Direct synthesis of 2-oxazolines from carboxylic acids using 2-chloro-4,6-dimethoxy-1,3,5-triazine under mild conditions

Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives

“…There are numerous methods of forming 2-oxazoline ring, especially the microwave-assisted synthesis in which different amino alcohols, N-(β-hydroxy) amides yielded differently substituted 2-oxazolines. [15][16][17] Recently, it has been reported on the one-pot synthesis of 2-hydroxyphenyl-4-methyloxazoline-4-carboxamide substructures, found also in some natural cytotoxic agents such as brasilibactin A. 18 Because of that, the other part of the present research was directed towards finding a suitable way for the microwave-catalyzed synthesis of some new 2-(2-hydroxyphenyl)-4-substituted derivatives of 2-oxazoline.…”

An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation

“…Due to their pharmaceutical and synthetic material applications, the preparation of 2-oxazoline derivatives has been holding the fascination of many synthetic chemists all these years. The reaction of carboxylic acids [12][13][14][15][16][17] or acid derivatives like ester [18][19][20][21][22] with 2-aminoethanol is the most common method for the synthesis of oxazolines. In addition, other substrates such as imidate hydrochlorides [23], N-(2-hydroxyethyl) amides [24][25][26][27][28][29], ortho esters [30], imino ether hydrochlorides [31], aldehydes [32][33][34][35][36][37] and nitriles [38][39][40][41][42][43][44][45][46] have been used to prepare the oxazolines.…”

A convenient preparation of novel benzophenone derivatives

“…[32][33][34][35] Excellent review articles were published in 1949 and in 1971 covering the preparation, reactions and applications of oxazoline. 30,31 Substituted 2-oxazolines have been widely investigated for pharmaceutical uses.…”