Directional dependent variation in mechanical properties of planar anisotropic porcine skin tissue

Lakhani, Piyush; Dwivedi, Krashn Kumar; Kumar, Navin

doi:10.1016/j.jmbbm.2020.103693

Cited by 26 publications

(30 citation statements)

References 42 publications

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“…Three-dimensional orientation of biomaterials is one of the goals of current tissue engineering, since most human tissues are characterized by a nonlinear and anisotropic mechanical behavior [44] due to the non-random distribution of its components, and this distribution is essential for its proper in vivo function. The use of FAH-MNPs-F could contribute to obtain MNPs-based bioartificial tissues with defined alignment with added value for use in regenerative medicine [45].…”

Section: In Vivo Evaluationmentioning

confidence: 99%

In vivo time-course biocompatibility assessment of biomagnetic nanoparticles-based biomaterials for tissue engineering applications

Campos

Bonhome-Espinosa

Carmona

et al. 2021

Materials Science and Engineering: C

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Section: In Vivo Evaluationmentioning

confidence: 99%

In vivo time-course biocompatibility assessment of biomagnetic nanoparticles-based biomaterials for tissue engineering applications

Campos

Bonhome-Espinosa

Carmona

et al. 2021

Materials Science and Engineering: C

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“…In practice, 𝐸 𝐿 is usually larger than 𝐸 𝑇 (Young's modulus along fibers is larger than that across), and the ratio of moduli is also usually limited by a factor 𝐸 𝐿 /𝐸 𝑇 < ~2 48,49 , i.e., 𝐸 𝐿 < ~7𝜇.…”

Section: Nearly Incompressible Transverse Isotropy (Niti) Of Skin's Elasticitymentioning

confidence: 99%

“…Fortunately, the anisotropy is not so strong for human skin 48,49 . Because the Rayleigh wave speed is a unique function of parameters 𝜇, 𝐺 and 𝛿, it can be used to reconstruct elastic properties in skin, i.e., skin's Young's moduli and Poisson's ratios outlined in Eqs.…”

Section: Wave Propagation In a Niti Mediummentioning

confidence: 99%

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Probing Elastic Anisotropy of Human Skin in Vivo With Light Using Non-Contact Acoustic Micro-Tapping OCE and Polarization-Sensitive OCT

Kirby

Tang

Liou

et al. 2021

Preprint

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Skin broadly protects the human body from undesired factors such as ultraviolet radiation and abrasion and helps conserve body temperature and hydration. Skin’s elasticity and its level of anisotropy are key to its aesthetics and function. Currently, however, treatment success is often speculative and subjective, and is rarely based on skin’s elastic properties because there is no fast and accurate non-contact method for imaging of skin’s elasticity. Here we report on a non-contact and non-invasive method to image and characterize skin’s elastic anisotropy. It combines acoustic micro-tapping optical coherence elastography (AmT-OCE) with a nearly incompressible transversely isotropic (NITI) model to quantify skin’s elastic moduli. In addition, skin sites were imaged with polarization sensitive optical coherence tomography (PS-OCT) to help define the fiber orientation. Forearm skin areas were investigated in five volunteers. Results clearly demonstrate elastic anisotropy of skin in all subjects. AmT-OCE has distinct advantage over competitive techniques because it provides objective, quantitative characterization of skin’s elasticity without contact, which opens the door for broad translation into clinical use. Finally, we demonstrate that a combination of multiple OCT modalities (structural OCT, OCT angiography, PS-OCT and AmT-OCE) may provide rich information about skin and can be used to characterize scaring.

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“…Therefore, understanding the mechanical behavior of skin at extensive stretching is essential. The bulge test method (Diab et al, 2020;Lakhani et al, 2020;Tonge et al, 2013) can apply load in all directions and overcome the limitation of small deformation but can only be used in ex vivo tests.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive in Vivo Quantification of Directional Dependent Variation in Mechanical Properties for Human Skin

Lakhani

Dwivedi

Parashar

et al. 2021

Front. Bioeng. Biotechnol.

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Skin is the body’s largest organ, and it shows non-linear and anisotropic behavior under the deformation. This behavior of the skin is due to the waviness and preferred orientation (in a particular direction) of collagen fibers. This preferred orientation of collagen fibers results in natural pre-tension and anisotropy of the skin. The knowledge of natural skin pre-tension and anisotropy is essential during incisions and surgery. The available suction-based devices quantify the anisotropy through the displacement field and cannot measure the stress-strain relation in particular directions. Therefore, in the current study, an in vivo full-field measurement suction apparatus was developed to measure the stress and strain of skin in all planar directions through a single experiment. First, this apparatus was tested on silicone substrates of known properties, and then it was used to test the skin of 12 human forearms. Further, to check the effect of hand stability on the measurements, the obtained results of the skin were compared with the results of a standard test performed in the same skin using a steady setup. The consistency between these two results confirms that the stability of the hand does not influence the measurements of skin properties. Furthermore, using the developed apparatus, the skin’s anisotropy and its relation with the Kraissl’s lines orientation was quantified by measuring the toe and linear moduli at an interval of one degree. The minimum and maximum values of the toe and linear moduli were 0.52 ± 0.09 and 0.59 ± 0.11 MPa, and 3.09 ± 0.47 and 5.52 ± 1.13 MPa, respectively. Also, the direction of maximum moduli was found almost similar to Kraissl’s lines’ orientation. These results confirm the contribution of skin pre-tension on the anisotropy of the skin. The present apparatus mimics the tissue expansion procedure, where observation of the test may be helpful in the selection of size and shape of the expander.

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Directional dependent variation in mechanical properties of planar anisotropic porcine skin tissue

Cited by 26 publications

References 42 publications

In vivo time-course biocompatibility assessment of biomagnetic nanoparticles-based biomaterials for tissue engineering applications

In vivo time-course biocompatibility assessment of biomagnetic nanoparticles-based biomaterials for tissue engineering applications

Probing Elastic Anisotropy of Human Skin in Vivo With Light Using Non-Contact Acoustic Micro-Tapping OCE and Polarization-Sensitive OCT

Non-Invasive in Vivo Quantification of Directional Dependent Variation in Mechanical Properties for Human Skin

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