Direct Surface Functionalization of Cellulose Nanocrystals with Hyperbranched Polymers through the Anionic Polymerization for pH-Responsive Intracellular Drug Delivery

Wan, Weimin; Ouyang, Hui; Long, Wei; Yan, Weigang; He, Mingzhen; Huang, Hongye; Yang, Shilin; Zhang, Xiaoyong; Feng, Yulin; Wei, Yen

doi:10.1021/acssuschemeng.9b05231

Cited by 44 publications

(18 citation statements)

References 53 publications

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“…For instance, Wan et al developed a new approach to prepare hyperbranched polymers-functionalized CNCs through direct anionic polymerization utilizing glycidol as the monomer and surface hydroxyl groups of CNCs as initiator. The peripheral end functional groups of the modified CNCs were then converted to hydrazide groups, which could be used for loading anticancer drugs, such as epirubicin, through the formation of hydrazone bonds with pH-responsiveness (Wan et al, 2019). The authors suggested that epirubicin could be released from CNCs-based carriers with pH-responsive behavior and that the obtained drug-containing complexes could preserve their anticancer capability.…”

Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

Nanocellulose: From Fundamentals to Advanced Applications

et al. 2020

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Over the past few years, nanocellulose (NC), cellulose in the form of nanostructures, has been proved to be one of the most prominent green materials of modern times. NC materials have gained growing interests owing to their attractive and excellent characteristics such as abundance, high aspect ratio, better mechanical properties, renewability, and biocompatibility. The abundant hydroxyl functional groups allow a wide range of functionalizations via chemical reactions, leading to developing various materials with tunable features. In this review, recent advances in the preparation, modification, and emerging application of nanocellulose, especially cellulose nanocrystals (CNCs), are described and discussed based on the analysis of the latest investigations (particularly for the reports of the past 3 years). We start with a concise background of cellulose, its structural organization as well as the nomenclature of cellulose nanomaterials for beginners in this field. Then, different experimental procedures for the production of nanocelluloses, their properties, and functionalization approaches were elaborated. Furthermore, a number of recent and emerging uses of nanocellulose in nanocomposites, Pickering emulsifiers, wood adhesives, wastewater treatment, as well as in new evolving biomedical applications are presented. Finally, the challenges and opportunities of NC-based emerging materials are discussed.

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Section: Nanocellulose For Biomedical Applicationsmentioning

confidence: 99%

Nanocellulose: From Fundamentals to Advanced Applications

et al. 2020

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“…Among them, nanocellulose is a renewable, biodegradable, and natural biopolymer that has considerable application prospects in drug delivery systems. For instance, Wan et al [333] designed an effective method for designing hyperbranched polymerfunctionalized CNCs without direct anionic polymerization (Figure 22a). The end groups of the resulting functionalized CNC surface are further converted to acylhydrazide groups, which can be applied to load anticancer drugs, such as epirubicin (EPI), by forming pH-responsive hydrazone bonds.…”

Section: Nanocellulose-based Drug Deliverymentioning

confidence: 99%

Nanocellulose‐Based Functional Materials: From Chiral Photonics to Soft Actuator and Energy Storage

Wang

et al. 2021

Adv Funct Materials

156

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Nanocellulose is currently in the limelight of extensive research from fundamental science to technological applications owing to its renewable and carbon-neutral nature, superior biocompatibility, tailorable surface chemistry, and unprecedented optical and mechanical properties. Herein, an up-to-date account of the recent advancements in nanocellulose-derived functional materials and their emerging applications in areas of chiral photonics, soft actuators, energy storage, and biomedical science is provided. The fundamental design and synthesis strategies for nanocellulose-based functional materials are discussed. Their unique properties, underlying mechanisms, and potential applications are highlighted. Finally, this review provides a brief conclusion and elucidates both the challenges and opportunities of the intriguing nanocellulose-based technologies rooted in materials and chemistry science. This review is expected to provide new insights for nanocellulose-based chiral photonics, soft robotics, advanced energy, and novel biomedical technologies, and promote the rapid development of these highly interdisciplinary fields, including nanotechnology, nanoscience, biology, physics, synthetic chemistry, materials science, and device engineering.

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“…1 Nanocellulose as multifunctional delivery vehicle. Nanocellulose could be utilized for sustained delivery of therapeutic molecules, such as anti-microbial drugs [ 40 ], as a wound healing agents [ 41 ], anti-cancer drugs [ 42 ], and various hemostatic agents [ 43 ]. Nanocellulose has also been shown to deliver nucleic acids [ 44 , 45 ], proteins [ 46 ], and certain growth promoting factors for tissue engineering [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Patil

Patel

Dutta

et al. 2022

Bioactive Materials

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Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

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Direct Surface Functionalization of Cellulose Nanocrystals with Hyperbranched Polymers through the Anionic Polymerization for pH-Responsive Intracellular Drug Delivery

Cited by 44 publications

References 53 publications

Nanocellulose: From Fundamentals to Advanced Applications

Nanocellulose: From Fundamentals to Advanced Applications

Nanocellulose‐Based Functional Materials: From Chiral Photonics to Soft Actuator and Energy Storage

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

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