Directional x-ray dark-field imaging of strongly ordered systems

Jensen, Teis; Bech, Martin; Zanette, Irène; Weitkamp, Timm; Dávid, Christian; Deyhle, Hans; Rutishauser, Simon; Reznikova, E.; Mohr, Jürgen; Feidenhans’l, R.; Pfeiffer, Franz

doi:10.1103/physrevb.82.214103

Cited by 99 publications

(95 citation statements)

References 20 publications

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“…These techniques have evolved in different ways: X-ray tensor tomography has evolved from X-ray parallel perpendicular 50 mm 50 mm dark-field imaging using a grating interferometer [164], where ultra-small X-ray scattering is exploited [165]. The intensity modulations due to the rotation of the third grating [166,167] or of the sample [168,169] reveal the 2D orientation of the ultrastructure, and have been used to retrieve 2D ultrastructure organization of bone [170] or dentin [166]. By rotating the sample around two axes, and using an iterative reconstruction algorithm, it is possible to retrieve the 3D ultrastructure orientation [161].…”

Section: X-ray Scattering/diffraction Tensor Tomographymentioning

confidence: 99%

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Georgiadis

Müller

Schneider

2016

J. R. Soc. Interface.

113

100

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Bone's remarkable mechanical properties are a result of its hierarchical structure. The mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's building blocks at an ultrastructural level. The organization of bone's ultrastructure with respect to the orientation and arrangement of mineralized collagen fibrils has been the matter of numerous studies based on a variety of imaging techniques in the past decades. These techniques either exploit physical principles, such as polarization, diffraction or scattering to examine bone ultrastructure orientation and arrangement, or directly image the fibrils at the sub-micrometre scale. They make use of diverse probes such as visible light, X-rays and electrons at different scales, from centimetres down to nanometres. They allow imaging of bone sections or surfaces in two dimensions or investigating bone tissue truly in three dimensions, in vivo or ex vivo, and sometimes in combination with in situ mechanical experiments. The purpose of this review is to summarize and discuss this broad range of imaging techniques and the different modalities of their use, in order to discuss their advantages and limitations for the assessment of bone ultrastructure organization with respect to the orientation and arrangement of mineralized collagen fibrils.

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Section: X-ray Scattering/diffraction Tensor Tomographymentioning

confidence: 99%

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Georgiadis

Müller

Schneider

2016

J. R. Soc. Interface.

113

100

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“…This signal reveals structural information on the nanometer to hundreds-of-micrometers scale that is inaccessible from both the absorption and the phase-contrast image (28,29). Biomedical applications of dark-field contrast include bone imaging (30,31), calcifications in breast imaging (32), and tooth imaging (33).…”

mentioning

confidence: 99%

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede

Meinel²,

Bech

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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174

128

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In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.

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“…Through the combination of wave optics and MC, absorption, phase-shift, interference and scattering can be modelled within one framework. Recently a number of publications have been made that investigate the dark-field contrast formation mechanism Yashiro et al, 2010;Wang et al, 2009b;Jensen et al, 2010;Lynch et al, 2011;Chen et al, 2010) and different efforts to investigate GI using MC have already been published (Cong et al, 2012;Bartl et al, 2010), but, so far in the investigation of X-ray scattering, the particle and wave approach have been considered separately. However, our approach should provide new insights into the matter, since it combines MC with wave optics within the same framework.…”

Section: Introductionmentioning

confidence: 99%

Combining Monte Carlo methods with coherent wave optics for the simulation of phase-sensitive X-ray imaging

et al. 2014

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Phase-sensitive X-ray imaging shows a high sensitivity towards electron density variations, making it well suited for imaging of soft tissue matter. However, there are still open questions about the details of the image formation process. Here, a framework for numerical simulations of phase-sensitive X-ray imaging is presented, which takes both particle-and wave-like properties of X-rays into consideration. A split approach is presented where we combine a Monte Carlo method (MC) based sample part with a wave optics simulation based propagation part, leading to a framework that takes both particle-and wavelike properties into account. The framework can be adapted to different phasesensitive imaging methods and has been validated through comparisons with experiments for grating interferometry and propagation-based imaging. The validation of the framework shows that the combination of wave optics and MC has been successfully implemented and yields good agreement between measurements and simulations. This demonstrates that the physical processes relevant for developing a deeper understanding of scattering in the context of phase-sensitive imaging are modelled in a sufficiently accurate manner. The framework can be used for the simulation of phase-sensitive X-ray imaging, for instance for the simulation of grating interferometry or propagation-based imaging.

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Directional x-ray dark-field imaging of strongly ordered systems

Cited by 99 publications

References 20 publications

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Combining Monte Carlo methods with coherent wave optics for the simulation of phase-sensitive X-ray imaging

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