Direct visualization of the ouzo zone through aggregation-induced dye emission for the synthesis of highly monodispersed polymeric nanoparticles

Middha, Eshu; Manghnani, Purnima Naresh; Ng, Denise Z. L.; Chen, Huan; Khan, Saif A.; Liu, Bin

doi:10.1039/c9qm00020h

Cited by 25 publications

(29 citation statements)

References 39 publications

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“…(See details of the microfluidic approach in Scheme S1, Supporting information monodispersity [ 49 – 52 ].) As rapid mixing of solvent with anti-solvent (water) results in the instantaneous formation of nanodots due to the high level of supersaturation of the precursors [ 53 , 54 ], we performed the synthesis at a high flow rate of 16.5 mL min −1 for AIE-PS/polymer mixture solution with a mass ratio of 2 and Reynolds number of 350 (Fig. S1).…”

Section: Resultsmentioning

confidence: 99%

Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

Yaraki

Middha

et al. 2021

Nano-Micro Lett.

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Dual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.

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Section: Resultsmentioning

confidence: 99%

Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

Yaraki

Middha

et al. 2021

Nano-Micro Lett.

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“…32 Only a handful of reports demonstrated AIE NPs preparation involving a microfluidics approach. 31,[99][100][101] Often, coaxial microfluidic devices fabricated with glass capillaries are used to make the AIE NPs. [99][100][101] However, rapid and uniform mixing between the solvent in the channel is required to achieve a high-level nanoparticle uniformity with a smaller diameter.…”

Section: Application Of Microfluidics Technology In Aiegen Fabricationmentioning

confidence: 99%

Aggregation-Induced Fluorogens in Bio-Detection, Tumor Imaging, and Therapy: A Review

Balachandran

Jiang

2022

CCS Chem

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Aggregation-induced emission (AIE) produce strong, stable fluorescence upon aggregation, thus it is pushing a new frontier in bio-detection, cell imaging and other biomedical applications. In this review, we summarize the recent developments of AIEgens about design strategy, bio-detection, cell imaging, tumor imaging, vascular imaging and image-guided tumor therapy. We especially highlight a section on the microfluidic approach to synthesize AIE nanoparticles (NPs) and current challenges and promising prospects of AIE NPs.

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“…To address this issue, a microfluidic nanoprecipitation method was proposed for the mass production of AIE nanoparticles with excellent reproducibility and minimal batch‐to‐batch variation. [ 96,97 ] Liu and coworkers [ 96 ] reported an enhanced solvent displacement method to produce AIE nanoprobes with high monodispersity (PDI ≤ 0.1) and a tunable size (range between 25 and 200 nm) by modifying the miscibility between the solvent and antisolvent in the ouzo zone.…”

Section: Physical Properties Of Aie Nanoprobesmentioning

confidence: 99%

Aggregation‐Induced Emission Nanoprobes Working in the NIR‐II Region: From Material Design to Fluorescence Imaging and Phototherapy

Jiang

Fan

et al. 2021

Advanced Optical Materials

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In recent years, with increasing demands for in vivo fluorescence imaging and photodynamic therapy, light in the second near‐infrared window (NIR‐II; 1000–1700 nm) has attracted tremendous interest because it offers numerous merits, including deep penetration, minimal phototoxicity, diminished tissue autofluorescence, and reduced tissue absorption and scattering. Among the diverse types of nanoparticles, organic nanoprobes with aggregation‐induced emission (AIE) characteristics have emerged as a better option owing to their ultra‐brightness, excellent photostability, low cytotoxicity, and tailorable optical properties. Recent efforts in the AIE realm have revealed advancements in molecular design for long wavelength absorption and multiphoton excitation, which efficiently modulate the working optical region to the NIR‐II region. In this review, the current status of AIE nanoprobes in the NIR‐II window is summarized. Starting with molecular design strategies, recent efforts in fluorescence imaging and photodynamic therapy are then discussed. Finally, perspectives and challenges in this newly emerging field are given. This review hopes to encourage more innovative ideas in material design and biomedical applications for promoting AIE nanoprobes for future clinical translation.

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Direct visualization of the ouzo zone through aggregation-induced dye emission for the synthesis of highly monodispersed polymeric nanoparticles

Abstract: We report a new enhanced solvent displacement method for the synthesis of highly monodisperse nanoparticles with direct visualization of the ouzo zone.

Cited by 25 publications

References 39 publications

Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

Aggregation-Induced Fluorogens in Bio-Detection, Tumor Imaging, and Therapy: A Review

Aggregation‐Induced Emission Nanoprobes Working in the NIR‐II Region: From Material Design to Fluorescence Imaging and Phototherapy

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