Direct-Writing Recorder of the Dose-Response Curves of the Airway to Methacholine

Takishima, Tamotsu; Hida, Wataru; Sasaki, Hidetada; Suzuki, Satoshi; Sasaki, Tsuyoshi

doi:10.1378/chest.80.5.600

Cited by 244 publications

(139 citation statements)

References 10 publications

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“…We did not include any patients with bronchial asthma or compare the airway hyperresponsiveness in CSA with that in bronchial asthma. The Dmin of patients with bronchial asthma in a previous report 28 was lower than that of patients with CSA in our study. This lower degree of airway hyperresponsiveness in patients with CSA than in those log Dmin of Methacholine (log units) 20 …”

Section: Discussioncontrasting

confidence: 82%

“…MCh (Sigma Chemical Co, St Louis, MO, USA) inhalation tests were performed using a device (Astograph TCK-6100H; Chest Co) that displayed a respiratory resistance (Rrs) dose -response curve measured by the forced oscillation method during tidal breathing with continuous inhalation of aerosolized MCh. This system was previously described by Takishima et al 28 and has been used in both clinical settings and clinical studies. 29,30 Briefly, it consists of an aerosol delivery system, a loudspeaker box system generating a constant amplitude sine wave pressure at 3 Hz and a system for automatically measuring Rrs from the mouth flow and mouth pressure.…”

Section: Circulation Journal Vol71 February 2007mentioning

confidence: 99%

“…Three indices 28 were used to evaluate airway responsiveness in each subject: (1) baseline value of Rrs (Rrs cont), defined as the mean value of Rrs obtained graphically during inhalation of saline for 1 min; (2) minimum dose (Dmin) of MCh, defined as the cumulative dose at the point at which respiratory conductance (Grs), obtained graphically as the reciprocal of Rrs, started to decrease linearly and calculated in terms of 1 unit =1 min inhalation of 1 mg/ml of MCh during tidal breathing; and (3) linear slope of the decreasing Grs (SGrs), defined as ∆Grs/∆t (in L·s -1 ·(cm H2O/min) -1 ·min -1 .…”

Section: Circulation Journal Vol71 February 2007mentioning

confidence: 99%

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Airway Hyperresponsiveness in Patients With Coronary Spastic Angina Relationship Between Coronary Spasticity and Airway Responsiveness

Shoji

Okayama²,

Uchida

et al. 2007

Circ J

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Background Several reports have suggested a possible link between bronchial asthma and coronary spasm, but the possibility of a relationship in coronary spastic angina (CSA) has not been clarified. Methods and ResultsAirway responsiveness to methacholine and coronary spasticity to acetylcholine were examined in 42 patients with CSA and 36 patients with chest pain syndrome (CP). Furthermore, 18 control subjects were examined and their airway responsiveness compared with that of the CSA and CP patients. The incidence of airway hyperresponsiveness was significantly higher in the CSA group (74%) than in the CP (19%) and control (17%) groups (p<0.0001). The geometric mean of the log minimum dose (Dmin), defined as the cumulative dose at the point at which respiratory conductance began to decrease, was significantly lower in the CSA group (0.75 log units) than in the CP (1.20 log units) and control (1.38 log units) groups (p=0.004). Conclusion These results demonstrate that acetylcholine-induced coronary spasticity is significantly related to methacholine-induced airway responsiveness in patients with CSA. A generalized hyperresponsiveness of the vascular and nonvascular smooth muscles, including that through cholinergic mechanisms, may exist in patients with CSA. (Circ J 2007; 71: 234 -241)

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Section: Discussioncontrasting

confidence: 82%

Section: Circulation Journal Vol71 February 2007mentioning

confidence: 99%

Section: Circulation Journal Vol71 February 2007mentioning

confidence: 99%

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Airway Hyperresponsiveness in Patients With Coronary Spastic Angina Relationship Between Coronary Spasticity and Airway Responsiveness

