Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling

Wu, Josephine Y.; Yeager, Keith; Tavakol, Daniel Naveed; Morsink, Margaretha; Wang, Bryan Z.; Bennett, David A.; Hung, Clark T.; Vunjak-Novakovic, Gordana

doi:10.1016/j.celrep.2023.112509

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Sonogenetic Application1

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2024

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Cited by 3 publications

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“…Furthermore, human-induced pluripotent stem cells can function as a cellular model for the optogenetic regulation of insulin secretion, implying prospective therapeutic applications in hyperglycemic disorders. 170 , 171 In considering future developments, it is crucial to acknowledge that optogenetic stimulation in deep tissue presents certain obstacles due to light absorption and scattering. Thus, sonogenetic stimulation may emerge as a more appropriate method for controlling diverse stem cell types, especially within deep tissue.…”

Section: Sonogenetic Applicationmentioning

confidence: 99%