DIRECTEUR: transcriptome-based prediction of small molecules that replace transcription factors for direct cell conversion
Momoko Hamano,
Toru Nakamura,
Ryoku Ito
et al.
Abstract:Motivation
Direct reprogramming (DR) is a process that directly converts somatic cells to target cells. Although DR via small molecules is safer than using transcription factors (TFs) in terms of avoidance of tumorigenic risk, the determination of DR-inducing small molecules is challenging.
Results
Here we present a novel in silico method, DIRECTEUR, to predict small molecules that replace TFs for DR. We extracted DR-characte… Show more
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