Directing Group Assisted Copper‐Catalyzed C−H sulfanylation of Alkenyl Carbonyl Compounds with Disulfides

Abstract

A highly efficient and straightforward copper‐catalyzed sulfanylation of acrylamides with readily available disulfides has been developed. Through 8‐aminoquinoline‐assisted activation of the alkenyl C−H bond, a broad scope of (Z)‐alkenyl sulfides were constructed in moderate to excellent yields with good compatibility of functional groups. Moreover, the bidentate directing auxiliary promotes high regioselectivity of (Z)‐β‐alkenyl sulfides, and enables the excellent performance of copper catalyst in this transformation.