Directed synthesis of nylon 5X key monomer cadaverine with alkaline metal modified Ru@FAU catalysts

Zhan-ling, MA; Qin, Shaojie; Yuan, Yifei; Xin, Zongwu; Luan, Likun; Zhang, Yanqiang; Huang, Yuhong

doi:10.1016/j.apcata.2023.119172

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…Particularly, the polymerization of cadaverine with dicarboxylic acids can produce exceptionally high-quality macromolecules, exemplified by the innovative nylon 5X. 7 Engineering microorganisms for cadaverine production has emerged as a promising substitute for conventional petrochemical processes. 8 Currently, there are primarily two approaches for synthesizing cadaverine using engineered microbes: (i) biotransformation and (ii) fermentation.…”

Section: Introductionmentioning

confidence: 99%

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Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

Liu,

Gao,

Song

et al. 2024

ACS Synth. Biol.

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Cadaverine is a critical C5 monomer for the production of polyamides. Pyridoxal 5′-phosphate (PLP), as a crucial cofactor for the key enzyme lysine decarboxylase in the cadaverine biosynthesis pathway, has seen a persistent shortage, leading to limitations in cadaverine production. To address this issue, a dual-pathway strategy was implemented, synergistically enhancing both endogenous and heterologous PLP synthesis modules and resulting in improved PLP synthesis. Subsequently, a growth-stage-dependent molecular switch was introduced to balance the precursor competition between PLP synthesis and cell growth. Additionally, a PLP sensor-based negative feedback circuit was constructed by integrating a newly identified PLPresponsive promoter P ygjH and an arabinose-regulated system, dynamically regulating the expression of the PLP synthetic genes and preventing excessive intracellular PLP accumulation. The optimal strain, L18, cultivated in the minimal medium AM1, demonstrated cadaverine production with a titer, yield, and productivity of 64.03 g/L, 0.23 g/g glucose, and 1.33 g/L/h, respectively. This represents the highest titer reported to date in engineered Escherichia coli by fed-batch fermentation in a minimal medium.

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Section: Introductionmentioning

confidence: 99%

“…In industrial settings, it stands as a backbone in the creation of polymers such as polyamides and polyurethanes as well as functions as a chelating agent and additive. Particularly, the polymerization of cadaverine with dicarboxylic acids can produce exceptionally high-quality macromolecules, exemplified by the innovative nylon 5X …”

Section: Introductionmentioning

confidence: 99%

Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

Liu,

Gao,

Song

et al. 2024

ACS Synth. Biol.

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“…1,5-pentanediamine (PDA) is the main raw material for the production of series bio-nylon 5X, which opens up a new green production method due to its valuable industrial applications [ 18 , 19 , 20 ]. With the increasing maturity of biotechnology for preparing PDA from biomass resources such as corn straw [ 21 , 22 , 23 ], the synthetic routes and small-scale industrial application of series nylon 5X have been preliminarily established [ 24 ]. Nylon 514, which is polymerized by the crystalline salts of 1,5-pentanediamine-tetradecanedioate (abbreviated to as PDA-TDA; see Figure 1 , C 19 H 40 N 2 O 4 , M.W.…”

Section: Introductionmentioning

confidence: 99%

Long-Chain Bio-Based Nylon 514 Salt: Crystal Structure, Phase Transformation, and Polymerization

Li,

Zhang,

Zhang

et al. 2024

Polymers

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Nylon 514 is one of the new long-chain bio-based nylon materials; its raw material, 1,5-pentanediamine (PDA), is prepared by biological techniques, using biomass as the raw material. The high-performance monomer of nylon 514, 1,5-pentanediamine-tetradecanedioate (PDA-TDA) salt, was obtained through efficient crystallization methods. Here, two crystal forms of PDA-TDA, anhydrous and dihydrate, were identified and studied in this paper. From the characterization data, their crystal structures and thermal behaviors were investigated. Lattice energy was calculated to gain further insight into the relationship between thermal stability and crystal structures. The contribution of hydrogen bonds and other intermolecular interactions to the crystal structure stability have been quantified according to detailed Hirshfeld and IRI analyses. Additionally, the transformation mechanism of the anhydrate and dihydrate was established through a series of well-designed stability experiments, in which the temperature and water activity play a significant role in the structural stability of crystalline forms. Eventually, we obtained nylon 514 products with good thermal stability and low absorption using stable dihydrate powders as monomers. The properties of nylon 514 products prepared by different polymerization methods were also compared.

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A novel Ru@GIS catalyst via interzeolite transformation for nylon 5X key monomer cadaverine synthesis

Ma,

Xin,

Huang

2024

Microporous and Mesoporous Materials

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Directed synthesis of nylon 5X key monomer cadaverine with alkaline metal modified Ru@FAU catalysts

Cited by 3 publications

References 56 publications

Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

Long-Chain Bio-Based Nylon 514 Salt: Crystal Structure, Phase Transformation, and Polymerization

A novel Ru@GIS catalyst via interzeolite transformation for nylon 5X key monomer cadaverine synthesis

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