Directed Assembly of Multisegment Au/Pt/Au Nanowires

Salem, Aliasger K.; Chen, Min; Hayden, Jessica; Leong, Kam W.; Searson, Peter C.

doi:10.1021/nl049462r

Cited by 74 publications

(56 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have shown that selective functionalization of multi-component nanorods can be achieved using metalspecific chemistries. For example, with Au-Ni bimetallic nanorods, thiol moities can be used to bind biotin (67,68), proteins (69) or cell targeting ligands (36) to the Au segment. Carboxylic acid moieties can be used to bind DNA to the Ni portion or can be used to block the surface of the central segment of tri-component nanowires so that only the tips are functionalized (36,68).…”

Section: Functionalizationmentioning

confidence: 99%

“…For example, with Au-Ni bimetallic nanorods, thiol moities can be used to bind biotin (67,68), proteins (69) or cell targeting ligands (36) to the Au segment. Carboxylic acid moieties can be used to bind DNA to the Ni portion or can be used to block the surface of the central segment of tri-component nanowires so that only the tips are functionalized (36,68). Such end-functionalized multi-component nanorods have potential for use in microswitch arrays or for building hierarchical structures (67,68).…”

Section: Functionalizationmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional Nanorods for Biomedical Applications

2007

Self Cite

View full text Add to dashboard Cite

Multifunctional nanorods have shown significant potential in a wide range of biomedical applications. Nanorods can be synthesized by a top down or bottom-up approach. The bottom-up approach commonly utilizes a template deposition methodology. A variety of metal segments can easily be incorporated into the nanorods. This permits high degrees of chemical and dimensional control. High aspect-ratio nanorods have a large surface area for functionalization. By varying the metal segments in the nanorods, spatial control over the binding of functional biomolecules that correspond with the unique surface chemistry of the metal segment can be achieved. Functionalized multicomponent nanorods are utilized in applications ranging from multiplexing, protein sensing, glucose sensing, imaging, biomolecule-associated nanocircuits, gene delivery and vaccinations.

show abstract

Section: Functionalizationmentioning

confidence: 99%

Section: Functionalizationmentioning

confidence: 99%

Multifunctional Nanorods for Biomedical Applications

2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…By reducing array spot size, less sample volume is needed because statistically, every analyte molecule will sample the entire capture surface at a greater rate (4). To fabricate nanoscale structures, biomolecules conjugated to nanowires can be patterned to direct their assembly (5,6). Moreover, nanoscale studies of protein and cell functions, which are often mediated by ligand-receptor binding, require a device capable of precisely delivering proteins and observing the response (7).…”

mentioning

confidence: 99%

Electric field-induced direct delivery of proteins by a nanofountain probe

Loh¹,

Ho²,

Rim³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

We report nanofabrication of protein dot and line patterns using a nanofountain atomic force microscopy probe (NFP). Biomolecules are continuously fed in solution through an integrated microfluidic system, and deposited directly onto a substrate. Deposition is controlled by application of an electric potential of appropriate sign and magnitude between the probe reservoir and substrate. Submicron dot and line molecular patterns were generated with resolution that depended on the magnitude of the applied voltage, dwell time, and writing speed. By using an energetic argument and a Kelvin condensation model, the quasi-equilibrium liquid-air interface at the probe tip was determined. The analysis revealed the origin of the need for electric fields in achieving protein transport to the substrate and confirmed experimental observations suggesting that pattern resolution is controlled by tip sharpness and not overall probe aperture. As such, the NFP combines the highresolution of dip-pen nanolithography with the efficient continuous liquid feeding of micropipettes while allowing scalability to 1-and 2D probe arrays for high throughput.arrays ͉ atomic force microscopy ͉ nanolithography ͉ patterning ͉ nanofabrication

show abstract

“…(Note that nanorods have also been known to assemble via a step polymerization process. [37] ) A precipitate forms, indicating the formation of insoluble assemblies of particles. TEM analysis of the precipitate confirms the presence of chains of NPs (Fig.…”

mentioning

confidence: 99%