Abstract:Abstract-Direct epigenetic reprogramming is a technique that converts a differentiated adult cell into another differentiated cell-such fibroblasts to cardiomyocytes-without passage through an undifferentiated pluripotent stage. This novel technology is opening doors in biological research and regenerative medicine. Some preliminary studies about direct reprogramming started in the 1980s when differentiated adult cells could be converted into other differentiated cells by overexpressing transcription-factor ge… Show more
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