Directed assembly of robust and biocompatible silk fibroin/hyaluronic acid composite hydrogels

Yan, Shuqin; Han, Guocong; Wang, Qiusheng; Zhang, Shangyong; You, Renchuan; Luo, Zuwei; Xu, Anchang; Li, Xiufang; Li, Mingzhong; Zhang, Qiang; Kaplan, David L.

doi:10.1016/j.compositesb.2019.107204

Cited by 61 publications

(39 citation statements)

References 38 publications

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“…Combining the properties of natural protein and polysaccharides can be a promising strategy to obtain bioactive materials with a controlled structure in the biomedical field [ 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. In silk fibroin/hyaluronic acid scaffolds, increasing hyaluronic acid content significantly enhanced the water binding capacity and flexibility [ 140 ]. The flexibility and water-absorbing quality of silk fibroin/hyaluronic acid hydrogels were improved due to the hydrophilicity of hyaluronic acid addition [ 140 ].…”

Section: Blendingmentioning

confidence: 99%

“…In silk fibroin/hyaluronic acid scaffolds, increasing hyaluronic acid content significantly enhanced the water binding capacity and flexibility [ 140 ]. The flexibility and water-absorbing quality of silk fibroin/hyaluronic acid hydrogels were improved due to the hydrophilicity of hyaluronic acid addition [ 140 ]. However, high amounts of hyaluronic acid in mixtures reduced the water stability [ 141 ].…”

Section: Blendingmentioning

confidence: 99%

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How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

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Section: Blendingmentioning

confidence: 99%

Section: Blendingmentioning

confidence: 99%

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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“…Silk fibroin hydrogels are formed from their transition from amorphous state to β-sheet conformations, which makes hydrogels strong but brittle. The combination of silk fibroin with GAG can be a strategy to improve and modulate the brittleness of produced hydrogels [114]. Silk fibroin has been combined with GAGs, mainly HA [115][116][117], with or without other polysaccharides such as alginate [118,119] or chitosan [120], for applications in skin wound healing [116,119], vascular growth factor delivery [121] and cartilage tissue [122].…”

Section: Silk Fibroinmentioning

confidence: 99%

“…Silk fibroin has been combined with GAGs, mainly HA [115][116][117], with or without other polysaccharides such as alginate [118,119] or chitosan [120], for applications in skin wound healing [116,119], vascular growth factor delivery [121] and cartilage tissue [122]. HA has been reported to improve mechanical properties of silk fibroin scaffolds partially by supporting silk fibroin transitions to β-sheet conformations [114,123], in a pH dependent complexation mechanism, and by leading to the formation of crystalline and non-crystalline phases [124].…”

Section: Silk Fibroinmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.

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“…Over decades, different crosslinking methods have been identified for the fabrication of chemically stable or degradable hydrogels for various applications [4][5][6]. Of particular interest, smart hydrogels have been extensively utilized for the sustained release of pharmaceutics with controlled pH [7][8][9], electric fields [10], osmosis [11], molecular structure [12,13], and temperature [14][15][16][17], regulating their swelling properties. In the meantime, numerous studies have been performed to improve the physical, mechanical, and biomedical properties of hydrogels, making them attractive for a wide range of applications [18,19].…”

Section: Introductionmentioning

confidence: 99%

Tuning Surface Morphology of Fluorescent Hydrogels Using a Vortex Fluidic Device

2020

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In recent decades, microfluidic techniques have been extensively used to advance hydrogel design and control the architectural features on the micro- and nanoscale. The major challenges with the microfluidic approach are clogging and limited architectural features: notably, the creation of the sphere, core-shell, and fibers. Implementation of batch production is almost impossible with the relatively lengthy time of production, which is another disadvantage. This minireview aims to introduce a new microfluidic platform, a vortex fluidic device (VFD), for one-step fabrication of hydrogels with different architectural features and properties. The application of a VFD in the fabrication of physically crosslinked hydrogels with different surface morphologies, the creation of fluorescent hydrogels with excellent photostability and fluorescence properties, and tuning of the structure–property relationship in hydrogels are discussed. We conceive, on the basis of this minireview, that future studies will provide new opportunities to develop hydrogel nanocomposites with superior properties for different biomedical and engineering applications.

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Directed assembly of robust and biocompatible silk fibroin/hyaluronic acid composite hydrogels

Cited by 61 publications

References 38 publications

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Tuning Surface Morphology of Fluorescent Hydrogels Using a Vortex Fluidic Device

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