Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis

Zangerle, P. F.; Groote, Donat De; López, Miguel Fraile; Meuleman, R.J.; Vrindts, Y; Fauchet, F.; Dehart, I.; Jadoul, Michel; Radoux, D.; Franchimont, P

doi:10.1016/1043-4666(92)90021-i

Cited by 101 publications

(34 citation statements)

References 43 publications

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“…Although fewer reports exist concerning this cytokine, a reduced in vitro production was found in type I diabetes, 51 even though IFN-␥ seems to play an essential role in pancreatic ␤-cell destruction of 52 and diminishes ␤-cell responsiveness to glucose. 53 Also in rheumatoid arthritis, the in vitro production of IFN-␥ is lowered, 4,54 although increased IFN-␥ levels play a significant role at the inflammatory sites of the disease. 55,56 In multiple sclerosis, IFN-␥ seems to promote the disease process.…”

Section: Production Of: Il-2 (T1) Il-2 (T2) Il-2 (T3) Ifn-␥ (T1) Ifn-mentioning

confidence: 99%

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

et al. 2000

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A pattern of aberrations in the T-cell cytokine system that is typical for autoimmune disorders has also been reported in patients with schizophrenia, namely a decreased interleukin-2 (IL-2) production and increased levels of the soluble IL-2 receptor (sIL-2R). It has also been reported that the production of interferon-␥ (IFN-␥) may be lowered. In a longitudinal design, we studied the production of both IFN-␥ and IL-2 and their correlation in patients with schizophrenia during treatment and investigated whether associations exist between cytokine production and clinical variables. The production of IFN-␥ and IL-2 was measured in equal numbers (n = 29) of patients with schizophrenia (DSM-IV) and controls who were matched for age and gender. Patients were measured 1 day after admission (T1), after 14 (T2) and 28 (T2) days of treatment. Psychopathology was assessed after these times. The production of both IFN-␥ and IL-2 was significantly lower in patients than in controls throughout the whole investigation period (T1-T3). The productions of both cytokines were significantly correlated in controls (r = 0.60, P Յ 0.001) as well as in patients with schizophrenia (mean production T1-T3: r = 0.71, P Յ 0.001). No associations between cytokine measurements and psychopathology or age-at-onset could be found. Our findings of lowered and correlated IFN-␥ and IL-2 production indicate that alterations in the cytokine system of patients with schizophrenia might resemble those in autoimmune disorders. It is suggested that these immunological abnormalities are associated with acute exacerbation, rather than with a clinical subtype of schizophrenia. Molecular Psychiatry (2000) 5, 150-158.

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Section: Production Of: Il-2 (T1) Il-2 (T2) Il-2 (T3) Ifn-␥ (T1) Ifn-mentioning

confidence: 99%

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

et al. 2000

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“…41,42 In response to pro-inflammatory cytokines, FLS produce chemokines, which further enhance inflammation, hyperplasia, and cartilage destruction. 7 To evaluate the inhibition role of DEX nanodrug on pro-inflammatory mediator expression at the protein level, we examined the effect of DEX nanodrug on the secretion of TNF-α, IL-1β, and IL-6 in TNF-α-stimulated FLS.…”

Section: Protein Expression Of Pro-inflammatory Cytokines and Mmpsmentioning

confidence: 99%

Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential

Lee¹,

Kim²,

Park³

et al. 2017

IJN

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Dexamethasone (DEX), a non-particulate glucocorticoid (GC) to inhibit anti-inflammatory response, has been widely used for the treatment of various diseases such as arthritis, cancer, asthma, chronic obstructive pulmonary disease, cerebral edema, and multiple sclerosis. However, prolonged and/or high-dose GC therapy can cause various serious adverse effects (adrenal insufficiency, hyperglycemia, Cushing’s syndrome, osteoporosis, Charcot arthropathy, etc). In this study, developed DEX-carbon nanotube (CNT) conjugates improved intracellular drug delivery via increased caveolin-dependent endocytosis and ultimately suppressed the expression of major pro-inflammatory cytokines in tumor necrosis factor-α (TNF-α)-stimulated human fibroblast-like synoviocytes (FLS) at low drug concentrations. Specifically, DEX on polyethylene-glycol (PEG)-coated CNTs induced caveolin uptake, recovered mitochondrial disruption, and inhibited reactive oxygen species production by targeting mitochondria that was released from the early endosome in TNF-α-stimulated FLS. The obtained results clearly demonstrated that DEX-PEG-coated CNTs significantly inhibited the inflammation by FLS in rheumatoid arthritis (RA) by achieving greater drug uptake and efficient intracellular drug release from the endosome, thus suggesting a mechanism of effective low-dose GC therapy to treat inflammatory diseases, including RA and osteoarthritis.

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“…Moreover, there was a trend toward a significant decreased secretion of IFN ␥ by stimulated T lymphocytes preincubated with the above antidepressants (Xia et al 1996). Recently, it has been shown that diluted whole blood stimulated with phytohemagglutinin (PHA) ϩ lipopolysaccharide (LPS) offers the most appropriate and reproducible culture condition in order to measure cytokines, such as IFN ␥ , IL-6, andIL-1 (review: De Groote et al 1992, 1993;Zangerle et al 1992). Diluted whole blood cultures reflect the in vivo immune cellular and humor interactions and may be employed to examine the effects of any substances or drugs on cytokine secretion .…”

mentioning

confidence: 99%

Negative Immunoregulatory Effects of Antidepressants Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion

Maes¹,

Song

Lin

et al. 1999

Neuropsychopharmacology

337

179

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Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis

Cited by 101 publications

References 43 publications

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential

Negative Immunoregulatory Effects of Antidepressants Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion

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