Direct vascular effect of ropivacaine in femoral artery and vein of the dog

Abstract

A study was conducted to examine the direct vascular effect of ropivacaine, in comparison with the effect of bupivacaine and lidocaine. Changes in tension induced by ropivacaine (10(-5)-3 x 10(-3) mol l-1) and lidocaine (10(-5)-10(-2) mol l-1) were examined cumulatively in vascular rings of dog femoral artery and vein under basal tension, or in those which had been precontracted with phenylephrine submaximally in Krebs' bicarbonate solution at 37 degrees C aerated with 95% O2 and 5% CO2 (pH 7.4). The change in tension induced by 10(-2) mol l-1 ropivacaine was tested under basal tension in vascular rings bathed in HEPES buffer (pH 6.8). Ropivacaine induced greater constriction than bupivacaine at concentrations over 10(-3) mol l-1 in vascular rings under basal tension (P < 0.01). The maximal contraction was induced by ropivacaine at 10(-3) mol l-1, averaging 51.5 +/- 2.8% (n = 11) and 27.0 +/- 3.7% (n = 12) of the maximal contraction induced by epinephrine in the artery and vein, respectively, and the contractions induced by ropivacaine at 10(-2) mol l-1 were 16.3 +/- 2.0% (n = 11) and 5.5 +/- 1.1% (n = 9), respectively. Phenylephrine (10(-6) mol l-1)-precontracted artery was contracted significantly by ropivacaine at 3 x 10(-4) mol l-1 and 10(-3) mol l-1, and by bupivacaine at 3 x 10(-4) mol l-1, whereas the phenylephrine (10(-6) mol l-1)-precontracted vein was relaxed by these anesthetics. Lidocaine did not exert constricting effects.(ABSTRACT TRUNCATED AT 250 WORDS)

Intraocular Pressure and Quality of Blockade in Peribulbar Anesthesia Using Ropivacaine or Lidocaine with Adrenaline: A Double-Blind Randomized Study

“…There were no significant differences in the IOP levels between the groups, even though the IOP was decreased significantly below baseline values at 10 min in the ropivacaine group. It has been reported that the vasoconstrictive effect of ropivacaine leads to a decrease in the intraocular blood volume and that this might play a role in the observed decrease in the IOP (Nakamura et al 1993;Ishiyama et al 1997;Nociti et al 2001;Ozcan et al 2003). In addition, the IOP might have been decreased in the ropivacaine group because the diffusion of ropivacaine through the tissues may be faster than that of lidocaine.…”

Interactions médicamenteuses: les inhibiteurs de la lipoxygénase interfèrent avec la vasoconstriction provoquée par la ropivacaïne

“…[6][7][8][9] In contrast, local wound infiltration of ropivacaine results in a longer duration of action compared to bupivacaine, which has been attributed to a direct vasoconstrictive effect of ropivacaine on surrounding vessels. 10,11 In 2005, Yu et al 12 demonstrated the direct vasoconstrictive effect of ropivacaine on de-endothelialized rat aortic vasculature which Sung et al 3 reaffirm in this issue. Sung et al 3 demonstrated that clinically relevant concentrations of S-ropivacaine (Naropin TM ) at between 10 lM to 1 mM caused vasoconstriction of de-endothelialized rat aorta.…”

“…Ces concentrations, quoique bien plus élevées que les seuils cardiotoxiques et neurotoxiques pour le SNC , se trouvaient à proximité des nerfs pendant des injections périphériques, neuraxiales ou locales de ropivacaïne. Les actions vasomotrices directes de la ropivacaïne ont été étudiées dans différentes structures vasculaires, notamment les capillaires, 10 les veines fémorales, 11 les artères ombilicales, 13 les artères fémo-rales, 11 et l'aorte. 12,14,15 Certaines études n'ont pas montré d'effet de la ropivacaïne sur la détérioration de la vasorelaxation, 15 alors que d'autres ont observé des effets vasoconstricteurs directs.…”

“…These concentrations, though much above central neurotoxic and cardiotoxic thresholds, would be found in proximity of nerves during peripheral, neuraxial, or local injections of ropivacaine. The direct vasomotor actions of ropivacaine have been studied in different vascular structures including capillaries, 10 femoral veins, 11 umbilical arteries, 13 femoral arteries, 11 and the aorta. 12,14,15 Some of these studies showed no effect of ropivacaine on impairment of vasorelaxation 15 while others observed its direct vasoconstrictive effects.…”

Concentração plasmática de ropivacaína durante anestesia peridural lombar em crianças

“…Os resultados observados confirmam os obtidos por outros autores no que se refere às repercussões sobre as funções cardiovascular e neurológica, segundo os quais as duas drogas foram eficazes e não produziram alteração clínica significativa no sistema cardiovascular e neurológico 16 . No entanto, o estudo foi realizado em pacientes adultos e não foram dosadas as concentrações plasmáticas das duas drogas.…”