Direct Synthesis of Benzoselenophene and Benzothiophene Derivatives from 1,1-Diarylethenes and Biaryls by Chalcogen Cation-Mediated Successive Bond Formation

Iwamoto, Hiroki; Kojima, Yuki; Nishimura, Kazutoshi; Yasui, Kosuke; Hirano, Koji

doi:10.1021/acs.orglett.3c04033

Org. Lett.

2024

DOI: 10.1021/acs.orglett.3c04033

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Direct Synthesis of Benzoselenophene and Benzothiophene Derivatives from 1,1-Diarylethenes and Biaryls by Chalcogen Cation-Mediated Successive Bond Formation

Hiroki Iwamoto,

Yuki Kojima,

Kazutoshi Nishimura

et al.

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An Overview of the Pharmacological Activities and Synthesis of Benzothiophene Derivatives

Pathak,

Singh,

Sharma

et al. 2024

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One important class of organic compounds having many uses, especially in medical chemistry, is benzothiophene and its derivatives. This review examines the biological activity of benzothiophene derivatives and summarizes the synthetic methods used in their production. The effectiveness of several synthetic pathways, such as cyclization techniques, functional group modifications, and reactions catalyzed by transition metals, in gaining access to benzothiophene scaffolds has been examined. Additionally, a broad spectrum of therapeutic domains, such as antiinflammatory, antibacterial, antidiabetic, anticancer, antimicrobial, anti-leishmanial, antifungal, antimalarial, and antitubercular activities, are covered by the pharmacological activities that are being explored. The synthesis and pharmacological potential of benzothiophene derivatives are well-explained in this thorough review, which opens up new options for medicinal chemistry and drug discovery study. Overall, this study is a useful resource for scientists working on drug development and discovery as it sheds light on the pharmacological potential of benzothiophene derivatives. This review includes the synthesis and bioactivities of the years 2002-2024. The goal of this review is to compile the existing information on benzothiophene derivatives and provide guidance for future research and development as well as insights into their possible medicinal uses.

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An Overview of the Pharmacological Activities and Synthesis of Benzothiophene Derivatives

Pathak,

Singh,

Sharma

et al. 2024

View full text Add to dashboard Cite

show abstract

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Direct Synthesis of Benzoselenophene and Benzothiophene Derivatives from 1,1-Diarylethenes and Biaryls by Chalcogen Cation-Mediated Successive Bond Formation

Cited by 1 publication

References 36 publications

An Overview of the Pharmacological Activities and Synthesis of Benzothiophene Derivatives

An Overview of the Pharmacological Activities and Synthesis of Benzothiophene Derivatives

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