregistered worker (relative risk [RR] = 3.06); retreatment (RR = 2.73); alcoholism (RR = 3.10); and no investigation of contacts (RR = 8.94). For the directly observed therapy, short-course strategy, no variables were significantly associated with noncompliance. Conclusion: The directly observed therapy, short-course strategy decreased noncompliance rates and produced better treatment outcomes, even when the risk factors for noncompliance were the same.

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“…Non-adherence is recognized as the most important obstacle to the control of Tb [10,[12][13][14][15] and that the abandonment DOTS entails: reduction in cure rates, increased relapses, [16] relapses, increased the patient's susceptibility to other infections [17] the possibility of stimulating the mechanisms of bacterial resistance and the continued spread of infection [18][19][20] lists the above strategies to improve adherence as a necessity [21].…”

Section: Introductionmentioning

confidence: 99%

Influence of Family System Characteristics on Adherence to Directly Observed Treatment, Short-Course (Dots) in Pulmonary Tuberculosis-A Cohort Study

Quiab¹

2014

J Mycobac Dis

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Objective: To evaluate the association of the characteristics of the family system in adherence observed treatment short in patients with pulmonary tuberculosis in three cities of the south-southeast of Mexico. Material and methods:Cases of pulmonary tuberculosis were studied, who started treatment at first-level units. The follow-up was 6 months or until the patient lost his grip, emigrated to another city, died, or decided not to continue the study. Intrafamilial relationships were assessed, family functioning (FACES III) and social network (DUKE UNC-11); adherence was assessed with test-Greene Morinsky. We calculated incidence of non-adherence and relative risk factors studied. Variables with significant differences in the bivariate analysis were subjected to the proportional hazards model of Cox.Results: Two hundred and thirty four patients were included; the total track joined 36,937 days, with a median of 175 days. Patients with dysfunctional family have RR=8.95 (95% CI=4.51-17.76, p<0.001) compared with those with functional family, and patients with non-functional network showed RR=2.22 (95% CI=1.13-4.35, p 0.002) compared with those with functional social network. In the Cox regression model adjusted for education, statistical significance was maintained for family functionality. Family functioning influences the cohorts studied in treatment adherence

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Directly observed therapy and treatment adherence

Cited by 140 publications

References 29 publications

Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria

Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria

Abandono do tratamento de tuberculose utilizando-se as estratégias tratamento auto-administrado ou tratamento supervisionado no Programa Municipal de Carapicuíba, São Paulo, Brasil

Influence of Family System Characteristics on Adherence to Directly Observed Treatment, Short-Course (Dots) in Pulmonary Tuberculosis-A Cohort Study

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