Directed and enhanced neurite outgrowth following exogenous electrical stimulation on carbon nanotube-hydrogel composites

Imaninezhad, Mozhdeh; Pemberton, Kyle; Xu, Fenglian; Kalinowski, Kristin; Bera, R.; Zustiak, Silviya Petrova

doi:10.1088/1741-2552/aad65b

Cited by 57 publications

(51 citation statements)

References 82 publications

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“…Resilience to gap‐junction decoupling has been attributed to conductive scaffold‐mediated intercellular communication; however, nonconductive silica nanoparticles embedded in a scaffold can produce strong cardiomyocyte tissues that show synonymous resilience to conductive AuNPs scaffolds . This is a result of topography‐induced protein adhesion, a feature that often correlates with amount of dopant . The presence of nanotopographical cues has presented as more beneficial to cellular growth than conductivity.…”

Section: Discussion and Open Questions For The Use Of Conductive Tissmentioning

confidence: 99%

“…Imaninezhad et al sought to delineate the role of different hydrogel properties in conjunction with external electrical stimulation. The researchers employed polyacrylamide hydrogels and polyethylene glycol (PEG) hydrogels doped with MWCNT; stiffness and conductivity were compared on the resulting hydrogels.…”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

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Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

109

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Discussion and Open Questions For The Use Of Conductive Tissmentioning

confidence: 99%

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

109

102

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“…In addition to conducting polymers, hydrogels have been supplemented with metallic components to increase their conducting property. A micro-patterned silver nanowire-PEG hydrogel composite was used to provide both electrical and physical cues to facilitate directional and enhanced growth of neurites [99].…”

Section: Cells Encapsulated In Hydrogelsmentioning

confidence: 99%

Hydrogel systems and their role in neural tissue engineering

Madhusudanan

Raju

Shankarappa

2020

J. R. Soc. Interface.

129

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Neural tissue engineering (NTE) is a rapidly progressing field that promises to address several serious neurological conditions that are currently difficult to treat. Selecting the right scaffolding material to promote neural and non-neural cell differentiation as well as axonal growth is essential for the overall design strategy for NTE. Among the varieties of scaffolds, hydrogels have proved to be excellent candidates for culturing and differentiating cells of neural origin. Considering the intrinsic resistance of the nervous system against regeneration, hydrogels have been abundantly used in applications that involve the release of neurotrophic factors, antagonists of neural growth inhibitors and other neural growth-promoting agents. Recent developments in the field include the utilization of encapsulating hydrogels in neural cell therapy for providing localized trophic support and shielding neural cells from immune activity. In this review, we categorize and discuss the various hydrogel-based strategies that have been examined for neural-specific applications and also highlight their strengths and weaknesses. We also discuss future prospects and challenges ahead for the utilization of hydrogels in NTE.

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“…Conducting polymers and carbon materials are good options as fillers to provide hydrogels with electrical conductivity for bioelectronics. Zustiak and co‐workers used PA, PEG, and multi‐walled carbon nanotubes (MWCNT)‐PEG nanocomposite hydrogels of varying stiffness, resistivity, and MWCNT concentration for delivering a uniform electrical current . Figure shows an example of collagen‐PPy NPs hybrid hydrogel microfibers for in vitro electrical stimulation of PC12 cells.…”

Section: Hydrogels and Hydrophilic Polymersmentioning

confidence: 99%

“…Zustiak and co-workers used PA, PEG, and multi-walled carbon nanotubes (MWCNT)-PEG nanocomposite hydrogels of varying stiffness, resistivity, and MWCNT concentration for delivering a uniform electrical current. [67] Figure 2 shows an example of collagen-PPy NPs hybrid hydrogel microfibers for in vitro electrical stimulation of PC12 cells. The biomimetic 3D microstructure made from microfluidic chipenhanced cells aligning, and the high conductivity induced by PPy NPs further promoted neuronal functional expression.…”

Section: Electrically Conducting Hydrogelsmentioning

confidence: 99%

Soft and Ion‐Conducting Materials in Bioelectronics: From Conducting Polymers to Hydrogels

Jia

Rolandi

2020

Adv Healthcare Materials

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Bioelectronics devices that directly interface with cells and tissue have applications in neural and cardiac stimulation and recording, electroceuticals, and brain machine interfaces for prostheses. The interface between bioelectronic devices and biological tissue is inherently challenging due to the mismatch in both mechanical properties (hard vs soft) and charge carriers (electrons vs ions). In addition to conventional metals and silicon, new materials have bridged this interface, including conducting polymers, carbon‐based nanomaterials, as well as ion‐conducting polymers and hydrogels. This review provides an update on advances in soft bioelectronic materials for current and future therapeutic applications. Specifically, this review focuses on soft materials that can conduct both electrons and ions, and also deliver drugs and small molecules. The future opportunities and emerging challenges in the field are also highlighted.

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Directed and enhanced neurite outgrowth following exogenous electrical stimulation on carbon nanotube-hydrogel composites

Abstract: Our results indicate that nanocomposites, where carbon nanotubes have been added to hydrogel substrates, in combination with electrical stimulation provided improved conditions for neural growth and regeneration.

Cited by 57 publications

References 82 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Hydrogel systems and their role in neural tissue engineering

Soft and Ion‐Conducting Materials in Bioelectronics: From Conducting Polymers to Hydrogels

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