Directing in Vitro Selection towards G‐quadruplex‐forming Aptamers to Inhibit HMGB1 Pathological Activity
Ettore Napolitano,
Andrea Criscuolo,
Claudia Riccardi
et al.
Abstract:In the search for novel, effective inhibitors of High‐Mobility Group Box1 (HMGB1) – a protein involved in various inflammatory and autoimmune diseases as well as in cancer – we herein discovered a set of anti‐HMGB1 G‐quadruplex(G4)‐forming aptamers by using an in vitro selection procedure applied to a doped library of guanine‐rich oligonucleotides. The selected DNA sequences were then studied in a pseudo‐physiological buffer mimicking the extracellular medium, where HMGB1 exerts its pathological activity, usin… Show more
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