Shoji

Okayama²,

Uchida

et al. 2007

Circ J

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“…Airway responsiveness was then obtained by methacholine inhalation test (Astograph TCK-6000CV ; Chest, M.I. Inc. ; Tokyo, Japan) (18). Airway hyperresponsiveness was first measured by dose response curves of respiratory resistance (Rrs) and respiratory conductance (Grs ; Grs=1/Rrs) during cumulative inhalation of methacholine and was then assessed as the dose of methacholine producing a 35% fall in Grs (PD35-Grs).…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma

et al. 2010

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: Salivary pH is associated with esophageal acid reflux and neutralization of esophageal acid. In this study, we assessed the association between nocturnal decline of salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients with mild asthma (7 men and 2 women ; mean age 33.3 years ; mean % %predicted FEV1.0 89.4% %) and 10 healthy volunteers (6 men and 4 women ; mean age 31.2 years) using a pH indicator tape. The buffering capacity of saliva was defined as the median effective dose (ED50) for acidification of saliva with 0.01 N HCl, and airway responsiveness was defined as the dose of methacholine producing a 35% % fall in Grs (PD35-Grs). There was a significant correlation between the values obtained from the pH indicator tape and those obtained from the electrometric pH meter. Using the indicator tape for sequential monitoring, we observed a nocturnal fall (!pH) in salivary pH in all subjects. A significant correlation was found between airway hyperresponsiveness (PD35-Grs) and either !pH or ED50 in mildly asthmatic patients. Vagal reflux dysfunction might contribute to nocturnal salivary pH as well as to airway hyperresponsiveness in mild asthmatics. J. Med. Invest.

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“…Respiratory resistance (Rrs) during continuous inhalation of methacholine in stepwise increments was measured using a TCK 6100 Astograph (Chest Co., Tokyo, Japan) [13]. Methacholine was serially diluted two-fold with saline (in 10 dose steps from 25 mg .…”

Section: Measurement Of Airway Responsivenessmentioning

confidence: 99%

Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics

et al. 2000

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Leukotrienes (LTs) are pro-inflammatory mediators that contribute to the pathophysiological features of asthma. The relationship between the amounts of LTB 4 and LTC 4 produced by the leukocytes of asthmatic patients on the one hand and immunoglobulin E (IgE)-mediated allergy, asthma exacerbations and bronchial hyperresponsiveness was studied.Leukocytes were obtained from peripheral blood drawn from 29 atopic and 27 nonatopic asthmatics during exacerbations and clinically controlled periods, as well as from 20 control individuals. The leukocytes were stimulated with calcium ionophore A23187 to induce LTB 4 and LTC 4 production. Allergy was assessed by means of specific serum IgE or by positive skin tests, whereas bronchial hyperresponsiveness was measured by methacholine challenge.The leukocytes of the asthmatics generated significantly more LTB 4 (p<0.05) and LTC 4 (p<0.01) than those of controls. The leukocytes of patients with atopic asthma generated significantly more LTC 4 than those of patients with nonatopic asthma (p<0.01). Significantly more LTC 4 was produced by leukocytes obtained during exacerbations, than by those obtained during clinically controlled periods (p<0.01). In addition, there was a significant correlation between LTB 4 generation by leukocytes and the degree of bronchial hyperresponsiveness to methacholine (r=-0.792, p<0.0001).These results suggest that leukotriene C 4 production by leukocytes is associated with immunoglobulin E-mediated allergy and asthma exacerbations, and further that generation of leukotriene B 4 is closely related to bronchial hyperresponsiveness in patients with asthma. Eur Respir J 2000; 16: 504±508.

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Direct-Writing Recorder of the Dose-Response Curves of the Airway to Methacholine

Cited by 244 publications

References 10 publications

Airway Hyperresponsiveness in Patients With Coronary Spastic Angina Relationship Between Coronary Spasticity and Airway Responsiveness

Airway Hyperresponsiveness in Patients With Coronary Spastic Angina Relationship Between Coronary Spasticity and Airway Responsiveness

A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma

Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics

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