Directional Fluid Transport across Organ–Blood Barriers: Physiology and Cell Biology

Caceres, Paulo; Benedicto, Ignacio; Lehmann, Guillermo L.; Rodríguez-Boulan, Enrique

doi:10.1101/cshperspect.a027847

Cited by 25 publications

(30 citation statements)

References 238 publications

(273 reference statements)

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“…The RPE tight junctions regulate the paracellular movement of solutes via size and charge selectivity ( Benedicto et al, 2017 ; Caceres et al, 2017 ; Naylor et al, 2019 ).Occludin and claudins determine the permeability and semi-selectivity of the TJs, and as such play critical roles in the oBRB ( Balda et al, 2000 ; Fields et al, 2019 ; Furuse et al, 1998 ; Günzel & Yu, 2013 ; Rosenthal et al, 2017 ). JAMs regulate TJ assembly and function by recruiting other proteins to the TJ and play an important role in the barrier property of TJs ( Balda & Matter, 2016 ; Orlova et al, 2006 ; Shin, Fogg & Margolis, 2006 ).…”

Section: Survey Methodologymentioning

confidence: 99%

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Zou

Shan

et al. 2020

PeerJ

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Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer composed of mitotically quiescent cells. Tight junctions and adherens junctions maintain the polarity of RPE cells, and are required for cellular functions. In proliferative vitreoretinopathy (PVR), upon retinal tear, RPE cells lose cell-cell contact, undergo epithelial-mesenchymal transition (EMT), and ultimately transform into myofibroblasts, leading to the formation of fibrocellular membranes on both surfaces of the detached retina and on the posterior hyaloids, which causes tractional retinal detachment. In PVR, RPE cells are crucial contributors, and multiple signaling pathways, including the SMAD-dependent pathway, Rho pathway, MAPK pathways, Jagged/Notch pathway, and the Wnt/β-catenin pathway are activated. These pathways mediate the EMT of RPE cells, which play a key role in the pathogenesis of PVR. This review summarizes the current body of knowledge on the polarized phenotype of RPE, the role of cell-cell contact, and the molecular mechanisms underlying the RPE EMT in PVR, emphasizing key insights into potential approaches to prevent PVR.

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Section: Survey Methodologymentioning

confidence: 99%

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Zou

Shan

et al. 2020

PeerJ

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“…[1][2][3][4] The blood-tissue barriers, for example, play a vital role in regulating drug transport from the capillaries to the targeted organs. 5 To exert functional activity, these capillaries typically consist of an endothelial cell layer and a basement membrane. More detailed, architectural, and organizational characteristics depend on organ-specific features giving rise to blood-tissue barriers variation from organ to organ.…”

Section: Introductionmentioning

confidence: 99%

Multiplexed blood–brain barrier organ-on-chip

et al. 2020

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“…In the formation of the oBRB, the fully mature RPE tight junctions (TJs) are formed, which have the role of limiting the paracellular movement of ions and water through the RPE monolayer and maintain the apical-basal distribution of the RPE transporters [57]. These features are crucial for maintaining retinal homeostasis since they allow for the formation of gradients that lead to directional fluid transport from the neural retina to the choroid [58]. Recent studies have shown that choroid endothelial cells (ECs) act as blood conduits, forming instructive niches for the differentiation, regeneration, and function of parenchymal cells, and may thus intervene in the regulation of ECs [59].…”

Section: Biological Signalling Process Of Retinamentioning

confidence: 99%

Retinal Drug Delivery: Rethinking Outcomes for the Efficient Replication of Retinal Behavior

et al. 2020

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The retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes that lead to retina degeneration. Knowledge and understanding of how our vision works are crucial to creating a hardware-adaptive computational model that can replicate retinal behavior. The neuronal system is nonlinear and very intricate. It is thus instrumental to have a clear view of the neurophysiological and neuroanatomic processes and to take into account the underlying principles that govern the process of hardware transformation to produce an appropriate model that can be mapped to a physical device. The mechanistic and integrated computational models have enormous potential toward helping to understand disease mechanisms and to explain the associations identified in large model-free data sets. The approach used is modulated and based on different models of drug administration, including the geometry of the eye. This work aimed to review the recently used mathematical models to map a directed retinal network.

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Directional Fluid Transport across Organ–Blood Barriers: Physiology and Cell Biology

Cited by 25 publications

References 238 publications

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Multiplexed blood–brain barrier organ-on-chip

Retinal Drug Delivery: Rethinking Outcomes for the Efficient Replication of Retinal Behavior

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