Directional mating and a rapid male population expansion in a hybrid Uruguayan population

Bertoni, Bernardo; Li, Jin; Chakraborty, Ranajit; Sans, Mónica

doi:10.1002/ajhb.20443

Cited by 20 publications

(26 citation statements)

References 46 publications

(44 reference statements)

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“…The maternal European contribution is 78%, whereas the maternal Basque contribution represents a lower percentage (see Table 1). These data also show that, as reported for other Uruguayan populations, there has been directional mating between non-European women and European men (Bertoni et al 2005;Bonilla et al 2004;Bravi et al 1997;Sans et al 2002Sans et al , 2006. Moreover, it reveals that matings between non-Basque women and Basque men have taken place, as shown by parish records (Barreto y Sans, 2000Sans et al 1996).…”

Section: Discussionsupporting

confidence: 65%

Mitochondrial DNA in Basque Descendants from the City of Trinidad, Uruguay: Uruguayan- or Basque-like Population?

et al. 2011

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Like other countries in the Americas, during its colonization Uruguay was the recipient of immigrants from several ethnic groups from Europe, as well as of enslaved Africans. After its independence in 1830, Basques were the first group of Europeans to arrive in the country. In this paper, we aim to contribute to the understanding of the process of integration of these migratory waves into the Uruguayan society. For that purpose, individuals of Basque origin from the city of Trinidad, Uruguay, were chosen to participate in this study. Particularly, we wanted to determine if Basque descendants in Uruguay remained relatively isolated or if they mixed with other ethnic groups. Mitochondrial DNA (mtDNA) of 60 self-identified Basque descendants, taken from a larger sample of subjects with Basque ancestors, was analyzed. The origin of mtDNA haplogroups was 77.8% European, 20.4% Amerindian, and 1.8% African, showing similar frequencies to other Uruguayan regions. Very few sequences showed a clear Basque origin, although other sources such as the Canary Islands are likely. Moreover, genetic distances clearly show that Basque descendants are genetically closer to other Uruguayan groups than to European populations, including Basques. It is possible to conclude that Basques and their descendants in the region of Trinidad did not remain isolated and that their marriage behavior was similar to that of other Uruguayan populations. However, to have a more accurate picture of the way Basques intermarried with other populations in Uruguay, new analyses are needed that take into account paternal lineages as well as biparental genetic markers.

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Section: Discussionsupporting

confidence: 65%

Mitochondrial DNA in Basque Descendants from the City of Trinidad, Uruguay: Uruguayan- or Basque-like Population?

et al. 2011

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“…The Uruguayan population has been considered as mainly European descent, with a negligible Native American or African contributions. However, based on serological and molecular markers, recent studies demonstrate that Native American and African had an important influence in the conformation of the present one [24–26]. …”

Section: Discussionmentioning

confidence: 99%

Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Lujambio

Sottolano

Luzardo

et al. 2014

International Journal of Nephrology

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Background. Estimation of glomerular filtration rate (eGFR) from biomarkers has evolved and multiple equations are available to estimate renal function at bedside. Methods. In a random sample of 119 Uruguayans (54.5% women; 56.2 years (mean)), we used Bland and Altman's method and Cohen's kappa statistic to assess concordance on a continuous or categorical (eGFR < 60 versus ≥60 mL/min/1.73 m2) scale between eGFRcys (reference) and eGFR derived from serum creatinine according to the Modification of Diet in Renal Disease (eGFRmdrd) or the Chronic Kidney Disease Epidemiology Collaboration equations (eGFRepi) or from both serum cystatin C and creatinine (eGFRmix). Results. In all participants, eGFRmdrd, eGFRepi, and eGFRmix were, respectively, 9.7, 11.5, and 5.6 mL/min/1.73 m2 higher (P < 0.0001) than eGFRcys. The prevalence of eGFR <60 mL/min/1.73 m2 was the highest for eGFRcys (21.8%), intermediate for eGFRmix (11.8%), and the lowest for eGFRmdrd (5.9%) and eGFRepi (3.4%). Using eGFRcys as reference, we found only fair agreement with the equations based on creatinine (Cohen's kappa statistic 0.15 to 0.23). Conclusion. Using different equations we reached clinically significant differences in the estimation of renal function. eGFRcys provides lower estimates, resulting in higher prevalence of eGFR <60 mL/min/1.73 m2.

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“…In particular, in southern South America the frequencies of haplogroups A and B decrease from north to south and the frequencies of haplogroups C and D increase Moraga et al 2000 (2) In addition to the studies on native populations, these genetic markers have allowed researchers to investigate the genetic composition of present-day American populations; it is possible to infer the substantial contribution of the Amerindian component to these populations, but the individuals have lost their ethnic identity because of dramatic historical, cultural, and social changes. Thus it has been possible to observe that, despite the centuries of European colonization and the disappearance of a large number of American ethnic groups, a substantial proportion of the original gene pool has been preserved in contemporary populations (Bertoni et al 2005;Bonilla et al 2004;Dipierri et al 1998;García and Demarchi 2006;Rocco et al 2002;Sans 2000;Wang et al 2008). These findings aid in the reconstruction of a past that was thought to be irretrievably lost until recently.…”

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confidence: 88%

Incidence and Distribution of Native American mtDNA Haplogroups in Central Argentina

García

Demarchi

2009

Human Biology

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We report the incidence and distribution of Native American mtDNA haplogroups in nine villages across the Sierras Centrales archeological area, located in central Argentina. The aims of the study were (1) to investigate the relative incidence of native maternal lineages, (2) to determine whether or not the homogeneous pattern observed in a previous study persists at this larger scale, and (3) to ascertain the genetic affinities between the studied population and other native populations of the Southern Cone of South America. Of the 310 individuals from whom DNA was extracted, 249 (80.3%) were assigned to one of the founding native American haplogroups. This finding confirms the persistence at high prevalence of native maternal lineages in the rural populations of central Argentina. The haplogroup distribution is homogeneous in the population samples from Córdoba province, with haplogroups C and D always found at the highest frequencies. The sample from San Luis province, Tilisarao, presents a different genetic pattern, with haplogroups A and B being the most frequent. Principal components analysis and SAMOVA at the regional level show that the Córdoba, Patagonia, and Tierra del Fuego populations cluster together, which suggests a common origin.

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Directional mating and a rapid male population expansion in a hybrid Uruguayan population

Cited by 20 publications

References 46 publications

Mitochondrial DNA in Basque Descendants from the City of Trinidad, Uruguay: Uruguayan- or Basque-like Population?

Mitochondrial DNA in Basque Descendants from the City of Trinidad, Uruguay: Uruguayan- or Basque-like Population?

Estimation of Glomerular Filtration Rate Based on Serum Cystatin C versus Creatinine in a Uruguayan Population

Incidence and Distribution of Native American mtDNA Haplogroups in Central Argentina

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