Directional Kinetics of Geographic Atrophy Progression in Age-Related Macular Degeneration with Foveal Sparing

Lindner, Moritz; Böker, Alexander; Mauschitz, Matthias M.; Göbel, Arno P.; Fimmers, Rolf; Brinkmann, Christian; Schmitz-Valckenberg, Steffen; Schmid, Matthias; Holz, Frank G.; Fleckenstein, Monika

doi:10.1016/j.ophtha.2015.03.027

Cited by 112 publications

(150 citation statements)

References 49 publications

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“…These preliminary results underscore the theory that CC breakdown precedes RPE and photoreceptor degeneration [7]. CC flow impairment at the margin of GA may also be a potential predictor of GA growth with regards to both growth direction and growth rate [49]. Possibly, the extent of CC flow impairment correlates with different hyperautofluorescent patterns at the margin of GA [50].…”

Section: Octa In Dry Amdsupporting

confidence: 56%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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Section: Octa In Dry Amdsupporting

confidence: 56%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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“…16,39 In accordance with the wide range of total lesion sizes, variable configurations of atrophic patches with sparing of the fovea were noted. Coalescence of multifocal patches and characteristic SD-OCT findings at the perilesional atrophic zone were observed as previously described, including hyporeflective wedge-shaped bands, migration of hyperreflective material, and changes in drusen height.…”

Section: Type 1: Spread Of Existing Paracentral Atrophy Toward the Foveamentioning

confidence: 64%

“…[7][8][9][10][11] Extensive research in the past has been focused on the manifestation and progression, that is, enlargement of GA. [12][13][14] Different subphenotypes and prognostic factors for disease progression have been identified, particularly along with the advent of high-resolution imaging modalities. 15,16 Recently, several large-scale clinical studies have been initiated and completed, aiming to halt or slow GA lesion enlargement. [17][18][19] Typically, the minimum total atrophic lesion size for inclusion in clinical studies in GA is currently 0.5 to 1.0 disc areas (1.25-2.5 mm 2 ).…”

mentioning

confidence: 99%

Multimodal Imaging Patterns for Development of Central Atrophy Secondary to Age-Related Macular Degeneration

Thiele

Pfau

Larsen

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate the development of central atrophy in eyes with age-related macular degeneration (AMD).METHODS. Six-year longitudinal multimodal retinal imaging data (MODIAMD study) from 98 eyes of 98 subjects with non-late-stage AMD in the study eye at baseline were analyzed for the presence of central atrophy at each annual follow-up visit. Development, manifestation, and further progression of complete retinal pigment epithelium and outer retinal atrophy (cRORA) by multimodal imaging data were compared with atrophy detection based on color fundus photography only.RESULTS. Seventeen study eyes with development of central cRORA within 6 years (cumulative rate: 17.4%) were identified based on multimodal imaging. In 10 (60%) of these eyes, presence of central manifest atrophy was initially not detectable by color fundus photography. In six (35%) eyes, central cRORA occurred by the spread of existing paracentral atrophy toward the fovea. Drusen-associated atrophy development was noted in eight eyes. In two eyes, atrophy development was associated with refractile deposits, while only pigmentary changes in absence of large drusen or refractile deposits were detectable before atrophy occurrence in one eye.CONCLUSIONS. The earlier and more precise detection of central cRORA by multimodal imaging as compared to atrophy detection solely based on color fundus photography allows for more accurate detection and identification of different pathways for atrophy development. In accordance with previous clinical and histopathologic reports, the results confirm that different precursor lesions may independently proceed to central cRORA in AMD.

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“…Together with a reduction of intra-and interreader variability, FAF imaging has become widely accepted for the detection of atrophy and its progression over time and is currently used in several large-scale, interventional clinical trials on geographic atrophy [51,52] . For the assessment of foveal sparing -which is challenging with blue-light FAF imaging, due to only minor differences in intensity between the macular pigment and atrophy -the use of corresponding near-infrared reflectance images has been proposed [53] .…”

Section: Definitions Of "Geographic Atrophy" In Natural History Studiesmentioning

confidence: 99%

The Journey of “Geographic Atrophy” through Past, Present, and Future

Schmitz-Valckenberg¹

2017

Ophthalmologica

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“Geographic atrophy” is a concise term that has been firmly established for the description of the end-stage manifestation of nonexudative age-related macular degeneration (AMD). “Geographic lesions” resembling sharply demarcated continents on a map have been originally described in the German literature in 1854 (landkartenartiger/inselförmiger Zungenfratt) for a manifestation later called “geographic tongue” in English. In 1970, Gass was the first to describe “geographic areas of atrophy” in “senile macular choroidal degeneration.” Within a decade, the disease itself was named “geographic atrophy.” Today, various meanings of the term are used in parallel both in research and in routine clinical care. Currently, we are on the verge of better understanding the different forms of atrophy development, manifestation, and progression in AMD, which will pave the way for a more rational approach to their nomenclature and classification.

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Directional Kinetics of Geographic Atrophy Progression in Age-Related Macular Degeneration with Foveal Sparing

Cited by 112 publications

References 49 publications

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Multimodal Imaging Patterns for Development of Central Atrophy Secondary to Age-Related Macular Degeneration

The Journey of “Geographic Atrophy” through Past, Present, and Future

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