Direct relaxant effects of garlic juice on smooth and cardiac muscles

Aqel, M.; Gharaibah, Mohammad; Salhab, Abdulazim S.

doi:10.1016/0378-8741(91)90154-6

Cited by 56 publications

(39 citation statements)

References 11 publications

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“…23 It was also shown that garlic juice possesses a direct relaxing effect on the smooth muscles of the aorta, trachea, intestines and isolated rabbit hearts in vitro. 28 Garlic may provide a depressing effect on automaticity and tension development in the isolated rat heart, suggesting a b-adrenoreceptorblocking action. 17 The hypotensive effects of garlic constituents may also be explained in part by a significant biphasic diuretic and natriuretic response and by an inhibitory dose-dependent effect on the kidney Na, K-ATPase.…”

Section: Discussionmentioning

confidence: 99%

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

et al. 2009

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Numerous clinical investigations that have focused on the hypotensive effects of garlic-based preparations have led to controversial results that may be partially because of differences in the composition of the preparations and in the biological responses they induce. It is possible that garlic powder tablets with a prolonged mode of action could induce more potent biological effects. In this double-blind, placebo-controlled trial with an active control arm, the hypotensive action of time-released garlic powder tablets (Allicor) was compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension. After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n¼30) or to placebo (n¼20) daily for 8 weeks. In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n¼18) or 900 mg Kwai daily (n¼16). Allicor treatment (600 mg daily) resulted in a reduction of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively. Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit. Treatment with Kwai resulted in the same decrease in systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as that seen with Allicor, but no decrease in diastolic blood pressure was observed with Kwai. Different effects of Allicor and Kwai on diastolic blood pressure may be because of the prolonged action of Allicor, which allows better bioavailability of the vasoactive constituents of garlic powder. The results of this study show that time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements.

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Section: Discussionmentioning

confidence: 99%

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

et al. 2009

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“…So, CSAE may produce vasorelaxation via α 1 -adrenoreceptors non competitive antagonisms. Previous studies demonstrated similar vasorelaxant effect [2,3,15,16] . Endothelium plays a crucial role in the smooth muscle vasorelaxation [12] , several studies confirmed the involvement of this vascular part in the pathophysiology of hypertension [14] .…”

Section: Discussionmentioning

confidence: 58%

Cardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: In vitro Vasorelaxant Effect

Zeggwagh¹,

Michel²,

Eddouks³

2007

American J. of Pharmacology and Toxicology

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Abstract:The aim of this study was to investigate the in vitro vasorelaxanteffect of Capparis spinosa Aqueous Extract (CSAE) at a dose of 10 mg mL −1 . Aortic rings isolated from normal wistar rats were used. The addition of CSAE during the plateau phase of contraction, induced by noradrenaline and KCl, produced a rapid relaxation. Incubation of aortic ring with CSAE during 30 min shifted the noradrenaline induced dose response curve (p<0.001) and the maximum response (p<0.001) was attenuated indicating that antagonist effect of the α1 adrenoreceptors was non-competitive. However, endothelium remove significantly reduced the vasorelaxant effect of CSAE (p<0.01). Furthermore, nitric oxide inhibition reduced the vasorelaxant effect of CSAE. However, cyclo-oxygenase inhibition did not affect the vasorelaxant effect of CSAE (p<0.05). Inhibition of L-type voltage dependent Ca2+ channels did not reduce the observed CSAE vasorelaxant effect (p<0.05). We conclude that CSAE at a dose of 10 mg mL −1 possess in vitro vasorelaxant effect which may by mediated via an α1 adrenoreceptors antagonism and/or modulation of nitric oxide synthesis.

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“…Garlic is also a potent antioxidant (16), it has an anticoagulant effect (17,18), and decreases blood pressure (14,19,20). Numerous studies have demonstrated the vasodilatory effects of garlic (21,22), but the mechanism of action remains unclear. While some people propose a mechanism of action in which an activation of NO synthase is implicated (2), others favor a direct effect on vascular smooth muscle 5 mM) into smooth muscle cells of control aortas and RG 20-100-treated aortas (100 m g/ml, 300 mg/ml, or 500 mg/ ml).…”

Section: Discussionmentioning

confidence: 99%

An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity

et al. 2004

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Abstract. The aim of this study was to investigate the effect of different novel extracts and fractions obtained from Allium sativum (garlic) on in vitro vessel contraction in order to deepen our knowledge of their mechanism of action on vascular reactivity. The contraction induced by noradrenaline (NE, 10 -6 or 10 -5 M) or KCl (80 mM) was relaxed with all the extracts and fractions studied, but this effect was higher with RG 20-100 (raw garlic fraction) and FG 20-100 (frozen garlic fraction). To increase our understanding of the mechanisms of action of RG 200-100 and FG 200-100, we found their inhibitory actions were retained in the absence of endothelium, whereas inhibition of the entry of extracellular calcium and mobilization of intracellular calcium may play an instrumental role.

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Direct relaxant effects of garlic juice on smooth and cardiac muscles

Cited by 56 publications

References 11 publications

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

Cardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: In vitro Vasorelaxant Effect

An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity

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