Direction of Apt test modification: sensitivity and simplicity

Kim, Chang-Ryul; Park, Ile Kyu

doi:10.1016/j.jpeds.2014.11.049

Cited by 1 publication

(2 citation statements)

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“…Neonatal vitamin K deficiency is another common cause for hemorrhage; however, our infant received routine vitamin K injection shortly after birth. 9 While the Apt test 5 is useful in distinguishing maternal from fetal blood, limitations exist 15 , 16 ; it is only useful for determining if the sampled blood is predominantly fetal (>0%) hemoglobin or maternal (<10% fetal hemoglobin). Furthermore, tarry or melena specimens can give false positive results.…”

Section: Discussionmentioning

confidence: 99%

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Copious amount of bloody stool in a newborn shortly after birth

Shehab

Isalmovic

Williams

et al. 2021

SAGE Open Medical Case Reports

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Melena neonatorum is not uncommon; it presents as bloody stool in newborns and is caused by ingestion of maternal blood. This case presents an infant who had multiple episodes of copious amount of blood in his stool starting at 10 min of life, which raised multiple concerns requiring further investigation. The alkali denaturation test confirmed that the blood was maternal; however, due to the amount of bloody stool and the time required for the alkali denaturation test to result, further workups such as abdominal radiograph and hemoglobin/hematocrit were completed to ensure nothing was overlooked. Our infant remained clinically stable under the newborn nursery care, and did not require a higher level of care. He was discharged with his mother at 52 Hours of Life with a follow-up appointment the next day with the Primary Care Physician.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, tarry or melena specimens can give false positive results. 15 , 16 Modifications of the Apt test have since been made to increase the sensitivity and specificity of the test. 16 While this would be the fastest method to determine if the diagnosis for our infant is swallowed maternal blood, the test took 12 h to result.…”

Section: Discussionmentioning

confidence: 99%