Direct Use of Copper-Containing Minerals in Goldberg Arylation of Amides

N,N′-Dimethylurea as an efficient ligand for the synthesis of pharma-relevant motifs through Chan–Lam cross-coupling strategy

“…83,84 Primary amides do not undergo N-arylation readily and there are few easily adoptable methods for arylation. They have been previously reported to be N-arylated with diazonium salts, 85 Goldberg arylating agentaryl halides, [86][87][88][89][90][91] aryltrimethoxysilane, 92 iodoferrocene, 93 and hetero(aryl) electrophiles. 94,95 However, very few studies have been executed with boronic acid and its derivatives.…”