Direct Urine Ammonium Measurement In Metabolic Acidosis: Time To Move On

Jena, Narendra Nath; Jayaraman, Srinivasan; Menezes, Ritesh G.; Thirumalaikolundusubramanian, Ponniah

doi:10.1017/s1481803500003444

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…One of the main advantages that supports the use of automated systems in clinical laboratories is the analytes' quantification in a more simple, fast, accurate, economical and standardized way compared to manual techniques, which are more complex, timeconsuming and sometimes risky (8)(9)(10). In the case of Nessler method, previously used in our laboratory, potassium tetraiodomercuriate (II) (K 2 HgI 4 ) and potassium hydroxide (KOH) solutions were highly toxic by inhalation and skin contact and have a risk of cumulative effects, severe burns and negative environmental impact (12), entailing an additional hazard for laboratory staff.…”

Section: Discussionmentioning

confidence: 99%

“…To overcome these limitations, several authors have implemented the urinary ammonium determination in biochemistry autoanalyzer's, by using methods originally developed to quantify plasma ammonium concentrations, with satisfactory results (6,(8)(9)(10). In this study, we evaluated the urinary ammonium measurement in single urine samples by adapting an automated method for plasma ammonium quantification.…”

Section: Introductionmentioning

confidence: 99%

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Automation and performance evaluation of an adapted method for the determination of urinary ammonium

Ros¹,

Bailo²,

González³

et al. 2022

Med Lab

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Automation and performance evaluation of an adapted method for the determination of urinary ammonium

Ros¹,

Bailo²,

González³

et al. 2022

Med Lab

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“…Alteplase was associated with spurious hyperphosphatemia in one child [15] and eight adults [16,17]. On the other hand, heparin caused pseudohyperphosphatemia in each one child [14] and one adult [18].…”

Section: • Other Medicinal Productsmentioning

confidence: 94%

Interferences in the measurement of circulating phosphate: a literature review

Molinaris

Bianchetti

Milani

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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AbstractBackgroundInorganic phosphate in blood is currently determined by the reaction with molybdate. This report aims at reviewing conditions underlying spuriously altered levels of circulating inorganic phosphate.ContentA systematic search of the Excerpta Medica, the National Library Database and the Web of Science database was conducted without language restriction from the earliest publication date available through January 31, 2020.SummaryFor the analysis, 80 reports published in English (n = 77), French (n = 1), German (n = 1) and Spanish (n = 1) were retained. Well-documented pseudohyperphosphatemia was observed in individuals exposed to liposomal amphotericin, in patients affected by a gammopathy, in patients with hyperlipidemia and in patients with hyperbilirubinemia. An unexplained elevated inorganic phosphate level sometimes provided a clue to the diagnosis of a gammopathy. Well-documented cases of pseudohypophosphatemia were observed in patients on large amounts of intravenous mannitol. Finally, pseudohypophosphatemia was occasionally observed on treatment with liposomal amphotericin and in patients with a gammopathy.OutlookIn order to avoid unnecessary testing and treatment, the phenomenon of spuriously altered inorganic phosphate should be recognized. An unexplained hyperphosphatemia may provide a clue to the diagnosis of a gammopathy or a severe hyperlipidemia.

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Direct Urine Ammonium Measurement In Metabolic Acidosis: Time To Move On

Cited by 2 publications

References 6 publications

Automation and performance evaluation of an adapted method for the determination of urinary ammonium

Automation and performance evaluation of an adapted method for the determination of urinary ammonium

Interferences in the measurement of circulating phosphate: a literature review

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