Directed self-assembly software for single cell deposition

Abstract

Laser direct-write (LDW) bioprinting methods offer a diverse set of tools to design experiments, fabricate tissue constructs and cellular microenvironments all in a CAD/CAM matter. To date, we have just scratched the surface of the system’s potential. For LDW to be utilized to its maximum there are many distinct hardware and software components that must integrate and communicate seamlessly. In this perspective articles, we detail the development of novel graphical user interface (GUI) software to improve laser direct-write capability and functionality. The main modules in the control software correspond to cell transfer, microbead fabrication, and micromachining. Modules make the control of each of these features and the management of printing programs that utilize one or more features facile. The software also addresses problems related to construct scale-up, print speed, experimental conditions, and management of sensor data. The control software and possibilities for integrated sensor data are presented.

Machine learning boosts three-dimensional bioprinting

“…For example, parameters such as the speed set by the nozzle, the pressure, and the temperature used for extruding materials have a direct impact on cell activities. To secure the survival of the cells in the printed structure, it is usually necessary to mix the cells with the bioink before printing [ 9 ] . Bioink is used as a carrier in the field of 3D bioprinting.…”

IJB is on its way to Science Citation Index

“…Sklare et al . envision single cell bioprinting as enabled by their newly developed software[ 8 ]. Datta et al provide an overview of current bioprinting research landscape for osteochondral tissues[ 9 ].…”